Reagan Mcrae, Ph.D. Email & Phone Number

North Carolina, United States

Pre-clinical toxicologist providing scientific expertise in in vitro studies to support the development and marketing of the company's portfolio of consumer products.- Subject Matter Expert in nonclinical toxicology studies including cell-based in vitro assays, providing recommendations on regulatory and mechanistic toxicology testing as part of of the toxicological risk assessment for potential products- Identify gaps and support the development of nonclinical toxicology capabilities with external contract research organizations using both standardized and New Alternative Methods testing tools- Act as a Study Sponsor/Monitor on externally contracted studies: design, monitor, interpret, and report for internal communication(s) and regulatory submissions- Identify and qualify external CROs for regulatory and foundational cytotoxicity, genotoxicity, and mechanistic studies; scope and manage projects; implement various test systems including primary cells, organotypic models, and iPS-derived cell types in standardized and mechanistic assays

Winston-Salem, North Carolina, United States

Technical team member within the organization focused on assisting with the outsourcing, design, study oversight, and interpretation of in vitro toxicological studies to support product development and regulatory submissions within S&RA.• Monitor CROs for technical capabilities through ongoing discussion and appropriate site visits• Assess performance of CROs in cooperation with management and Procurement partners • Act as a Study Monitor and SME for nonclinical studies • Support PMTA and MRTPA submissions: writing and reviewing nonclinical assay sections of regulatory documents; data interpretation; data presentation• On-board new CRO’s through pilot studies and site monitoring• Maintain expert level knowledge of standard toxicology assays including the Ames Reverse Mutation (AMES)Assay, Neutral Red Uptake (NRU) Assay, In Vitro Micronucleus (IVMN) Assay and Cellular Transformation Assay (CTA) • Identify and validate novel and/or improved regulatory assays as well as more human relevant model systems in which to conduct the assays

Thousand Oaks, California, United States

Work centered upon making direct contributions to early discovery projects to help them advance them through the pipeline. Additionally, led a project which involves the development of a platform designed to identify novel therapeutic targets for heart disease.➜ Continuously advanced programs by developing both in vitro and cellular-based assays in addition to overseeing isolation of cell organelles, pancreatic islet isolation, neonatal rat ventricular cardiomyocyte isolations, viral transduction of cells, insulin secretion assays, ELISA assays, immunofluorescent assays, cardiomyocyte hypertrophy/arrhythmia assays, and RNAi assays ➜ Designed detailed in-vitro model systems using human inducible pluripotent stem cells, human and mouse pancreatic islets, neonatal & adult rat cardiomyocytes, and stable mammalian cell lines

Greater Los Angeles Area

Led project and laboratory operations within a fast-paced environment with a focus on managing multi-functional therapeutic projects. Worked closely with internal team members, consistently built positive rapport within the facility, and ensured standard safety and/or regulatory requirements were followed. ➜ Maintained an extensive knowledge of novel biological techniques to successfully address specific scientific questions in addition to identifying areas of potential improvement➜ Reviewed and analyzed complex data, generated comprehensive reports, and communicated data/results to members of executive leadership

Greater Atlanta Area

Completed post-doctoral work within an educational setting with a concentration on studying metal homeostasis in mammalian cells. Created formal presentations that outlined research progress and provided detailed weekly updates on recently published literature in related fields of research. ➜ Provided training and individualized coaching to new lab members, diffused escalated operational issues, and moderated group research discussions

Ph.D., Chemistry & Biochemistry

Thesis: I. Investigating Metal Homeostasis in Mammalian Cells Using High Resolution Imaging Techniques II. Investigation of Synthetic.

Bachelor Of Science - Bs, Chemistry