• Designed, synthesized, scaled up intermediates and final compounds to advance clients drug discovery programs (cannabinoids, psychedelics, covalent inhibitors).• Maintained facility and infrastructure (HVAC/Electrical/Plumbing). Oversaw routine maintenance, emergency repairs, capital improvement needs, facility upgrades and construction.• Oversaw Controlled Substances program. Access, usage, regulatory updates to Health Canada.• Established satellite laboratory to meet headcount expansion and ongoing business demand.• Oversaw EHS/OHS program. Employee compliance, hazardous waste, JHSC, inspections, incident management, dissemination to stakeholders.• Laboratory instrument lifecycle. Procurement, troubleshooting, repair, maintenance, focusing on expenditure reduction whilst building out capabilities.

• Synthesized ligands (phospholanes, aminophosphines, chiral diamines) and catalysts (Rh, Ru, Ir) up to 100's of gram scale. • Significant experience in Schlenk line and glove box techniques for air and moisture sensitive compounds. • Sourced/purchased starting materials and intermediates up to multi-Kg scale. • Client quotations, project scheduling. • Shipping hazardous materials worldwide, TDG and IATA DGR.

• Metabolite synthesis for identification and structure confirmation by LC/MS/MS and scale up for IND enabling toxicology studies. • Determination of PK parameters from plasma samples. • Synthesis of compounds for ARSACS and epilepsy preclinical programs.

Medicinal Chemistry, Nitric Oxide Synthase Inhibitors, Opiates, Designed Multiple Ligands, Pain Therapeutics

Contract medicinal chemistry research, carbohydrate chemistry

Process route development, synthesis of API and impurities.

Process optimization; synthesis, purification up to 1/2 Kg scale;