Ramkrishna De Email & Phone Number

San Diego, CA, US

San Diego, CA, US

• Synthesized and optimized a lead compound for a new scaffold in an Oncology project
• Designed, synthesized, and optimized a lead compound for the HIV project
• Filed six provisional patents on potential lead compounds for Respiratory Syncytial Virus, Oncology, and HIV

Boston, MA, US

• Synthesized and optimized lead compound for a new scaffold in a Cystic fibrosis project
• Explored an amide coupling methodology with parallel synthesis and high throughput chemistry to prepare libraries of compounds
• Prepared documents and filed two provisional patents on cystic fibrosis

Indianapolis, Indiana, US

• Lilly Life Sciences Studio (L2S2), Automation chemistry
• Optimized metal-catalyzed coupling reactions that resulted in improved yield, ease of synthesis in parallel microwave reactors.
• Validated Solid Phase Extraction (SPE) method using ion exchange resins for Lilly Life Sciences Studio.
• Proficient in reaction work-up through solid-phase extraction (cation exchange, reverse phase) for a variety of compounds including basic, neutral and acidic compounds.
• Extensive experience in purification by Combiflash (Teledyne Isco, both reverse phase, and normal phase) and preparative HPLC.
• Generated a library of Amide coupling products.

Bloomington, Indiana, US

• Developed a high yielding improved route for several linear and cyclic peptides (11 mer) targeting drug-resistant bacteria via solid phase peptide synthesis ( SPPS)
• Developed a new route for the convenient scale-up of β-hydroxy asparagine, which is prevalent in several antibacterial polypeptides. Existing routes were not amenable to scale up
• Developed shorter and high-yielding routes for scale-up of several unnatural amino acids including phenyl serine derivative, allo-threonine, hydroxy leucine, and β-hydroxy aspartic acid.
• Developed and implemented analytical methods for the purification and characterization of peptides via HPLC

• Production and isolation of natural weight loss products
• Developed and established an efficient method for pilot-scale production of 5 kilograms of (RASPBERRY KETONE and GARCINIA CAMBOGIA), a natural weight loss product
• Developed a method for the isolation and purification a kilogram of appetite suppressant (chlorogenic acids) from natural sources including coffee beans.
• Prepared certificate of analysis for different nutritional companies in an ACLASS ISO 17025 certified laboratory environment
• Proficient in writing SOP
• Mentored and coached two co-op undergrad students for synthesis and analysis

New York, NY, US

Taught organic chemistry courses to pre-medical students

Bloomington, Indiana, US

• Natural product synthesis and Methodology development
• Synthesized macrolactone core of amphidinolide C, C2 & F via Yamaguchi macrolactonization and Stille cross coupling
• Developed a concise methodology for the construction of common motifs (nonracemic cis- and trans-2,5-disubstituted tetrahydrofurans) of anti-tumor macrolactone amphidinolide. This was then applied towards the total.
• Developed a high yielding route for the synthesis of Katsuki catalyst thereby reducing cost and time
• Established the structure of the amphidinolide macrolactone, using a low and high-temperature NMR

Atlanta, GA, US

• Collaborated with physical chemistry group for studying electron transfer rates of metal complexes
• Redesigned synthetic route to provide high yielding Re (I) complexes for electron transfer studies.
• Mentored undergraduate students in the research lab

Project Management Certificate Program, Project Management

Doctor Of Philosophy (Ph.D.), Organic Chemistry

Organic Chemistry

Master'S Degree, Organic Chemistry