Investigating mechanisms regulating meiotic crossover frequency in plant meiosis.

Worked in the team of Chromosome dynamics and recombination headed by Dr. Valerie Borde- Identified a new regulatory step that controls gene conversion track lentgh during meiotic recombination.http://dx.doi.org/10.7554/eLife.21900

Postdoc fellow in the recombination and meiosis team headed by Dr. Bernard de Massy focusing on investigating DNA double-strand break (DSB) formation during meiotic recombination in mouse Key achievements: • Contributed to the identification of putative mouse DSB genes by novel bioinformatics assays.• Developed screening to identify potential genes for meiotic DSB formation by gene expression analysis and protein-protein interaction assays• Performed functional analysis… Show more Postdoc fellow in the recombination and meiosis team headed by Dr. Bernard de Massy focusing on investigating DNA double-strand break (DSB) formation during meiotic recombination in mouse Key achievements: • Contributed to the identification of putative mouse DSB genes by novel bioinformatics assays.• Developed screening to identify potential genes for meiotic DSB formation by gene expression analysis and protein-protein interaction assays• Performed functional analysis of DSB genes in homologous recombination through characterization of mouse knockout using chromosome spreading, immunoflorescence, PCR, immunoprecipitation assays, western blotting, antibody purification and histology techniques• Established collaborations. Contributed to lab management and prepared fellowship grants, article and review manuscripts. Supervised and trained master students Show less

Title: Insertion of mitochondrial DNA (mtDNA) in nuclear genome Key achievements: • Identified factors affecting insertion of mtDNA in nuclear genome in fission yeast by using yeast transformation and PCR based assays• Developed approach to investigate mtDNA insertion in several tumor cell lines and solid tumor samples