Ralph (Adam) Smith, Phd, Mba Email and Phone Number
Driven leader of translational imaging science dedicated to achieving productive collaborations that result in exceptional outcomes for patients. • Lead company-wide translational strategy for molecular imaging portfolio in all therapeutic areas • Responsible for clinical imaging (all modalities) for company lung fibrosis and early neuroscience portfolios – experience in clinical drug development, protocol writing/development, and regulatory submissions• Proven record of translating scientific discovery to clinical application – successful regulatory filings in US, Canada, and EU• Experience in integrating translational science / translational medicine approaches in drug development• Integrate and lead cross-functional scientific and research teams consisting of physicians, biologists, chemists, engineers, manufacturing, operational and regulatory components• Work recognized with 2017 Ondetti & Cushman Award (highest R&D award at Bristol-Myers Squibb) and 2014 Research Leveraging Technology Innovation Award• Adept at stakeholder and collaboration management linking industry, academia, andcommercial partners
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Scientific Senior Director - Imaging (Clinical Neuroscience, Lung Fibrosis, And Molecular Imaging)Bristol Myers Squibb Nov 2023 - PresentPrinceton, NjDrive company-wide clinical imaging strategy and execution for Neuroscience and lung fibrosis clinical trials to enable decision-making for portfolio assets. Responsibilities include oversight of end-to-end novel tracer development, imaging integration with translational sciences and asset development plans in both discovery and early clinical phases, implementation and delivery of imaging endpoints in clinical trials, and establishment/maintenance of relationships with imaging core labs, CROs and KOLs. Integrate and coordinate contributions from multiple functional areas including biomarkers, discovery biology, chemistry, clinical, regulatory, and upper management to enable imaging applications across the development continuum. -
Scientific Director - Imaging (Molecular Imaging, Clinical Lung Fibrosis And Early Neuro Lead)Bristol-Myers Squibb Mar 2018 - Oct 2023Princeton, Nj
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Associate Director - Molecular Imaging LeadBristol-Myers Squibb Oct 2015 - Mar 2018Princeton, NjLead company-wide molecular imaging portfolio for all therapeutic areas including preclinical, early development, and translation of novel imaging agents to the clinic. Responsible for designing and implementing molecular imaging strategy and novel tracer development to drive both preclinical and clinical asset development. Integrate and coordinate contributions from multiple functional areas to enable imaging tracer implementation to address key scientific questions from discovery through human trials. Received 2017 Ondetti & Cushman Award (highest scientific award at BMS) for implementation of novel imaging technologies to immuno-oncology platform.
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Associate Director - Oncology Molecular Imaging LeadBristol-Myers Squibb Aug 2014 - Oct 2015Princeton, NjLead molecular imaging for oncology and immuno-oncology portfolio including preclinical, early discovery, and late phase imaging. Responsible for designing and implementing molecular imaging strategy and novel tracer development to drive both preclinical and clinical asset development. Integrate and coordinate contributions from multiple functional areas to guide imaging tracer development from preclinical assessment to utilization in human trials.
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Senior Research Investigator Ii, Dmcp - BioimagingBristol-Myers Squibb, Princeton, New Jersey Jan 2012 - Aug 2014Princeton, NjProject leader for preclinical PET and optical imaging serving multiple therapeutic areas. Responsible for design and implementation of imaging studies to impact preclinical and clinical development as well as clinical trial design. Interface with working groups and stakeholders to impact biomarker strategy for developing and marketed assets. Received 2014 Research Leveraging Technology Innovation award for implementation of novel imaging technologies to immuno-oncology platform.
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Research Fellow In RadiologyVanderbilt University Medical Center Nov 2009 - Nov 2011Manage collaborative preclinical imaging efforts for research group in an imaging core facility. Utilize imaging methodologies including nuclear ([18F]-FDG, [18F]-FLT, novel probes), CT, MRI, ultrasound, optical, as well as in vitro and ex vivo techniques (e.g. MALDI-IMS, IHC, confocal microscopy). Imaging of tumor models including glioma, colorectal, and breast. Extensive use of quantitative analysis applied to PET imaging data, including compartmental modeling to determine tracer kinetic parameters. Designed and implemented regimen for collection and co-registration of 3-D imaging data sets including PET, CT, MRI, MALDI-IMS, and histology for robust quantitative voxel-by-voxel correlation of measured imaging metrics, anatomical structures, and biological parameters. -
Research FellowMassachusetts General Hospital/Harvard Medical School Mar 2006 - Oct 2009Part of interdisciplinary and highly collaborative team consisting of chemists/medicinal chemists, biologists, engineers, and physicians developing and assessing novel compounds for the treatment and imaging of cancer and inflammation. Focus on pharmacological effects, biodistribution, and intracellular distribution of viridin analogs and antibody-based compounds in both cellular in vitro assays and murine tumor models. Work includes extensive use of in vitro and in vivo cell and tumor proliferation and biodistribution assays, ex vivo analysis of murine tissues, FACS analysis, fluorescence and intravital microscopy, western blotting, and various biological techniques.
Ralph (Adam) Smith, Phd, Mba Education Details
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Entrepreneurship/Innovation Management -
Biomedical Engineering -
Biomedical Engineering
Frequently Asked Questions about Ralph (Adam) Smith, Phd, Mba
What company does Ralph (Adam) Smith, Phd, Mba work for?
Ralph (Adam) Smith, Phd, Mba works for Bristol Myers Squibb
What is Ralph (Adam) Smith, Phd, Mba's role at the current company?
Ralph (Adam) Smith, Phd, Mba's current role is Scientific Senior Director - Imaging.
What schools did Ralph (Adam) Smith, Phd, Mba attend?
Ralph (Adam) Smith, Phd, Mba attended Drexel University's Lebow College Of Business, Vanderbilt University, The Johns Hopkins University.
Who are Ralph (Adam) Smith, Phd, Mba's colleagues?
Ralph (Adam) Smith, Phd, Mba's colleagues are Patrick Vincenten, Kelsy Tinsley, Denise Bennett, Akiko Amakawa, Lorraine Burianek, Jannicia Bullock, Danielle Goodheart.
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