Rakesh Thorat, Phd Email & Phone Number

Pune, Maharashtra, India

Pune

Involved in literature survey, establishing, optimizing the synthetic routes for scale up.Establishing short scalable and economic synthetic routes for API's.Working on flow chemistry to simplify the scale up related issues with critical reactions.Involved in alternate vendor development including but not limited to managing evaluation, analysis, user trials, demonstrations etc. for various ongoing projects.Involved in documentation for submission to regulatory agencies. Responding to deficiencies in timely manner.

Montreal, Quebec, Canada

Worked on different projects involving synthesis of challenging molecules for weekly submissions.Designing and docking libraries and then sorting out the molecules based on the properties for synthesis.

Lubbock, Texas

Established a short, quick and versatile methodology to synthesize macrolides with significant biological activity. Strategy focuses on rapid synthesis of a common intermediate with minimum protecting group manipulations, catalytic installation of stereocenters.Worked on synthesis of Hasubanan (HB) alkaloids, believed to have potential binding activities towards opioid receptors similar to morphine and its congeners. A rapid synthesis of tetracyclic core of HB alkaloids is being explored.Outstanding planning and attention to detail resulted in setting up current laboratory in three weeks to provide safe working environment withholding all the safety standards.Management Responsibilities - Maintaining various instruments worth over $125,000 for daily operations as well as troubleshooting during operational issues that includes - High Performance Liquid Chromatography (HPLC) instrument Thin Layer Chromatography-Mass Spectroscopy (TLC-MS), CEM Microwave Reactor Mettler Toledo ReactIR Thermo Scientific FT-IR instrument LC Technology SPS system- Managing and updating Laboratory Safety Plan for successful execution of the safety protocols.Training and Mentoring Responsibilities - - Trained 4 graduate and 4 undergraduate students in the lab for safe research practices.- Provide training to all the students for safe and appropriate use of laboratory instruments. - Helping students in data analysis and in the event of malfunction of instruments.- Mentored 2 undergraduate students for their research projects (planning, reaction set-up, data analysis). - Mentored 2 visiting (K-12) students for summer research program.

Newfoundland And Labrador, Canada

Developed a strategy for the synthesis of quaternary stereocenters using metal catalyzed cross-coupling reactions of alkylidene morpholinones. This strategy was employed for the synthesis of various aldehydes/carboxylic acids with quaternary stereocenters.A unique strategy for the synthesis of indolizidine and quinolizidine alkaloids was developed using 1,3-dipolar cycloaddition of nitrones and was implemented in total synthesis of (+)-epitashiromine and formal syntheses of (+)-epilupinine and (+)-tashiromine.Expertise in maintaining experimental records, analytical data (NMR, LC-MS, IR, HRMS), structure elucidation using NMR techniquesIn charge of maintaining and updating chemical inventory, laboratory safety protocolsTrained number of undergraduate and honors students giving them maximum exposure of research laboratory environment. Mentoring them for learning basic research techniques, safety protocols, handling of hazardous chemicals, time management.

Pune

Worked on various synthetic chemistry projects, main task was to establish scalable synthetic routes to enantiomerically pure target compounds as per clients requests.Successfully completed a 12 step synthesis of diastereomerically pure target (multi gram delivery) involving establishing the synthetic route and complete optimization of the sequence for scale up. The established sequence provided the analogues for two more projects.Large scale (up to a kilogram) reactions in a conventional laboratory set up such as acid-amine coupling, catalytic hydrogenation, kinetic resolution, oxidations and protecting group manipulations.Comfortably executed full time synthetic bench work while maintaining complete records including experimental procedures, analytical data (NMR, HPLC, LC-MS), weekly client reports and updates on synthetic strategy.Tasked with inventory management for all the chemicals and maintaining daily supplies for the entire laboratory (group of 16 chemists).

Doctor Of Philosophy (Ph.D.), Chemistry

Activities and Societies: GSU Representative (2011-12) - Indian Youth Association, Memorial University. Chemistry Steward (2012-2014).

Master Of Science - Ms, Organic Chemistry

Bachelor Of Science - Bs, Chemistry