Richard Leo Wood, Ph.D. Email and Phone Number
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Computational chemist with experience in various techniques as they pertain to drug design. Programming skills in languages such as Fortran and C++, and familiarity with the languages Perl and Python. Outstanding verbal and written communication skills, having written grant proposals and made presentations at scientific meetings. Experience modeling phospholipids, peptides, peptide nucleic acids, proteins, carbohydrates and small drug-like molecules.Interested in anti-cancer, antibiotic, antinflammatory and central nervous system drug development.Expert knowledge of and experience in the following techniques:- Pharmacophore modeling - Homology Modeling- Binding site identification and evaluation- Docking and Scoring- Structure- and Ligand-based design- Cheminformatics- 3D-QSAR including CoMFA and CoMSIA- Molecular Dynamics simulations- Molecular visualization techniques- Database searches- Property prediction- ADME/Tox prediction- Molecular mechanics, including geometry optimizations and conformational searching- Force Field parameterization and refinement- Quantum mechanics - optimizations, frequency calculations, transition state calculations etc.- Electrostatically Embedded Many Body method- QM/MM calculationsUsed pharmacophore modeling and database searching to discover two potential anti-Parkinson's drug leads. A provisional patent application was filed for these compounds. See "SMALL MOLECULES USED IN TREATING NEUROPSYCHIATRIC DISORDERS"-patent pending.Programs used include: Sybyl, Maestro, Gaussian03/09, PipeLine Pilot, MOE, Pymol, InsightII, Cerius2, Quanta, CHARMM/CHARMm, Spartan, Mopac, Knime, LigPlot etc.Specialties: Computational chemistry, computational medicinal chemistry, cheminformatics, molecular modeling, grant proposal writing, technical writing and editing, teachingmy wiki: https://richardleowood.wikispaces.com/
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Adjunct ProfessorPrairie State CollegeHammond, In, Us -
Adjunct ProfessorPrairie State College May 2018 - PresentChicago Heights, Il -
Adjunct ProfessorIvy Tech Community College Jul 2015 - PresentValparaiso, InCourses Taught:CHEM 101 Introductory ChemistrySCIN 101 Alternative EnergySCIN 111 Physical ScienceDocking small molecules to the dopamine D2 receptor (Parkinson's research) and to GPR55 (epilepsy research). -
High School Chemistry TeacherMunster High School Feb 2017 - Jun 2017Munster, InCourses taught:Chemistry IHonors Chemistry
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Adjunct ProfessorIndiana University Northwest Jan 2016 - May 2016Teaching CHEM 344 Organic Chemistry 2 Laboratory -
Consulting Computational ChemistPettersson And Associates Jan 2011 - Feb 2016Hammond, InDocking, geometry optimization, writing.
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Limited Term LecturerPurdue University Calumet Aug 2013 - Dec 2015Hammond, InCourses Taught:CHEM100 Preparatory ChemistryCHEM115 General Chemistry 1CHEM116 General Chemistry 2CHEM373 Physical Chemistry1Presented a poster entitled, "Preliminary Studies of Cannabidiol Analogues Docked to a Homology Model of The Cannabinoid Receptor CB1" at the recent Faculty Research Day at Purdue University Calumet.Currently working on docking small druglike compounds to GPR55. -
Visiting Assistant ProfessorPurdue University Calumet Aug 2012 - May 2013Hammond, IndianaTeaching General Chemistry, Physical Chemistry and Cheminformatics.
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Consulting Computational ChemistSeeking Opportunities May 2010 - Dec 2010Hastings, MnUsing computational techniques to study the deamination reaction of cytosine as catalyzed by the apobec3g enzyme.Using molecular dynamics simulations and other calculational tools (small molecule property estimation: solubility, dipole moments, log P etc.) to understand the interactions between small molecules and phospholipid (POPC and DMPC) bilayers, i.e. cell membranes.
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Post-Doctoral Research AssociateUniversity Of Minnesota May 2007 - Apr 2010Computer-aided drug design of dopamine D2 receptor modulators, using molecular modeling, bio- and cheminformatics, as well as techniques such as QSAR/QSPR, pharmacophore modeling, and database searching to identify potential new hits. Method validation using quantum mechanical geometry optimizations (CCSD(T), HF, DFT etc.) as benchmarks.Docking and scoring of potential anti-cancer agents to Heat Shock Protein 90 (HSP90); the docking results were used to further design molecules which had improved docking scores.Constrained docking of small molecules to the aromatase enzyme, in a method to better understand its role in steroid synthesis and breast cancer.Selected Publications/Presentations/Provisional Patent applicationsEvaluation of density functional theory, semiempirical molecular orbital (SEMO) theory and molecular mechanics methods for prolyl-leucyl-glycinamide (PLG) analogues targeting the dopamine D2 receptor, R.L. Wood, B. Young-Dixon, R. Johnson; and E.A. Amin, American Chemical Society's 235th National Meeting in New Orleans, LA, April 2008.Modeling of prolyl-leucyl-glycinamide (PLG) analogs that modulate the dopamine D2 receptor: method evaluation, pharmacophore mapping/database searching and 3D-QSAR, R.L Wood, R.L. Johnson and E.A. Amin, Abstracts of Papers, 238th ACS National Meeting, Washington, DC, August 16-20, 2009 COMP-288.Evaluation of density functionals, SCC-DFTB, neglect of diatomic differential overlap (NDDO) models and molecular mechanics methods for prolyl-leucyl-glycinamide (PLG) and structural analogsJournal of Molecular Structure: THEOCHEM, Volume 944, Issues 1-3, 30 March 2010, Pages 76-82 (doi:10.1016/j.theochem.2009.12.026 )"SMALL MOLECULES USED IN TREATING NEUROPSYCHIATRIC DISORDERS"-patent pending. -
Bluebird Nest MonitorHunt Valley Bluebird Boxes, Inc. Apr 2007 - May 2007Monitored Eastern Bluebird nest boxes
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Visiting ScholarDuquesne University Aug 2005 - May 2007Calculation of free energies of binding of carbohydrates to proteins.Use of molecular dynamics simulations in the study of the mechanism of the action of proteins on carbohydrates. Use of principal component analysis (PCA) to simplify and reduce the amount of data, and to determine those residues necessary for the binding and recognition of carbohydrates to proteins. -
Computational ChemistSynvax, Inc. Feb 2004 - Sep 2004Design of potential anticancer and antibiotic drugs and the writing of grant proposals to fund such projects.Presentations:Conformational Analysis of Hexapeptides with High Affinity Binding to ORL1 Receptor, R. L. Wood, D. J. Tuttle, R. W. Jones and A. K. Judd, at the Joint 59th Northwest and 18th Rocky Mountain American Chemical Society Regional Meeting in Logan, UT, June 2004.
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Post-Doctoral AssociateTrinity University Oct 2002 - Jul 2003Quantum mechanical geometry optimizations of peptide nucleic acids (PNAs) as a function of chain length and base type (purine, pyrimidine or both). -
Post-Doctoral AssociateCornell University Sep 2000 - Sep 2002Use of molecular dynamics simulations to understand the role of the linker peptide of the endoglucanase CBHI during the process of the hydrolysis of cellulose by CBHI.Presentations:Molecular Modeling of Cellulose Hydrolysis, T. Rignall, C. McCabe, C. Skopec, R. L. Wood, J. W. Brady, and M. E. Himmel, at the Foundations of Molecular Modeling and Simulation, Keystone Resort, Keystone, CO, July 2003.Molecular Modeling of the T. reesei CBH I linker, T. Rignall, C. McCabe, R. L. Wood, J. W. Brady, and M. E. Himmel, at the 25th Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, CO, May 2003. -
Graduate AssistantUniversity Of Illinois At Chicago 1995 - 2000Molecular dynamics simulations of monolayers of saturated and unsaturated phospholipids, as well as analysis of the trajectories.Presentations:Molecular Dynamics Simulations of the Structural and Dynamic Effects of Double Bonds in Dimyristoyl Phosphatidylcholine and its Monolayers, American Chemical Society's 219th National Meeting in San Francisco, CA, March 2000. -
Research AssistantSyracuse University 1984 - 1987Measurement and interpretation of the vibrational circular dichroism (VCD) spectra of small chiral organic molecules in solution.
Richard Leo Wood, Ph.D. Skills
Richard Leo Wood, Ph.D. Education Details
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University Of Illinois At ChicagoComputational Chemistry -
Physical Chemistry -
University Of Southern MaineChemistry
Frequently Asked Questions about Richard Leo Wood, Ph.D.
What company does Richard Leo Wood, Ph.D. work for?
Richard Leo Wood, Ph.D. works for Prairie State College
What is Richard Leo Wood, Ph.D.'s role at the current company?
Richard Leo Wood, Ph.D.'s current role is Adjunct Professor.
What is Richard Leo Wood, Ph.D.'s email address?
Richard Leo Wood, Ph.D.'s email address is rw****@****msn.com
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What schools did Richard Leo Wood, Ph.D. attend?
Richard Leo Wood, Ph.D. attended University Of Illinois At Chicago, Syracuse University, University Of Southern Maine.
What are some of Richard Leo Wood, Ph.D.'s interests?
Richard Leo Wood, Ph.D. has interest in Drug Design, Birding, Sports, The Beatles, Health, Ligand Protein Interactions, Education, Environment, Science And Technology, Human Rights.
What skills is Richard Leo Wood, Ph.D. known for?
Richard Leo Wood, Ph.D. has skills like Molecular Modeling, Computational Chemistry, Drug Design, Chemistry, Molecular Dynamics, Medicinal Chemistry, Protein Chemistry, Drug Discovery, Cheminformatics, Docking, Bioinformatics, Drug Development.
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