Ralf Hoffmann Email & Phone Number

Eindhoven, Nb, Nl

• Group leader 'Diagnostic and Prognostic Biomarker Research' in oncology related projects • Implementation of a high-throughput proteomic profiling approaches based on multi-dimensional LC coupled to MALDI-TOF/TOF and hybrid triple Quadrupole mass spec for biomarker discovery and validation in human body fluids and human tissue samples• Identification of diagnostic, prognostic, surrogate and predictive biomarker discovery and implementation for the early diagnosis, molecular imaging… Show more • Group leader 'Diagnostic and Prognostic Biomarker Research' in oncology related projects • Implementation of a high-throughput proteomic profiling approaches based on multi-dimensional LC coupled to MALDI-TOF/TOF and hybrid triple Quadrupole mass spec for biomarker discovery and validation in human body fluids and human tissue samples• Identification of diagnostic, prognostic, surrogate and predictive biomarker discovery and implementation for the early diagnosis, molecular imaging and therapy of tumour diseases• Initiating and leading academic/clinical collaborations (Netherlands, UK, Germany)• Development of business scenarios and biomarker valorization strategies• Coordination of the Philips Research PhD studentship program with UK Research Councils (in particular BBSRC, and MRC) • Functional analysis of target proteins for prostate cancer diagnosis and therapy. Show less

• Team Leader ‘Target/Biomarker Discovery’ • Introduction of approaches to analyze gene expression profiles (Overlap, Monte-Carlo Simulations, Clustering, ´Marker-Genes´, Genetic Networks)• Molecular profiling of CNS-active pharmaceutical drugs by gene expression studies Setting up of an innovative assay to perform a simple prediction by pattern recognition about the therapeutic action and potential adverse effects of novel drug candidates, thereby helping the pharmaceutical industry… Show more • Team Leader ‘Target/Biomarker Discovery’ • Introduction of approaches to analyze gene expression profiles (Overlap, Monte-Carlo Simulations, Clustering, ´Marker-Genes´, Genetic Networks)• Molecular profiling of CNS-active pharmaceutical drugs by gene expression studies Setting up of an innovative assay to perform a simple prediction by pattern recognition about the therapeutic action and potential adverse effects of novel drug candidates, thereby helping the pharmaceutical industry to decrease development costs• Classification of CNS compounds according to their chemical structure, and pharmacological profile in vivo• Classification of CNS compounds according to their induced side-effects in man• Creating a gene expression database to identify genetic interactions and networks, leading to a useful model of this complex system• Responsibility for the organisation and the analysis of customer-projects Show less

• Respiratory disease research• Responsibility for the design and Management of a project to unravel the cellular function and the signaling of cAMP-selective phosphodiesterases (PDEs)• Cloning, heterologous expression (prokaryotic, eukaryotic cells) and ´genetic engineering´ of PDE-mutants for the use in a ´high-throughput drug screening´ to identify novel lead-compounds• Establishment of a HTS-assays to screen inhibitory molecules for phosphodiesterases

• Postdoc Position at the University of Konstanz with a scholarship of the European Community• Project grant to establish protein expression in eukaryotic cells • Construction of protein expressions vectors for the use in Yeast Saccharomyces cerevisiae

• Postdoc Position at the University of Ulm in the department\ ´Allergy/Dermatology´ • Development of RNA antisense-technologies for the treatment of malignant Lymphomas

Phd, Biology

• Ph.D. at the University of Konstanz, Germany in the department of Biochemistry/Signal transduction • Management of a project.

Msc, Biology

• Studies of Biology with focus on: • Protein-Biochemistry and Enzymology • Physiology • Biophysics • Pharmacology