Ramkrishna De

Ramkrishna De Email and Phone Number

Senior Scientist at Cidara Therapeutics @ Cidara Therapeutics
Ramkrishna De's Location
San Diego, California, United States, United States
Ramkrishna De's Contact Details
About Ramkrishna De

An accomplished Senior Scientist with extensive experience in small molecule design and optimization for disease targets, including Cystic Fibrosis, HIV, RSV, and oncology. My career showcases expertise in modern and classical synthetic methods, resulting in the successful delivery of compounds into clinical trials. Additionally, I have effectively overseen Contract Research Organizations (CROs), ensuring seamless collaboration and adherence to project timelines. My educational background includes a Ph.D. in Organic Chemistry, and I possess a strong skill set in small molecule and peptide synthesis, analytical techniques, and regulatory compliance. I am committed to driving innovation in pharmaceutical research and am eager to contribute my expertise to groundbreaking projects in the industry.

Ramkrishna De's Current Company Details
Cidara Therapeutics

Cidara Therapeutics

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Senior Scientist at Cidara Therapeutics
Ramkrishna De Work Experience Details
  • Cidara Therapeutics
    Senior Scientist
    Cidara Therapeutics Jan 2021 - Present
    San Diego, Ca, Us
    • Synthesized and optimized a lead compound for a new scaffold in an Oncology project• Designed, synthesized, and optimized a lead compound for the HIV project • Filed six provisional patents on potential lead compounds for Respiratory Syncytial Virus, Oncology, and HIV
  • Vertex Pharmaceuticals
    Research Scientist I, Medicinal Chemistry
    Vertex Pharmaceuticals Nov 2019 - Dec 2020
    Boston, Ma, Us
    • Synthesized and optimized lead compound for a new scaffold in a Cystic fibrosis project• Explored an amide coupling methodology with parallel synthesis and high throughput chemistry to prepare libraries of compounds• Prepared documents and filed two provisional patents on cystic fibrosis
  • Eli Lilly And Company
    Synthetic Chemist
    Eli Lilly And Company Sep 2018 - Jun 2019
    Indianapolis, Indiana, Us
    Lilly Life Sciences Studio (L2S2), Automation chemistry• Optimized metal-catalyzed coupling reactions that resulted in improved yield, ease of synthesis in parallel microwave reactors.• Validated Solid Phase Extraction (SPE) method using ion exchange resins for Lilly Life Sciences Studio.• Proficient in reaction work-up through solid-phase extraction (cation exchange, reverse phase) for a variety of compounds including basic, neutral and acidic compounds.• Extensive experience in purification by Combiflash (Teledyne Isco, both reverse phase, and normal phase) and preparative HPLC.• Generated a library of Amide coupling products.• Familiarity with the Chemspeed Autosuite software.• Proficient in Biotage Initiator microwave reactor• As a member of the automated chemistry team compiled in-house progress reports and presentations.
  • Indiana University
    Post Doctoral Associate
    Indiana University May 2015 - Apr 2017
    Bloomington, Indiana, Us
    • Developed a high yielding improved route for several linear and cyclic peptides (11 mer) targeting drug-resistant bacteria via solid phase peptide synthesis ( SPPS)•Developed a new route for the convenient scale-up of β-hydroxy asparagine, which is prevalent in several antibacterial polypeptides. Existing routes were not amenable to scale up•Developed shorter and high-yielding routes for scale-up of several unnatural amino acids including phenyl serine derivative, allo-threonine, hydroxy leucine, and β-hydroxy aspartic acid.•Developed and implemented analytical methods for the purification and characterization of peptides via HPLC
  • Natural Products Analytics Group
    Research Chemist
    Natural Products Analytics Group Sep 2012 - Jan 2015
    Production and isolation of natural weight loss products • Developed and established an efficient method for pilot-scale production of 5 kilograms of (RASPBERRY KETONE and GARCINIA CAMBOGIA), a natural weight loss product • Developed a method for the isolation and purification a kilogram of appetite suppressant (chlorogenic acids) from natural sources including coffee beans.• Prepared certificate of analysis for different nutritional companies in an ACLASS ISO 17025 certified laboratory environment• Proficient in writing SOP• Mentored and coached two co-op undergrad students for synthesis and analysis
  • The Princeton Review
    Instructor
    The Princeton Review Jan 2012 - Dec 2012
    New York, Ny, Us
    Taught organic chemistry courses to pre-medical students
  • Indiana University Bloomington
    Graduate Student, Ph.D.
    Indiana University Bloomington 2005 - 2012
    Bloomington, Indiana, Us
    Natural product synthesis and Methodology development • Synthesized macrolactone core of amphidinolide C, C2 & F via Yamaguchi macrolactonization and Stille cross coupling• Developed a concise methodology for the construction of common motifs (nonracemic cis- and trans-2,5-disubstituted tetrahydrofurans) of anti-tumor macrolactone amphidinolide . This was then applied towards the total synthesis of Amphidinolide C• Developed a high yielding route for the synthesis of Katsuki catalyst thereby reducing cost and time• Established the structure of the amphidinolide macrolactone, using a low and high-temperature NMR
  • Emory University
    Graduate Student
    Emory University Aug 2003 - Aug 2005
    Atlanta, Ga, Us
    • Collaborated with physical chemistry group for studying electron transfer rates of metal complexes• Redesigned synthetic route to provide high yielding Re (I) complexes for electron transfer studies.• Mentored undergraduate students in the research lab

Ramkrishna De Skills

Organic Chemistry Nmr Chemistry Organic Synthesis Hplc Spectroscopy Uv/vis Chromatography Mass Spectrometry Research Lc Ms Purification Analytical Chemistry Biochemistry Ftir Protein Chemistry R&d Gas Chromatography Ir Science Organometallic Chemistry Medicinal Chemistry Gc Ms Nuclear Magnetic Resonance Synthetic Chemistry Uv/vis Spectroscopy Natural Products Research And Development Leadership Synthetic Organic Chemistry High Performance Liquid Chromatography Liquid Chromatography Mass Spectrometry Isolation Of Natural Products

Ramkrishna De Education Details

  • San Diego College Of Continuing Education
    San Diego College Of Continuing Education
    Project Management
  • Indiana University Bloomington
    Indiana University Bloomington
    Organic Chemistry
  • Emory University
    Emory University
    Organic Chemistry
  • Indian Institute Of Technology, Bombay
    Indian Institute Of Technology, Bombay
    Organic Chemistry

Frequently Asked Questions about Ramkrishna De

What company does Ramkrishna De work for?

Ramkrishna De works for Cidara Therapeutics

What is Ramkrishna De's role at the current company?

Ramkrishna De's current role is Senior Scientist at Cidara Therapeutics.

What is Ramkrishna De's email address?

Ramkrishna De's email address is rd****@****lly.com

What is Ramkrishna De's direct phone number?

Ramkrishna De's direct phone number is +181232*****

What schools did Ramkrishna De attend?

Ramkrishna De attended San Diego College Of Continuing Education, Indiana University Bloomington, Emory University, Indian Institute Of Technology, Bombay.

What are some of Ramkrishna De's interests?

Ramkrishna De has interest in Science And Technology.

What skills is Ramkrishna De known for?

Ramkrishna De has skills like Organic Chemistry, Nmr, Chemistry, Organic Synthesis, Hplc, Spectroscopy, Uv/vis, Chromatography, Mass Spectrometry, Research, Lc Ms, Purification.

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