Raphael Sommer Email & Phone Number

Boudry, Neuchâtel, Suisse

Bâle, Suisse

Bâle, Suisse

Basel Area, Switzerland

Lausanne Area, Switzerland

My mission was to provide support to the phase I clinical study manager for the development of the new anti-tubercular drug macozinone. My expertise in microbiology serves for the translation of numerous concepts between experiments conducted in the laboratory and the clinics (e.g. preclinical efficacy in rodents, pharmacodynamics, etc.). Visit www.im4tb.org for more information.

Lausanne Area, Switzerland

I realized my PhD in the Laboratory of Microbial Pathogenesis, under the supervision of Prof. Stewart T. Cole and Prof. Andy Oates.Tuberculosis (TB) remains one major cause of death worldwide due to a single pathogenic agent, Mycobacterium tuberculosis, and the emergence of drug-resistant bacteria urges the need of new antibiotics and treatment strategies. The current protcols to evaluate drug or vaccine efficacy in models of infection are extremely long, expensive and tidious. To circumvent these drawbacks, we are investigating several models of tuberculosis infection with the aim to improve their application in drug discovery and development. For example, by implementing an in vivo optical imaging platform, one could evaluate the progression of the disease in mice infected with Mycobacterium tuberculosis and follow up the effect of a new treatment in real time. Alternatively, zebrafish proved to be excelent models to study tuberculosis. Experimental infection in zebrafish embryos with Mycobacterium marinum replicates the initial stages of human TB. The simplicity of this model makes it an affordable system to evaluate the efficacy of new anti-TB drugs and can be easily adapted to a high-throughput in vivo model for drug discovery. Those approaches aim to fasten the discovery of new treatments and vaccines against TB and follow the ethical recommendations of the 3R's policy.

Région De Washington D.C. Metro, États-Unis

Production, purification and study of recombinant proteins, in order to investigate their roles in tumor development.Competences in PCR, molecular cloning, expression and purification of recombinant proteins, affinity studies (Isothermal Titration Calorimetry).

Région De Lausanne, Suisse

Contribution to the development of an optimized formulation for a poorly soluble API and excipients screening.Competences: organisation and team work, solubility analyses, analytical chemistry (HPLC), basics in formulation an galenics.

Doctor Of Philosophy - Phd, Molecular Life Sciences

Advisors: Prof. Stewart T. Cole and Prof. Andy Oates. Focus on microbiology, drug discovery, antibiotics, tuberculosis, molecular biology.

Master Of Science (Msc), Life Sciences And Technology

Orientation in Molecular Medicine Competences in disease biology (cancer, infection, immunology) and pharmacology. Aquired innovative.

Bachelor Of Science (Bsc), Chimie Et Génie Chimique