Ralf Hoffmann Email & Phone Number

Eindhoven, NB, NL

• Group leader 'Diagnostic and Prognostic Biomarker Research' in oncology related projects
• Implementation of a high-throughput proteomic profiling approaches based on multi-dimensional LC coupled to MALDI-TOF/TOF and hybrid triple Quadrupole mass spec for biomarker discovery and validation in human body.
• Identification of diagnostic, prognostic, surrogate and predictive biomarker discovery and implementation for the early diagnosis, molecular imaging… Show more
• Identification of diagnostic, prognostic, surrogate and predictive biomarker discovery and implementation for the early diagnosis, molecular imaging and therapy of tumour diseases
• Initiating and leading academic/clinical collaborations (Netherlands, UK, Germany)
• Development of business scenarios and biomarker valorization strategies

• Team Leader ‘Target/Biomarker Discovery’
• Introduction of approaches to analyze gene expression profiles (Overlap, Monte-Carlo Simulations, Clustering, ´Marker-Genes´, Genetic Networks)
• Molecular profiling of CNS-active pharmaceutical drugs by gene expression studies Setting up of an innovative assay to perform a simple prediction by pattern recognition about the therapeutic action and potential.
• Molecular profiling of CNS-active pharmaceutical drugs by gene expression studies Setting up of an innovative assay to perform a simple prediction by pattern recognition about the therapeutic action and potential.
• Classification of CNS compounds according to their chemical structure, and pharmacological profile in vivo
• Classification of CNS compounds according to their induced side-effects in man

• Respiratory disease research
• Responsibility for the design and Management of a project to unravel the cellular function and the signaling of cAMP-selective phosphodiesterases (PDEs)
• Cloning, heterologous expression (prokaryotic, eukaryotic cells) and ´genetic engineering´ of PDE-mutants for the use in a ´high-throughput drug screening´ to identify novel lead-compounds
• Establishment of a HTS-assays to screen inhibitory molecules for phosphodiesterases

• Postdoc Position at the University of Konstanz with a scholarship of the European Community
• Project grant to establish protein expression in eukaryotic cells
• Construction of protein expressions vectors for the use in Yeast Saccharomyces cerevisiae

• Postdoc Position at the University of Ulm in the department\ ´Allergy/Dermatology´
• Development of RNA antisense-technologies for the treatment of malignant Lymphomas

Phd, Biology

• Ph.D. at the University of Konstanz, Germany in the department of Biochemistry/Signal transduction • Management of a project for the.

Msc, Biology

• Studies of Biology with focus on: • Protein-Biochemistry and Enzymology • Physiology • Biophysics • Pharmacology