Involved in a program to deliver clinical candidate in diabetes (dual GPCR agonist) • Project leader and lead medicinal chmist of a group of 5 chemists including one Ph.D. • Working on hit identification

• Involved in two programs to deliver two clinical candidates in diabetes (GPR agonist)• Lead medicinal chemist of a group of 5 chemists.• Working on lead optimization to deliver optimized leads for pre-clinical studies• In each program, two lead series were identified with good efficacy and excellent PK properties

Lead medicinal chemist (20 scientist group) of a programme to deliver two clinical candidates in pain (GPCR antagonist)our team presently involved in lead optimization stage and also at lead identification stage for back-up candidate* Arylsulfonamide compounds and uses thereof (patent filed)

 Involved in a medicinal chemistry program for the treatment of cancer (enzyme inhibitors)• Lead chemist of a group of 5 chemists• Team is successfully delivered lead series

 Involved in a medicinal chemistry program for the treatment of fungal & bacterial infections • Synthesized new boron containing NCE’s for the program• Optimized the process for the synthesis of a pre-clinical candidate (GSK2251052) for clinical studies Involved in a medicinal chemistry program for the treatment of cancer (GPCR agonist)• Synthesized new NCE’s for the programPre-clinical Chemistry of GSK2251052: A First in Class Boron-Containing Antibacterial AgentV. Hernandez, S. Baker, J. Plattner, M. R. K. Alley, V. Anchoori, M. Anugula, S. Kingsley, Ramesh Patnam, S. Reddy, R. Sharma, I. Sidhu, R. Singh, R. Subedi, H. Zhang, J. G. Philips, L. Penicott, J. Hanko, E. Eksteen, N. Vaidya, and J. A. Nieman33rd National Medicinal Chemistry Symposium, Tucson, AZ, May 20-23, 2012.

• Optimized process for the synthesis of Loxapine (dibenzoxazepine, antipsychotic agent). • Synthesized the deuterated bioactive molecues, Fosinoprilat-D5 (ACE inhibitor) and Atrovastatin-D5 (lipid-lowering agent)• Synthesis of bioactive molecules and their intermediates (PO based projects)