Rachel Tam Email & Phone Number

Lawrence Township, Nj, Us

- Biomarker Lead of multiple BMS IO-based clinical trials, including late stage molecules (Nivolumab, Ipilimumab, Relatlimab, IDO1 inhibitor and combination)- Biomarker lead of Repotrectinib (Augtyro) pediatric/young adults ROS1+/NTRK+ solid tumors CARE study- Provides biomarker leadership in MSI-H & MSS Colorectal, Gastric and Pediatric cancer disease strategies - Responsible for developing the biomarker strategy and utilizing emerging diagnostics for the oncology pipeline across all stages of clinical development including regulatory submission - As a pediatric biomarker lead in Pediatric Center of Excellence (PCoE), I am responsible for leading pediatric biomarker strategies for > 20 different solid tumor/ Heme assets in the pipeline across different TRCs/ TM, delivering preclinical biomarker packages to aid iPSP/PIP/ waivers submissions to FDA/EMA. -Responsible for biomarker elements in clinical protocols, biomarker analysis plans, regulatory submissions, investigator meetings, advisory boards and publications- Lead forward and reverse translation research to gain further insights into potential mechanisms of response and resistance to cancer immunotherapy

Lawrence Township, Nj, Us

South San Francisco, California, Us

• Biomarker team member in cancer immunology franchise focusing on multiple GI cancer and T cell bispecifics clinical trials• Co-biomarker lead for biomarker discovery, phase 1 clinical trials and diagnostic strategies in Pediatric cancer• Facilitate and develop cancer biomarker exploratory strategies and collaborations on Pediatric and adult cancers with academic institutions and hospitals • Develop outsourcing strategy and communication with CROs and BOMs for sample processing, assay implementation and validation• NGS technology evaluation on FFPE and cell-free DNA samples using Ion Torrent PGM/S5XL, Ion Chef and automated library preparation technology on Ampliseq cancer mutation hotspot panel and molecular-tagging NGS technology• NGS data analysis utilizing Integrative Genomics Viewer (IGV), Partek and other 'Omics' softwares• Digital gene expression analysis by Nanostring technologies• Designed, validated and executed the in-house 6-gene, 11-gene,13-gene and CRC-focused high-throughput mutation detection and copy number variation panels using Fluidigm microfluidics technology, supporting the vigorous pipeline from gRED• Supported the development of high-throughput Fluidigm methylation panel• Analyzed and QC clinical FFPE, fresh frozen, TMA, exosomal RNA and cfDNA samples on mutation panels to support Genentech's (gRED) vigorous pipelines• Digital PCR technology evaluation (Life technologies and Bio Rad ddPCR systems) for mutation detection/copy number analysis• HER2 droplet ddPCR copy number analysis on cfDNA clinical samples • Developed and validated the in-house gene expression panels (HPV, Epigenetics...etc) to support multiple clinical trials and research groups• Genome-wide Epigenetics (ChIP-PCR) studies, examining DNA binding proteins on cell lines • Presented scientific data both externally (AACR) and internally• Trained and mentored RAs on running in-house qPCR, ddPCR and NGS technologies and presentations

South San Francisco, California, Us

• Macro-dissected tumour FFPE tissues from slides and perform de-paraffinazation• Isolated DNA and RNA from FFPE tissue sections• Documented and maintained the clinical/vendor procured samples database for the tissue core group.• Validated and ran the Angiogenesis gene expression panel for VEGF research group. Clinical, vendor procured and collaboration FFPE/fresh frozen samples were analyzed• Analyzed and QC gene expression data• Trained colleagues to perform de-paraffinazation, nucleic acid isolations and Fluidigm Biomark chip runs• Ordered lab supplies• Assisted with freezers reorganization

San Francisco, California, Us

Bryan, Tx, Us

Sydney, New South Wales (Nsw), Au

Managed supervisor and students Accounting Research reagents and lab consumables ordering Trained users of tissue culture facilities, gel-doc systems, coulter counter technology and western blotting techniquesAssisted students with technical difficulties with their research projects Arranged meetings with other lab members and sales representatives

Mini-Mba Biopharma Innovation

Phd, Pharmacology

Bsc (Hons), Pharmacology

Bsc, Physiology And Pharmacology