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Richard Knowles is listed as Retired Scientific drug discovery and development consultant at Knowles Consulting, a with 8 employees, based in Milton, England, United Kingdom. AeroLeads shows a work email signal at btinternet.com and a matched LinkedIn profile for Richard Knowles.
Richard Knowles previously worked as Analysome work-flow leader for U-BIOPRED at U-Biopred and Translator in Residence at Imperial College London. Richard Knowles holds Phd, Biochemistry from St. George'S, U. Of London.
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Retired scientific consultant on drug discovery and development, including acting as an scientific assessor for Innovate UK, as well as consultancy for small and large pharma, Venture Capital companies and universities/ academic research groups. Scientific Board member and workflow leader for the Analysome work-flow of the U-BIOPRED severe asthma consortium. Formerly CSO of Peptinnovate and CEO of Arachos Pharma which achieved grant and sought venture funding to progress new oral anti-inflammatories into clinical trials. Specialities: Drug discovery pharmacology and biomarkers and their translation into clinical studiesSevere asthma and asthma segments or phenotypesIn vitro and in vivo models of respiratory and other inflammatory diseasesLeukotrienes and inhibitors thereof; nitric oxide synthases, iNOS; phosphodiesterase 4, PDE4Kinases, other enzyme and receptor targets for drug discovery
Listed skills include Drug Discovery, Pharmacology, Clinical Development, Biomarkers, and 27 others.
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Cambridge, United Kingdom
Has consulted for multiple companies from SMEs to large multinationals, pharmaceutical and venture capital, as well as academic groups, advising on progression of drug discovery projects into clinical studies in the inflammation and respiratory areas.
E.U.
Member of the Scientific Board and responsible for an Analyte Set on the U-BIOPRED severe asthma cohort accessible samples.
London, England
Translator in Residence to the Faculty of Medicine, advising research groups on translating their research by progression into commercial and clinical arenas.
London Marathon
I've only ever run a marathon once before, 10 years ago, so my aspiration is to beat my decade-younger self both on time (4h 22m) and amount raised for asthma UK.I've worked on asthma for much of my professional life, as well as having friends and family who suffer from asthma, some quite badly. Surprisingly every ten seconds someone in the UK has a potentially life-threatening asthma attack and three people die every day. Asthma UK fund work to decrease this burden: https://www.asthma.org.uk/Thanks in advance for any contributions you feel able to make! http://www.virginmoneygiving.com/RichardGKnowlesRichard
Stevenage, United Kingdom
See www.arachos-pharma.com
Europe
Took the lead on behalf of the EFPIA pharma companies in the laboratory models development workstream of the international consortium severe asthma U-BIOPRED project; now continuing involvement as an independent consultant.
Stevenage, United Kingdom
Previously, Director of Clinical Biology at GSK, focussed on asthma. I was the senior biologist for the Refractory Respiratory Inflammation Discovery Performance Unit carrying out biological research to discover and develop new medicines for respiratory diseases, especially asthma & COPD. Under my leadership respiratory biologists played a key role in bringing forward several pre-candidates and candidates which either have entered or are about to enter clinical development. They also set up model systems such as chronic asthma and rhinitis animal models and human tissue- and cell- based assays, provided pre-clinical MRI expertise and technology across disease indications, and provided a major link between biology and clinical scientists, especially in the identification and development of biomarkers for candidate medicinesI took the lead biologist role in in-licensing the Amira FLAP inhibitors into GSK and subsequently in progressing this project to transition into Medicine Development. I had lead roles in providing scientific guidance and biology support to the three full development teams within Respiratory including Breo/ Relvar, recently approved by the FDA. I led a biomarker discovery programme to seek biomarkers of sputum cell-defined asthma phenotypes.Previous experience and publications have covered multiple therapeutic areas including cardiovascular and critical care, metabolism, CNS and cancer.
Led a department of >50 scientists in seeking new respiratory candidate medicines
Positions of increasing responsibility and leadership in Enzyme Pharmacology and In Vitro Pharmacology drug discovery biology departments
Drug discovery research scientist and programme leader
Activities and Societies: PhD on cell signallingPhD on The Mechanism of Action of Vasopressin on Hepatic Metabolism... on cell signalling.
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Richard Knowles works for Knowles Consulting.
Richard Knowles is listed as Retired Scientific drug discovery and development consultant at Knowles Consulting.
AeroLeads has found 1 work email signal at @btinternet.com for Richard Knowles at Knowles Consulting.
Richard Knowles is based in Milton, England, United Kingdom while working with Knowles Consulting.
Richard Knowles has worked for Knowles Consulting, U-Biopred, Imperial College London, Peptinnovate Ltd, and Asthma Uk.
Richard Knowles's colleagues at Knowles Consulting include Tony Jackeson and Juana Schoch.
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Richard Knowles holds Phd, Biochemistry from St. George'S, U. Of London.
Richard Knowles is listed with skills including Drug Discovery, Pharmacology, Clinical Development, Biomarkers, In Vitro, Pharmaceutical Industry, Translational Medicine, and Biochemistry.
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