Current Research Projects: -mRNA affinity-based chromatography strategies to separate large-transcript purifications selectively with AKTA. -HEK293 bioreactor studies to develop improved PAT to measure redox for improved AAV production. -Modeling of high waste cooking oil genetically engineered yarrow lipolytica fermentations for industrial-scale applications Previous Research Projects: -HEK 293 bioreactor PAT development for improved rAAV production by utilizing At-line… Show more Current Research Projects: -mRNA affinity-based chromatography strategies to separate large-transcript purifications selectively with AKTA. -HEK293 bioreactor studies to develop improved PAT to measure redox for improved AAV production. -Modeling of high waste cooking oil genetically engineered yarrow lipolytica fermentations for industrial-scale applications Previous Research Projects: -HEK 293 bioreactor PAT development for improved rAAV production by utilizing At-line and on-line analytics and designing tailored feed strategies during cell expansion to optimize cell density and overall cell health.-QbD study of the production and formulation of mRNA lipid nanoparticles to improve long-term stability with freeze-drying (lyophilization). Analytical methods for this project included HPLC, UV-Vis, Ribogreen, Flow Cytometry, and DLS. -PAT development and CFD modeling for pharmaceutical lyophilization processes focusing on inter-vial drying heterogeneity. -Pharmaceutical freeze-drying model development to reduce heterogeneity and improve control for scale-up.-Additional expertise in bioreactor operations and computational fluid dynamic modeling of these systems (including iPSC stem cells, HEK293 cells, and Yarrowia lipolytica yeast). Show less

The work completed in this study was part of an FDA-sanctioned study to understand how varying manufacturing parameters impacted the cytotoxicity of generic Ambisome-like drug products. Supported liposomal drug product formulation, sample preparation, and analytical characterization. Executed QbD lyophilization and multivariate data analysis to asses freeze drying's impact on product quality. Performed bioassays to understand how varying manufacturing and formulation steps impact… Show more The work completed in this study was part of an FDA-sanctioned study to understand how varying manufacturing parameters impacted the cytotoxicity of generic Ambisome-like drug products. Supported liposomal drug product formulation, sample preparation, and analytical characterization. Executed QbD lyophilization and multivariate data analysis to asses freeze drying's impact on product quality. Performed bioassays to understand how varying manufacturing and formulation steps impact cytotoxicity. Prepared project progress and final reports for the FDA. Show less

Worked with customers to help improve their chemistry for transportation, industrial and furniture & floor coatings.

BASF Catalyst Division - New Ventures is an innovative and exciting division within BASF focusing on novel technologies for new and existing markets and applications. -Technical support and research for chemical facility applications -Technical training for customer applications - Provided engineering support for new and existing customer applications.

BASF Total Petrochemicals, Port Arthur, TX BASF Total Petrochemicals is a joint venture that runs one of the largest steam crackers in the world. Located in Port Arthur, Texas, it is one of the world’s largest producers of ethylene, propylene, and butadiene. During this tenure held a multitude of roles including:-Led project team in a multimillion-dollar cross-facilities project -Responsible for daily operations of 3 plants and supporting utilities