Rajesh Kishore Kumar Sanku, Ph.D. Email & Phone Number
@gilead.com
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Rajesh Kishore Kumar Sanku, Ph.D. is listed as Senior Scientist 2 at Exelixis at Exelixis, a company with 51 employees, based in San Francisco Bay Area, United States, United States. AeroLeads shows a work email signal at gilead.com and a matched LinkedIn profile for Rajesh Kishore Kumar Sanku, Ph.D..
Rajesh Kishore Kumar Sanku, Ph.D. previously worked as Senior Scientist 2 at Exelixis and Reviewer of Bioorganic & Medicinal Chemistry Letters at Elsevier Publishing Services. Rajesh Kishore Kumar Sanku, Ph.D. holds Post Doc from University Of Pennsylvania School Of Medicine.
Email format at Exelixis
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About Rajesh Kishore Kumar Sanku, Ph.D.
A passionate and highly motivated scientist with a strong background in protein biochemistry, and molecular biology. I have over 6 years of experience in biochemistry, PK-PD (Pharmacokinetic/Pharmacodynamic) profiling of drugs and modern bioanalytical research.• Developing bioanalytical methods for quantitation and metabolism/biotransformation assessment of small molecule drugs, antibodies, fusion proteins, antibody drug conjugates and Probodies•PK Exposure using ELISA/LBA and Biologics quantitation using MSD. •Translational Biomarker studies on clinical samples.•Proteomics for development of qualitative/quantitative assays for proteins/peptides and post-translational modifications.•Metabolomics on high-resolution Orbitraps and Triple Quadrupole MS.•LC-MS sample preparation from biological matrices (cell, tissue, serum, plasma).Technical skills: Protein expression and purification, stable isotope labelling with amino acids in cell culture(SILAC), immunoprecipitation, parallel reaction monitoring(PRM), selected reaction monitoring(SRM), multiple reaction monitoring(MRM), solid phase extraction(SPE), liquid-liquid extraction(LLE), lipid extraction, BCA assay, Immunoassays, gel-electrophoresis, cell cultures(2D, 3D), neurotoxicity, western blotting, microsomal stability, plasma protein binding, permeability assays, metabolite identification, solubility, lipophilicity and enzyme kinetic studies. UPLC, HPLC, 2D-nano-UPLC(Dionex), Thermo Q Exactive HF Hybrid Quadrupole-Orbitrap, TSQ triple quadrupole, Waters TQ MS. Mass spectrometer maintenance including removing/cleaning/inserting of parts like ion transfertube/tube lens/skimmer/pump/Q0 and regular tuning and calibration of the instruments.Interpreting mass spectrometry data and statistical analysis using tools Xcalibur, Tracefinder, Mass Hunter, MassLynx, TargetLynx, Skyline, proteome discoverer, GraphPad Prism.►Connect with me on LinkedIn or email me directly-rajeshkishorekumar@gmail.com.
Listed skills include Research, Hplc, Lc Ms, Confocal Microscopy, and 41 others.
Rajesh Kishore Kumar Sanku, Ph.D.'s current company
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Rajesh Kishore Kumar Sanku, Ph.D. work experience
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Reviewer Of Bioorganic & Medicinal Chemistry Letters
Current
Drug Metabolism And Pharmacokinetics (Dmpk) Scientist
o Developed and validated bioanalytical LC-MS/MS methods for the quantitative and qualitative analysis of peptides, proteins, antibodies, and antibody-drug conjugates (ADCs). Designed PK/PD and ADA assays, and conducted sample analysis, including non-compartmental analysis (NCA) of LC-MS and MSD data.o Collaborated with Contract Research Organizations.
Research Scientist 2
o Worked for various clients in the discovery bioanalysis team for method development, implementation, and validation of various bioanalytical assays using PK/PD ligand binding assays/ELISA, MSD of macromolecules.o Transferred the validated method to research associates for the high throughput screening.o Developed bioanalytical LC-MS/MS methods for small.
Scientist
o Developed bioanalytical LC-MS/MS methods for the quantitative and qualitative analysis of peptides, proteins, antibodies and antibody-drug conjugates (ADCs) in biological sampleso Sample preparation and analysis of biotherapeutics from PK samples including immunoprecipitation/affinity capture using bead-based and/or automated platformso Quantitative.
Postdoctoral Researcher
- Worked on a 2 Million dollars project which aims at the Biomarker identification of early cancer detection.
- Performed assay development for sample preparation protocols from biological matrices for mass spectrometry analysis; establish SOPs.
- Development and validation of quantitative methods for large and small molecule analysis using nano-LC and mass spectrometry.
- Implementation of various mass spectrometry methods, for proteomics, lipidomics and metabolomics.
- Experience with protein post-translational modification analyses.
- Determination of small molecule metabolites (e.g. steroids) using chemical derivatization from biological matrices related to cancers.
Phd Researcher
- My research was focused on PK/PD screening of Anti-cancer and CNS drugs.As a doctoral candidate I:
- Worked under two advisors (biochemist and behavioral pharmacologist) on a collaborate dissertation project.
- Developed protocols, designed experiments, collected and analyzed data which resulted in presentations at 8 national conferences, 2 manuscripts and 1 book chapter.
- Maintained collaborative relationships with 3 research groups to support research goals.
- Developed various LC/MS/MS techniques and executed experiments, such as microsomal stability, blood brain barrier permeability, plasma protein binding solubility, lipophilicity, toxicity assays, to screen novel drugs.
- Designed and carried a metabolomics study, analzed and integrated protein expression and cell metabolosim data to identify to find a potential biological pathways leading to discovery of novel biomarkers during a.
Pharmacovigilance Scientist
- Worked on ARGUS, safety database management software used for reporting to various regulatory authorities like F.D.A, Medicines and Healthcare products Regulatory Agency.
Summer Intern
- Worked with Bioequivalence testing department.
- Assisted with coordination, preparation and review of clinical trial applications.
- Responsible for filing applications, follow ups and obtaining permissions/licences for drug approval.
Colleagues at Exelixis
Other employees you can reach at exelixis.com. View company contacts for 51 employees →
Ss Mohammed
Colleague at ExelixisSacramento, California, United States, United States
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Mary Foody
Colleague at ExelixisHialeah, Florida, United States, United States
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Ivan Guzman
Colleague at ExelixisSan Francisco Bay Area, United States
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Saik Kia Goh, Ph.D.
Colleague at ExelixisSan Francisco Bay Area, United States, United States
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Tim Hawkins
Colleague at ExelixisSouth San Francisco, California, United States, United States
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Sampath Sundararajan
Colleague at ExelixisAtlanta Metropolitan Area, United States, United States
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Jennifer Allison, Ms
Colleague at ExelixisGreater Philadelphia, United States, United States
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Iesha Mandolph
Colleague at ExelixisOakland, California, United States, United States
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Ali Ozkabak
Colleague at ExelixisPleasanton, California, United States, United States
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PB
Paula Belekewicz
Colleague at ExelixisWesterly, Rhode Island, United States, United States
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Rajesh Kishore Kumar Sanku, Ph.D. education
Post Doc
Doctor Of Philosophy (Ph.D.), Pharmaceutical Sciences
Bachelor Of Pharmacy (B.Pharm.)
Model-Informed Drug Development
Frequently asked questions about Rajesh Kishore Kumar Sanku, Ph.D.
Quick answers generated from the profile data available on this page.
What company does Rajesh Kishore Kumar Sanku, Ph.D. work for?
Rajesh Kishore Kumar Sanku, Ph.D. works for Exelixis.
What is Rajesh Kishore Kumar Sanku, Ph.D.'s role at Exelixis?
Rajesh Kishore Kumar Sanku, Ph.D. is listed as Senior Scientist 2 at Exelixis at Exelixis.
What is Rajesh Kishore Kumar Sanku, Ph.D.'s email address?
AeroLeads has found 1 work email signal at @gilead.com for Rajesh Kishore Kumar Sanku, Ph.D. at Exelixis.
Where is Rajesh Kishore Kumar Sanku, Ph.D. based?
Rajesh Kishore Kumar Sanku, Ph.D. is based in San Francisco Bay Area, United States, United States while working with Exelixis.
What companies has Rajesh Kishore Kumar Sanku, Ph.D. worked for?
Rajesh Kishore Kumar Sanku, Ph.D. has worked for Exelixis, Elsevier Publishing Services, Gilead Sciences, Charles River Laboratories, and Bristol-Myers Squibb.
Who are Rajesh Kishore Kumar Sanku, Ph.D.'s colleagues at Exelixis?
Rajesh Kishore Kumar Sanku, Ph.D.'s colleagues at Exelixis include Ss Mohammed, Mary Foody, Ivan Guzman, Saik Kia Goh, Ph.D., and Tim Hawkins.
How can I contact Rajesh Kishore Kumar Sanku, Ph.D.?
You can use AeroLeads to view verified contact signals for Rajesh Kishore Kumar Sanku, Ph.D. at Exelixis, including work email, phone, and LinkedIn data when available.
What schools did Rajesh Kishore Kumar Sanku, Ph.D. attend?
Rajesh Kishore Kumar Sanku, Ph.D. holds Post Doc from University Of Pennsylvania School Of Medicine.
What skills is Rajesh Kishore Kumar Sanku, Ph.D. known for?
Rajesh Kishore Kumar Sanku, Ph.D. is listed with skills including Research, Hplc, Lc Ms, Confocal Microscopy, Behavioral Pharmacology, Microtome, Immunohistochemistry, and Microscopy.
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