Ramu Y Email & Phone Number

Vijayawada Area, India

Preparation of Study Protocols for screening the efficacy and safety of various herbal compounds.Initiation and Conducting the studies according Good laboratory Practice principles and act as study director for various studies.Development of new animal models for pain and inflammation,metabolic diseases and various CNS disorders.Preparation of study reports.Screening of herbal compounds by using :Carrageenan induced inflammatory pain in rats.TPA induced posoriasis in balb c mice.Screening of herbal compounds for CVS safety by using :L-NAME induced hypertension in rats by using tail cuff method.

Jeedimetla Hyderabad

Preclinical Drug discoveryScreening of Novel chemical entities in behavioral pharmacology in Cognition, Depression, Anxiety and Psychosis areas by Forced swim test (Depression) Tail suspension test (Depression) Novelty induced hypophagia (Depression) Dominant submassive task (Depression) Novel object recognition task (Cognition) T-maze task (Cognition) Radial arm maze task (Cognition) Passive avoidance task (Cogntion) Social recognition task (Cognition) Vogel conflict test (Anxiety) Elevated T-maze (Anxiety) Open field task (Anxiety) Elevated plus maze test (Anxiety) MK-801 induced hyper locomotion (Psychosis) MK-801 induced stereotypic behaviour (Psychosis) Anti convulsant activity. Screening of Novel chemical entities in metabolic disorders by STZ-induced diabetes in adult rats (Type-I) High fat + STZ model (Type-II) Nicotinamide +STZ model (Type-II) Multiple low dose STZ-induced diabetes in mice (Type-I) Oral glucose tolerance test in mice, rats High fat diet studies in mice, rats Bulimia nervosa (Binge eating study) Acute food intake studiesScreening of Novel chemical entities in Pain and Inflammation Carrageenan-induced paw edema. CFA adjuvant – induced inflamatory pain. Formalin induced acute pain in rats. Tail flick method. Hot plate method. Acetic acid induced writhing in mice. Partial Sciatic nerve ligation. Sciatic nerve ligation. Chronic constriction injury. Capsaicin induced hyperalgesia and allodynia Incision induced pain model Chemotheraphy induced neuropathic pain. Streptozocin induced diabetic neuropathic pain. Adjuvant induced arthiritis in rats. Mono iodo acetate induced arthiritis in rats.Screening of Novel chemical entities in Safety models by Rota rod, GI safety models of gastric emptying, GI transit, GI secretion and GI irritation, CVS, respiratory.

Hyderabad Area, India

 Scientific data compilation, Statistical analysis and Report writing Preparation of draft / final protocols & Reports Expert in handling of preclinical species viz., Rat, Mice and Guinea pig etc. Expert in Randomising the animals and also expert in dosing of various animal species by different routes of administration like p.o., i.p., s.c., i.v. etc. Blood collections through retro orbital pad rupture, cadiac puncture and tail vein. Expert in canulating jugular,carotid artery veins. Handful of experience in setting up & Optimisation of methods useful in preclinical screening of NCE’s. Expert in handling of Dynamic plantar aesthesiometer, Randall selitto,von frey filaments. Proficiency in data base and Statistics like Graph pad prism 4.0 & 5.0  Proficiency in Microsoft office and Video Tracking System(TSE) for recording Animal Behaviour

Hyderabad Area, India

Hyderabad Area, India

Development of various animal models for pain and inflammation.

M.Pharmacy, Pharmacology, First Class

M. PHARM DISSERTATION: “STUDIES ON POLYMORPHISMS OF MDR1 GENE IN CERVICAL CANCER CASES AND CONTROLS” Held in “INDO-AMERICAN CANCER.

Bachelor Of Pharmacy (B.Pharm.), Pharmaceutical Sciences, First Class

D.Pharmacy, Pharmacy