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Non- coding regions of DNA has been increasing since majority of genes are transcribed into non-coding RNA. Scientific data reveal the regulatory role of lncRNA in the control of gene expression during cell development and homeostasis. So far only few lncRNA have characterized in cellular and developmental process. So these molecules will have possibility to be used as biomarkers. Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer