Reas Khan Sulaimankutty Email & Phone Number

• Served as principal scientist for various projects, focusing on development of gene therapy to treat retinal/optic nerve degenerative diseases.• Acted as principal scientist for projects, focusing on development of gene editing technology to treat retinal degenerative diseases.• Led evaluation of visual functional recovery using OKR and ERG after treatment strategies.• Used fundoscopy, and OCT to evaluate recovery and tolerability. • Managed gene tolerability and efficacy studies as well as PK and PD of small molecules.• Conducted translational biomarker analysis to evaluate drug efficacy.• Supervised and maintained transgenic mouse colonies as models of retinal and optic nerve degeneration

Philadelphia, Pennsylvania, United States

• Named member of study titled “The Development of Gene Therapy to Treat Chronic Glaucoma as well as “The Development of Gene Therapy Using SIRT1 signaling to Treat Chronic Glaucoma” • Studied mechanism of SIRT1 activator mediated neuroprotection of retinal ganglion cells (NIH project).• Worked on efforts to study anti-inflammatory and neuroprotective effects of novel drugs: ST266 (secretome from amniotic progenitor cells for Noveome Biotherapeutics; MP201 (Mitochon Pharmaceuticals); HE3286 (Harbor Therapeutics); and SRTAW04 (Sirtris, a GSK company) in optic neuritis and Glaucoma models. • Led the study to evaluate mechanism of Mouse Hepatitis Virus (MHV) induced optic neuritis and neural-cell-immune interaction, investigating underlying mechanism of neuroinflammation and demyelination.• Led and drove development of novel therapies using SIRT1 and mitochondrial biogenesis signaling pathways to treat blast and blunt trauma-induced traumatic optic neuropathy.

Philadelphia, Pennsylvania, United States

• Studied mechanism of SIRT1 activator mediated neuroprotection of Retinal Ganglion Cells (NIH project).• Worked on study titled “Neuroprotective effects of ST266 (secretome from Amniotic Progenitor cells) during Experimental autoimmune encephalomyelitis (EAE) animal model of Multiple sclerosis”.

Baton Rouge, Louisiana, United States

Participated in handful of studies: “Anti-convulsive effect of leptin in epilepsy and role of astrocytic leptin receptors in glutamate induced astrogliosis” and “Transport of cytokine through blood brain barrier, Intracellular trafficking of IL-15 and IL-15 receptor α in RBE4 and endothelial cells.” Developed temperature telemetry and EEG sleep recording setup for study of CNS action of cytokine in sleep and temperature regulation.