Rasool Saghaleyni Email & Phone Number

Switzerland

Sweden

As a bioinformatics scientist currently working at NBIS – National Bioinformatics Infrastructure Sweden – I am supporting various computational biology projects within academic research groups in Sweden. In this position, I have honed my data analysis skills across multiple bioinformatics disciplines, including spatial transcriptomics, biomarker discovery, understanding drug mechanisms of action, and identifying new drug candidates. My experience has also allowed me to excel in reporting and presenting analysis results clearly and understandably to diverse audiences.Responsibilities include:* Bioinformatics support of research projects* Training duties* Report preparation and documentation* Scinetific presentation

Gothenburg, Vastra Gotaland County, Sweden

Since its invention in 2012, CRISPR technology has transformed the face of life science by enabling the generation of thousands of cell lines originating from a wide range of tissues and a myriad of transgenic animals recapitulating disease phenotypes. Huge excitement around the revolutionary aspects of CRISPR-based studies and increasing support from funding agencies have translated into the number of edited cell lines vastly growing every year. The annotation of CRISPR-related articles and extraction of key content has traditionally relied on manual efforts. Manual annotation is error-prone and time-consuming. We explored a novel approach to keyphrase extraction in CRISPR-related articles by harnessing transfer learning and pre-trained Transformer models, specifically Sentence Transformers. Through fine-tuning with a specialized dataset containing articles and key sentences, this study showcases the effectiveness of these models, achieving an impressive Average R-precision of 90.4%. Time savings and workflow efficiency enhancements make this methodology highly valuable in information retrieval. AddCell provides the research community, legislators, regulators, and the general public with a large and in-depth overview of the current status of CRISPR-edited cell lines. Responsibilities include: * Project Management * Natural Language Processing (NLP) * Web Development * Team Management * Project Planning * Fundraising * Supervision of master's students * Pitching

Gothenburg Metropolitan Area

During my postdoctoral tenure, I spearheaded the development and application of the HumanSec toolbox to model cellular protein production processes. This initiative centered on utilizing proteomics data linked to Alzheimer’s disease with the objective of elucidating pathways influencing the amplification and advancement of AD. Throughout this project, I refined my proficiency in package development, specializing in modeling protein secretion, and deepened my comprehension of the complex biological mechanisms underpinning brain neurology.Responsibilities include:* Cancer Biology* Protein secretion modeling* Metabolic modeling* Brain Neurology* Biomarker/drug discovery* Multi-omics data integration and analysis

Title: Systems Biology of Protein Secretion in Human Cells – Multi-omics Analysis and Modeling of the Protein Secretion Process in Human Cells and its Applications.My doctoral thesis focused on elucidating the intricate process of protein secretion within human cells and its significance in both medical advancements and disease understanding. I delved into the complexities of how cells produce and release proteins, vital for various functions including hormone signaling and disease development. By employing high-throughput molecular profiling techniques, I examined the inner workings of protein secretion components within cells. Utilizing computational models, I deciphered how alterations in these components impact protein production outcomes. My research identified key genes crucial in optimizing pharmaceutical protein production and highlighted potential biomarkers and drug targets for diagnosing and treating conditions like cancer.Responsibilities include:* Cancer Biology* Protein secretion modeling* Metabolic modeling* Brain Neurology* Biomarker/drug discovery* Multi-omics data integration and analysis* Supervision of master’s students* Teaching Assistant* Course development* Project planning

Cross Tajbakhsh Street, 24Th Kilometer Makhsous, Tehran - Iran . Aryogen Pharemd

I was working in the PD (Process Development) department at AryoGen Biopharmed Company. More specifically, I was involved in designing bio-assay tests for evaluating the binding potency of monoclonal antibodies and was additionally involved in developing chromatographic methods to quantify and control the quality of the monoclonal antibodies.Responsibilities include:* Expertise in bio-assay design for monoclonal antibody binding assessment.* Developing chromatographic methods for antibody quality control.* Hands-on experience optimizing antibody production processes.

Within the cell culture department of the company, I actively collaborated with the Research and Development (R&D) as well as Quality Control (QC) departments on multiple projects. Together, we aimed to innovate and refine the production processes for optimal outcomes.Responsibilities include:* Mammalian cell culture.* Antibody production.* Antibody production quality control tests.* Developing downstream processes for antibody purification.

Tehran

Project title: Evaluation of cell growth modeling accuracy concerning the biomass production reaction as the objective function in constraint-based reconstruction of metabolic networks.Responsibilities include:* Constraint-based modeling.* Metabolic modeling.* Defining benchmarking concepts for testing metabolic modeling tools.

Doctor Of Philosophy - Phd, Systems And Synthetic Biology

In this thesis, I analyzed multi-omics datasets and investigated the protein secretion process from different perspectives. I used.

Master'S Degree, Cell/Cellular And Molecular Biology

In biology, scientists used to study different parts of biological phenomena distinctly. Still, after inventing sequencing and high.

Bachelor'S Degree, Cell/Cellular And Molecular Biology