Rashade A. H. Haynes Ii Email & Phone Number

New Brunswick, New Jersey, United States

As a dedicated and innovative Scientific Associate Director in Immunonology and Investigative toxicology, I lead cutting-edge research teams and development initiatives within the Nonclinical Science and Veterinary Sciences organization within R&D. With a strong focus on evaluating the immunotoxicological profiles of novel therapeutics, I leverage my extensive expertise in immunology, toxicology, and preclinical studies to drive impactful scientific discoveries. My role involves designing and overseeing comprehensive immunotoxicology studies, interpreting complex data, and ensuring regulatory compliance to support the advancement of safe and effective treatments. I collaborate closely with cross-functional teams, including pharmacology, pathology, and regulatory affairs, to integrate immunotoxicology insights into the broader drug development process. Key responsibilities include:- Leading the design and execution of immunotoxicology studies to assess the safety of new drug candidates.- Analyzing and interpreting immunotoxicological data to inform decision-making and regulatory submissions.- Collaborating with multidisciplinary teams to integrate immunotoxicology findings into preclinical development strategies.- Staying abreast of the latest scientific advancements and regulatory guidelines in immunotoxicology and preclinical science.- Mentoring and guiding junior scientists to foster a culture of scientific excellence and innovation. With a passion for advancing scientific knowledge and improving patient outcomes, I am committed to contributing to the development of groundbreaking therapies that address unmet medical needs.

New Brunswick, New Jersey, United States

New Brunswick, New Jersey, United States

Immuno and Molecular toxicology

New Jersey, United States

New Brunswick, New Jersey

New Brunswick, New Jersey, United States

Cranbury, Nj

Bioassay Development• Developed and qualified potency assays as well as functional characterization assays for adalimumab and bevacizumab biosimilars• Completed FFP and Qualification reports for CDC, FcRN (SPR Biacore T200) methods• Lead project as SME and developed novel whole blood cytotoxicity assay to assess similarity of adalimumab biosimilar molecule in physiological conditions• Lead project as SME and completed method development report describing an optimized assay for stimulating primary TNF expressing monocytes for targets in ADCC • Lead project as SME and completed FFP for Receptor density assay used to qualify cell lines for RD and QC assays• Lead project as SME to develop FFP for bevacizumab dimerization assay to show similarity between our molecule and innovator• Provide support thorough bioassay development and testing for investigational studies aimed at establishing structure-function correlation of new molecules in our pipeline• Provide support through bioassay testing for release, stability, process development and formulation development activities• Collaborate and work with QC and Process Development on scientific issues• Ability to troubleshoot and maintain the equipment utilized within the department• Maintain equipment logbooks (calibration and validation) and electronic notebook entries

New Brunswick, New Jersey

Research:I was responsible for driving a project which explored the role of a novel BTB-zinc finger transcription factor "X" in two unreported subsets T cells. These subsets rapidly produced effector cytokines hours following TCR mediated activation. In addition, I was able to show a potential mechanism through ChIP analysis that would explain how our novel BTB-ZF modulates cytokine expression. The results from this project will be published in a high quality immunology journal.Mentoring and Teaching Experience:During my post doctoral fellowship I have been given the privilege to mentor many students (medical, graduate and undergraduate). I have taught students how to set up proper experiments using positive and negative controls and more difficult techniques i.e.FACS (10+ color), RT-PCR and ChIP.

Greater New York City Area

Research:I created a BTB-zinc finger transcription factor "X" GFP reporter mouse using a BAC and recombineering technology. I identified 2 uniques T cell subsets using the newly created GFP reporter mouse. Using a Scurfy mouse model I was able to examine the role of the newly identified T cells in autoimmunity. Additionally through microarray analysis I determined that the new T cell subsets were indeed genetically unique compared to non-expressing T cells.

Columbus, Ohio Area

• Published 3 first author manuscripts in major academic journals including Blood, Journal of Virology and Viral Immunology• Developed a model of oral transmission for infection with the retrovirus HTLV-1 in the rabbit model of infection• Characterized the role of HTLV-1 infected lymphocytes in lymphoid organs and gut associated lymphoid tissue• Measured p19 as a biomarker of HTLV-1 infection and correlated it to proviral load by RT-PCR• Generated immortalized primary rabbit fibroblasts cell lines (SV40)• Generated HTLV-1 infected rabbit lymphocyte cell lines from co-cultures with HTLV-1 infected immortalized cell lines• Optimized cell growth parameters and cytotoxicity to cyclosporine A• Biomarker assay optimization/validation: measured p19 from tissue resident lymphocytes (biomarker for proviral load)

Columbus, Ohio Area

Graduate Research Associate in the Department of veterinary BioscienceArea of focus: Cellular and Molecular Immunology and RetrovirologyLab: Dr. Michael D. Lairmore DVM, PhD ACVP. Dep. Chair

Phd., Cellular And Molecular Immunology And Retrovirology

Activities and Societies: Black Graduate and Professional Student Caucus

B.S., Animal Science