In Ram's 20 years with the pharmaceutical industry and the government, including the Department of Defense (DOD) and the National Institutes of Health (NIH), he has managed multifaceted biomedical research projects involving basic, clinical, applied, and product-oriented research. Throughout his career, Ram has led interdisciplinary research teams engaged in biomarker development and drug discovery and development. At the Department of Defense, he led the effort to create a working group on biomarkers as part of the Prostate Cancer Clinical Trial Consortium (PCCTC), which collaborated with industry, academia, non-profits, and government agencies to devise recommendations for precision medicine in prostate cancer treatment. Currently, Ram is the Program Director of the HEAL (Helping to End Addiction Long-Term) Biomarker Program at NINDS (The National Institute of Neurological Disorders and Stroke), overseeing the NINDS and HEAL pain biomarker research portfolios.