Rachel Barcelo Email and Phone Number

Upstream Cell Culture Scientist and Manager to a team of scientists and engineers, driving pilot-scale operations and programs to support a robust internal pipeline and external manufacturing partnerships.

Construct mammalian cell lines expressing monoclonal antibodies for manufacturing biologic medicines. Experience with DNA vector construction, multiple transfection techniques, image-based single cell cloning, and clone assessment in an industry-leading cell line development platform. Evaluating novel technologies to shorten timelines and optimize platform processes.

Experience leading cell culture bioreactor processes in 50L to 1000L stainless and single-use vessels. Collaborated across departments and sites to ensure facility comparability, including conducting mass transfer and mixing studies at 15000L scales in GMP manufacturing facilities in the US and Denmark. External academic collaborations focusing on redesigning pilot and manufacturing spargers to optimize gas flow, mass transfer, and reduce shear damage to cells; surfactant studies to understand shear stress and cell protection; and foam investigations to analyze foam build-up, stability, and assess mitigation techniques. Assisted with the development, testing, and implementation of electronic lab notebook and data capture software.