Richard Leo Wood, Ph.D.

Richard Leo Wood, Ph.D. Email and Phone Number

Adjunct Professor @ Prairie State College
Hammond, IN, US
Richard Leo Wood, Ph.D.'s Location
Hammond, Indiana, United States, United States
Richard Leo Wood, Ph.D.'s Contact Details

Richard Leo Wood, Ph.D. work email

Richard Leo Wood, Ph.D. personal email

n/a

Richard Leo Wood, Ph.D. phone numbers

About Richard Leo Wood, Ph.D.

Computational chemist with experience in various techniques as they pertain to drug design. Programming skills in languages such as Fortran and C++, and familiarity with the languages Perl and Python. Outstanding verbal and written communication skills, having written grant proposals and made presentations at scientific meetings. Experience modeling phospholipids, peptides, peptide nucleic acids, proteins, carbohydrates and small drug-like molecules.Interested in anti-cancer, antibiotic, antinflammatory and central nervous system drug development.Expert knowledge of and experience in the following techniques:- Pharmacophore modeling - Homology Modeling- Binding site identification and evaluation- Docking and Scoring- Structure- and Ligand-based design- Cheminformatics- 3D-QSAR including CoMFA and CoMSIA- Molecular Dynamics simulations- Molecular visualization techniques- Database searches- Property prediction- ADME/Tox prediction- Molecular mechanics, including geometry optimizations and conformational searching- Force Field parameterization and refinement- Quantum mechanics - optimizations, frequency calculations, transition state calculations etc.- Electrostatically Embedded Many Body method- QM/MM calculationsUsed pharmacophore modeling and database searching to discover two potential anti-Parkinson's drug leads. A provisional patent application was filed for these compounds. See "SMALL MOLECULES USED IN TREATING NEUROPSYCHIATRIC DISORDERS"-patent pending.Programs used include: Sybyl, Maestro, Gaussian03/09, PipeLine Pilot, MOE, Pymol, InsightII, Cerius2, Quanta, CHARMM/CHARMm, Spartan, Mopac, Knime, LigPlot etc.Specialties: Computational chemistry, computational medicinal chemistry, cheminformatics, molecular modeling, grant proposal writing, technical writing and editing, teachingmy wiki: https://richardleowood.wikispaces.com/

Richard Leo Wood, Ph.D.'s Current Company Details
Prairie State College

Prairie State College

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Adjunct Professor
Hammond, IN, US
Richard Leo Wood, Ph.D. Work Experience Details
  • Prairie State College
    Adjunct Professor
    Prairie State College
    Hammond, In, Us
  • Prairie State College
    Adjunct Professor
    Prairie State College May 2018 - Present
    Chicago Heights, Il
  • Ivy Tech Community College
    Adjunct Professor
    Ivy Tech Community College Jul 2015 - Present
    Valparaiso, In
    Courses Taught:CHEM 101 Introductory ChemistrySCIN 101 Alternative EnergySCIN 111 Physical ScienceDocking small molecules to the dopamine D2 receptor (Parkinson's research) and to GPR55 (epilepsy research).
  • Munster High School
    High School Chemistry Teacher
    Munster High School Feb 2017 - Jun 2017
    Munster, In
    Courses taught:Chemistry IHonors Chemistry
  • Indiana University Northwest
    Adjunct Professor
    Indiana University Northwest Jan 2016 - May 2016
    Teaching CHEM 344 Organic Chemistry 2 Laboratory
  • Pettersson And Associates
    Consulting Computational Chemist
    Pettersson And Associates Jan 2011 - Feb 2016
    Hammond, In
    Docking, geometry optimization, writing.
  • Purdue University Calumet
    Limited Term Lecturer
    Purdue University Calumet Aug 2013 - Dec 2015
    Hammond, In
    Courses Taught:CHEM100 Preparatory ChemistryCHEM115 General Chemistry 1CHEM116 General Chemistry 2CHEM373 Physical Chemistry1Presented a poster entitled, "Preliminary Studies of Cannabidiol Analogues Docked to a Homology Model of The Cannabinoid Receptor CB1" at the recent Faculty Research Day at Purdue University Calumet.Currently working on docking small druglike compounds to GPR55.
  • Purdue University Calumet
    Visiting Assistant Professor
    Purdue University Calumet Aug 2012 - May 2013
    Hammond, Indiana
    Teaching General Chemistry, Physical Chemistry and Cheminformatics.
  • Seeking Opportunities
    Consulting Computational Chemist
    Seeking Opportunities May 2010 - Dec 2010
    Hastings, Mn
    Using computational techniques to study the deamination reaction of cytosine as catalyzed by the apobec3g enzyme.Using molecular dynamics simulations and other calculational tools (small molecule property estimation: solubility, dipole moments, log P etc.) to understand the interactions between small molecules and phospholipid (POPC and DMPC) bilayers, i.e. cell membranes.
  • University Of Minnesota
    Post-Doctoral Research Associate
    University Of Minnesota May 2007 - Apr 2010
    Computer-aided drug design of dopamine D2 receptor modulators, using molecular modeling, bio- and cheminformatics, as well as techniques such as QSAR/QSPR, pharmacophore modeling, and database searching to identify potential new hits. Method validation using quantum mechanical geometry optimizations (CCSD(T), HF, DFT etc.) as benchmarks.Docking and scoring of potential anti-cancer agents to Heat Shock Protein 90 (HSP90); the docking results were used to further design molecules which had improved docking scores.Constrained docking of small molecules to the aromatase enzyme, in a method to better understand its role in steroid synthesis and breast cancer.Selected Publications/Presentations/Provisional Patent applicationsEvaluation of density functional theory, semiempirical molecular orbital (SEMO) theory and molecular mechanics methods for prolyl-leucyl-glycinamide (PLG) analogues targeting the dopamine D2 receptor, R.L. Wood, B. Young-Dixon, R. Johnson; and E.A. Amin, American Chemical Society's 235th National Meeting in New Orleans, LA, April 2008.Modeling of prolyl-leucyl-glycinamide (PLG) analogs that modulate the dopamine D2 receptor: method evaluation, pharmacophore mapping/database searching and 3D-QSAR, R.L Wood, R.L. Johnson and E.A. Amin, Abstracts of Papers, 238th ACS National Meeting, Washington, DC, August 16-20, 2009 COMP-288.Evaluation of density functionals, SCC-DFTB, neglect of diatomic differential overlap (NDDO) models and molecular mechanics methods for prolyl-leucyl-glycinamide (PLG) and structural analogsJournal of Molecular Structure: THEOCHEM, Volume 944, Issues 1-3, 30 March 2010, Pages 76-82 (doi:10.1016/j.theochem.2009.12.026 )"SMALL MOLECULES USED IN TREATING NEUROPSYCHIATRIC DISORDERS"-patent pending.
  • Hunt Valley Bluebird Boxes, Inc.
    Bluebird Nest Monitor
    Hunt Valley Bluebird Boxes, Inc. Apr 2007 - May 2007
    Monitored Eastern Bluebird nest boxes
  • Duquesne University
    Visiting Scholar
    Duquesne University Aug 2005 - May 2007
    Calculation of free energies of binding of carbohydrates to proteins.Use of molecular dynamics simulations in the study of the mechanism of the action of proteins on carbohydrates. Use of principal component analysis (PCA) to simplify and reduce the amount of data, and to determine those residues necessary for the binding and recognition of carbohydrates to proteins.
  • Synvax, Inc.
    Computational Chemist
    Synvax, Inc. Feb 2004 - Sep 2004
    Design of potential anticancer and antibiotic drugs and the writing of grant proposals to fund such projects.Presentations:Conformational Analysis of Hexapeptides with High Affinity Binding to ORL1 Receptor, R. L. Wood, D. J. Tuttle, R. W. Jones and A. K. Judd, at the Joint 59th Northwest and 18th Rocky Mountain American Chemical Society Regional Meeting in Logan, UT, June 2004.
  • Trinity University
    Post-Doctoral Associate
    Trinity University Oct 2002 - Jul 2003
    Quantum mechanical geometry optimizations of peptide nucleic acids (PNAs) as a function of chain length and base type (purine, pyrimidine or both).
  • Cornell University
    Post-Doctoral Associate
    Cornell University Sep 2000 - Sep 2002
    Use of molecular dynamics simulations to understand the role of the linker peptide of the endoglucanase CBHI during the process of the hydrolysis of cellulose by CBHI.Presentations:Molecular Modeling of Cellulose Hydrolysis, T. Rignall, C. McCabe, C. Skopec, R. L. Wood, J. W. Brady, and M. E. Himmel, at the Foundations of Molecular Modeling and Simulation, Keystone Resort, Keystone, CO, July 2003.Molecular Modeling of the T. reesei CBH I linker, T. Rignall, C. McCabe, R. L. Wood, J. W. Brady, and M. E. Himmel, at the 25th Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, CO, May 2003.
  • University Of Illinois At Chicago
    Graduate Assistant
    University Of Illinois At Chicago 1995 - 2000
    Molecular dynamics simulations of monolayers of saturated and unsaturated phospholipids, as well as analysis of the trajectories.Presentations:Molecular Dynamics Simulations of the Structural and Dynamic Effects of Double Bonds in Dimyristoyl Phosphatidylcholine and its Monolayers, American Chemical Society's 219th National Meeting in San Francisco, CA, March 2000.
  • Syracuse University
    Research Assistant
    Syracuse University 1984 - 1987
    Measurement and interpretation of the vibrational circular dichroism (VCD) spectra of small chiral organic molecules in solution.

Richard Leo Wood, Ph.D. Skills

Molecular Modeling Computational Chemistry Drug Design Chemistry Molecular Dynamics Medicinal Chemistry Protein Chemistry Drug Discovery Cheminformatics Docking Bioinformatics Drug Development Physical Chemistry Computational Biology Data Analysis Homology Modeling Quantum Chemistry Fortran Spectroscopy Statistics Statistical Mechanics Qsar Modeling Public Speaking Scientific Writing Theory Customer Service Spectrophotometry Uv/vis Gpcrs Mechanics Vmd Technical Writing Ir Spectroscopy Ligand Binding Virtual Screening Ir Teaching Ligand Based Design Gaussian Prediction Molecular Mechanics System Administration Property Prediction Grant Writing Computer Aided Drug Design Pharmaceuticals Mentoring Structure Based Design Technical Editing

Richard Leo Wood, Ph.D. Education Details

  • University Of Illinois At Chicago
    University Of Illinois At Chicago
    Computational Chemistry
  • Syracuse University
    Physical Chemistry
  • University Of Southern Maine
    University Of Southern Maine
    Chemistry

Frequently Asked Questions about Richard Leo Wood, Ph.D.

What company does Richard Leo Wood, Ph.D. work for?

Richard Leo Wood, Ph.D. works for Prairie State College

What is Richard Leo Wood, Ph.D.'s role at the current company?

Richard Leo Wood, Ph.D.'s current role is Adjunct Professor.

What is Richard Leo Wood, Ph.D.'s email address?

Richard Leo Wood, Ph.D.'s email address is rw****@****msn.com

What is Richard Leo Wood, Ph.D.'s direct phone number?

Richard Leo Wood, Ph.D.'s direct phone number is +143522*****

What schools did Richard Leo Wood, Ph.D. attend?

Richard Leo Wood, Ph.D. attended University Of Illinois At Chicago, Syracuse University, University Of Southern Maine.

What are some of Richard Leo Wood, Ph.D.'s interests?

Richard Leo Wood, Ph.D. has interest in Drug Design, Birding, Sports, The Beatles, Health, Ligand Protein Interactions, Education, Environment, Science And Technology, Human Rights.

What skills is Richard Leo Wood, Ph.D. known for?

Richard Leo Wood, Ph.D. has skills like Molecular Modeling, Computational Chemistry, Drug Design, Chemistry, Molecular Dynamics, Medicinal Chemistry, Protein Chemistry, Drug Discovery, Cheminformatics, Docking, Bioinformatics, Drug Development.

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