Richard Liang, Ph.D Email and Phone Number
Richard Liang, Ph.D work email
- Valid
Richard Liang, Ph.D personal email
Innovating at the intersection of technology and life sciences, I lead Dimensional Rxolution with a mission to revolutionize the approach to developing therapies for human diseases. With a foundation rooted in the wisdom of Ralph W. Emerson - “Do not go where the path may lead; go instead where there is no path and leave a trail.” My career is a testament to pioneering HTS funnels and industrialization strategies that simplify, demystify, and make accessible the intricate pathways of disease progression. My expertise spans over 17 years in translational neuroscience: algorithms development using bioinformatics and advanced ML techniques to improve patient stratification, predictive diagnostics, treatment effects simulation, and target-pathway discovery solutions; building HTS-based disease modeling, drug discovery, and biomarker development platforms to unravel pathogenic mechanisms for advancing various therapeutic modalities from target identification to clinical trials.At Dimensional Rxolution, we aim for innovation and achieve it by harnessing cutting-edge data analysis to improve clinical outcomes. Our consultative approach is tailored by leveraging industry experience with robust ML programming to guide our clients through the maze of preclinical development with clarity and strategic foresight. From disease modeling to biomarker development, our work aims to refine the precision of diagnostics and therapeutics.As a leader, my philosophy revolves around fostering a brainstorming environment that cultivates a collaborative, thriving team spirit. Our achievements at Dimensional Rxolution are milestones and stepping stones towards a future where treating neurological disorders is as precise as effective. Join us on this journey as we pave the way for a new era in medical science.Expertise areas:CNS diseases: PD, AD, HD, ALS, FTD, dystonia, ataxia, chorea, spongiform encephalopathies.Pathology: Neurodegeneration, neuroinflammation, demyelination, aberrant homeostasis (lysosome, autophagy), mitochondrial dysfunction, cell motility, tumorigenesisHTS-based drug discovery: Disease modeling and biomarker development platforms, immunoassays (MSD, Simoa, AlphaLISA), High-content Imaging (IHC, ICC, ISH), Genetic perturbation (CRISPR, ASO, exosome, viral particles)Drug development: Lead optimization, Biomarker development, IND-enabling, Ph1 clinical trial (FIH)Multi-omics: scRNAseq, bioinformatics, statistics, machine learning (R, Python, SQL)Primary cell culture: iPSCs, neurons, astrocytes, oligodendrocytes, microglia, hepatocytes, lymphoblasts
-
Director, Translational MedicineGraphen DrugomicsNew York, Ny, Us
-
Scientific DirectorProject Mosaic Sep 2024 - Present -
FounderDimensional Rxolution Nov 2023 - PresentAs a principal founder of Dimensional Rxolution, I have established this organization specializing in preclinical discovery and development for human disease therapies. My team offers data-driven solutions tailored to our client's drug development and in-vitro diagnostics needs. The screening funnels include disease modeling, target/pathway biology investigation, toxicity assessment, in vitro/ex vivo/in vivo biomolecular assay development, target selection, lead optimization, drug delivery optimization, in vivo efficacy research, biomarker discovery, and patient stratification strategy. We also provide consultations for setting up state-of-the-art research environments, encompassing cell culture, animal vivarium, and automated screening systems for mid to ultra-high throughput. - Leadership in Business Development: Successfully acquired and managed key client relationships within the first quarter, leading to an expansion of the company's client base and a marked increase in project engagements within a short period. - Leadership in Data Analysis and Consulting: Utilizing comprehensive R and Python data analyses to deliver critical insights, enhancing our clients' decision-making processes in preclinical development. Key services include high-content imaging analysis, functional genomics (including microarray, xRNA-seq differential gene expression, Over Representation Analysis, Gene Set Enrichment Analysis), pharmacokinetics (ADMET-PK), and pharmacodynamics (PD) interactions. - Company’s Pipeline Innovation: Directing the design and development of a pioneering biomarker-surveillance solution for neurological diseases, by integrating human-centric data with machine-learning-powered technology. This automation system aims to predict disease penetrance and onset age in patients, contributing to the advancement of precision medicine.We welcome you to contact us to learn how we can help you expedite your drug's market entry efficiently and effectively.
-
Senior Scientist Ii (Translational Neuroscience)Recursion Feb 2022 - Nov 2023Salt Lake City, Utah, Us -
Biomarker ScientistDenali Therapeutics Feb 2019 - Feb 2022South San Francisco, California, Us•Delivered product differentiation recommendations, biomarker data from fluid and imaging for IND-enabling package by designing and executing translational biomarker strategies (i.e. target engagement,identification of pharmacodynamic-, safety-, and predictive-biomarkers)•Validated in progressing molecules into lead optimization through functional genomics tactics (transcriptomics, proteomics, lipidomics, secretomics), automated HTS enabling technologies (MSD, Simoa, ELISA, Fluidigm), primary mammalian cell culture (human- and NHP- PBMC/macrophage), mammal tissues (brain, CSF, plasma), and biostatistical analysis (R, Prism)•Managed CROs for analytical validation of biomarker assays•Prepared translation-related sections in IND and published biomarker findings in 4 studies (EMBO Mol Med, bioRxiv, Mol Neurodegener, Nat. Neurosci) -
Editorial Board Of Scientific ReportsNature Research (Publishing) May 2018 - Feb 2019London, Greater London, Gb -
Research Assistant Professor (Faculty Member)University Of Michigan Medical School Aug 2017 - Feb 2019Ann Arbor, Mi, Us• Identified the druggability for 3 phenotype modifier genes that affect disease penetrance and expressivity in isolated dystonia by directing collaborative research teams with IBM T.J Watson Research Center and Washington University in St. Louis to drive High- Throughput Imaging screening on CRISPR-modified neurons • Validated Tor1b as gene therapy for dystonia mouse models by designing and executing histopathological and behavioral analyses • Deep understanding of neuronal differentiation, autophagy pathway, ubiquitin–proteasome system, and liver lipid metabolism • Hands-on experience with primary mammalian cell culture (ESC, NSC, MEF, cortical neurons, hippocampal neurons, cerebellar neurons, glia, hepatocytes), CRISPR, microscope technology (TEM, fluorescence), and high-throughput imaging • Published 3 studies in HMG, JCI, eLife -
Research Investigator (Faculty Member)University Of Michigan Medical School Oct 2013 - Jul 2017Ann Arbor, Mi, Us• Discovered disease pathogenesis of dystonia (DYT1 and DYT6), identified proteinopathies (K-ɛ-GG) profiling (collaborated with Genentech), and characterized transcriptomic changes in developmental neurodegenerative movement disorders by generating first-in-class in-vivo models which well mimics human behavioral deficiency, disease onset, and penetrance • Strong understanding of CNS development, ubiquitin–proteasome system, lipid droplets, oligodendrocyte differentiation, and the myelination process • Hands-on experience with in-vivo genetic engineering, histopathologic techniques (IHC, IF, ISH, TUNEL, EdU birth dating), cell differentiation, and microscope technology (Stereology, TEM, fluorescence) • Published 3 studies in JCS, Cell reports, and Developmental Cell
-
Postdoctoral Research FellowUniversity Of Michigan Medical School Feb 2011 - Oct 2013Ann Arbor, Mi, Us• Discovered autophagy/autophagosome required for self-renewal and differentiation of postnatal neural stem cells through activation of mitophagy • Designed and generated in-vivo murine models for isolated dystonia (DYT1, DYT6) and developmental ventriculomegaly for investigating disease pathogenesis • Detailed knowledge of adult neurogenesis, autophagy/mitophagy process, and neurodegeneration • Hands-on experience with histopathologic techniques (IHC, IF, TUNEL), microscope technology (TEM, fluorescence), neurosphere culture, neural differentiation, and in-vivo genetic engineering (Cre-LoxP approaches) • Published 1 studies in Nature Neuroscience
-
The University Of Michigan'S Institutional Animal Care And Use Committee (Department Representative)University Of Michigan Sep 2014 - Jun 2017Ann Arbor, Michigan, Us• Evaluating and review procedures in animal use protocols for research and training weekly (~5 protocols/week) to ensure compliance with applicable standards, policies, and regulations at the University of Michigan• Approving or withholding approval of initial, renewed, or revised, applications to use animals in research and teaching• Suspending activities not conducted in compliance with federal or university regulations, requirements, and guidelines• Inspecting the university's animal facilities and study areas• Providing continuing training required for personnel working with animals -
Postdoctoral FellowRockefeller University Oct 2009 - Jan 2011New York, Ny, Us• Identified PKA and GSK3β activation primarily mediating developmental neurogenesis under the tissue plasminogen activator and plasminogen proteolytic cascade in fetal alcohol syndromes • Strong understanding of neurogenesis and axonal generation signaling • Hands-on experience with histopathologic techniques (IHC, IF) and in-vivo genetic engineering -
Research AssistantNational Chung Hsing University Aug 1999 - Jun 2002Taichung, Tw• Discovered HGF-induced sustained ERK-activation to promote cell migration and a synergistic crosstalk mechanism in HGF-FAK mediated tumorigenesis • Extensive understanding of cell motility, tumorigenesis, and extracellular matrix-growth factor receptor signaling • Hands-on experience with in-vitro genetic engineering, cell transformation (plasmid transfection, adenoviral transduction), microscope technology (confocal fluorescence, time-lapse), and cellular-function analyses (cytoskeleton-dynamics, trans-well chemotaxis migration and invasion, 3D extracellular matrix in-vitro tumorigenesis) • Published 2 studies in JBC -
Battalion S3, S7 And S2, Second LieutenantTaiwan Army Recruit Training Centre, Taiwan Sep 1998 - Sep 1999• Operations officer• Training officer• Intelligence officer (Surrogate)
-
Brigade S3, Second LieutenantTaiwan Army Recruit Training Centre, Taiwan Apr 1998 - Sep 1998• Training officer
-
Undergraduate Student Research AssistantNational Taiwan University Jun 1996 - Jun 1997Taipei, Northern Taiwan, TwDepartment of Agricultural Chemistry, National Taiwan University, Taipei, TaiwanAdvisor: Chia-Yin Lee, Ph.D.• Develop a rapid DNA sequencing technique to identify unknown region of Tn10 gene
Richard Liang, Ph.D Skills
Richard Liang, Ph.D Education Details
-
Cornell UniversityComparative Biomedical Sciences -
R.O.C Millitary AcademyInfantry Division
-
National Taiwan UniversityAgricultural Chemistry
-
Taichung First High School
Frequently Asked Questions about Richard Liang, Ph.D
What company does Richard Liang, Ph.D work for?
Richard Liang, Ph.D works for Graphen Drugomics
What is Richard Liang, Ph.D's role at the current company?
Richard Liang, Ph.D's current role is Director, Translational Medicine.
What is Richard Liang, Ph.D's email address?
Richard Liang, Ph.D's email address is lr****@****ics.com
What schools did Richard Liang, Ph.D attend?
Richard Liang, Ph.D attended Cornell University, R.o.c Millitary Academy, National Taiwan University, Taichung First High School.
What skills is Richard Liang, Ph.D known for?
Richard Liang, Ph.D has skills like Confocal Microscopy, Immunohistochemistry, Cell Culture, Animal Models, Cell Biology, Stem Cells, Rt Pcr, Molecular Cloning, Mouse Models, Western Blotting, Fluorescence Microscopy, Immunoprecipitation.
Free Chrome Extension
Find emails, phones & company data instantly
Aero Online
Your AI prospecting assistant
Select data to include:
0 records × $0.02 per record
Download 750 million emails and 100 million phone numbers
Access emails and phone numbers of over 750 million business users. Instantly download verified profiles using 20+ filters, including location, job title, company, function, and industry.
Start your free trial