Richard Mazzarella Email & Phone Number

Bioinformatics And Computational Biology Program

Chemistry and Computational Biology of the Stem Cell NicheUK Regenerative Medicine Platform (UKRMP)

Saint Louis, MO

• NGS (next generation sequencing) analysis
• Whole genome sequence analysis
• Exome sequence analysis
• RNA-Seq analysis
• De novo genome assembly
• SNP, SNV and indel detection

• 2008 Pfizer Indications Discovery Delivery on Goals Award
• Data Mining of Diverse Data Sources for Hypothesis Generation
• Focus on Diabetes, Inflammatory Bowel Disease and Cancer
• Secondary Focus on other Inflammatory Diseases
• Coordination of All Genetic Analysis Information
• Four-time recipient of the Individual Performance Award

• Recipient of the Individual Performance Award
• Study of Angiogenesis and Cancer Therapeutic Targets
• Study of Osteoarthritis Targets
• Study of Hypertension & Syndrome X/Metabolic Syndrome
• Identification of colon cancer antibody targets (resulted in a Patent, a Drug Candidate Project and a Phase I Drug Trial)
• Identification osteoarthritis candidate genes (resulted in a Phase II OA Pain Drug Trial and a Phase I General Pain Trial)

• Searle Division of Monsanto
• Focused on the possible therapeutic targets of Cancer
• Analysis of large amounts of cDNA sequence information from murine and cell model systems
• Text mining of literature information
• Analysis of biological pathway information
• Prediction of the cellular function of unknown disease candidate genes

• Institute for Biomedical Computing and Center for Genetics in Medicine
• Identification and Analysis of Human Disease Loci
• Assembly and Analysis of Human Genomic Sequence
• Gene Prediction and Prediction of Protein Function and Subcellular Localization
• Determination of the molecular genetic basis for many human diseases
• CpG island analysis

• Microbiology and Center for Genetics in Medicine
• Early Member of the Human Genome Project (HGP) and a member of the Group that Assembled Map of Entire Human X Chromosome
• PNAS paper sponsored by Nobel laureate Jim Watson
• Isolation of very high molecular weight genomic DNA
• Construction of genomic yeast artificial chromosome (YAC) libraries
• Polymerase chain reaction application

• Study of Lymphocyte Differentiation
• Study of ER Biogenesis
• Study of ER Protein Sorting
• Strong Immunology, Biochemistry and Molecular Biology Training
• Plaque, RIA and ELISA assays
• Subcellular fractionation of organelles by sucrose gradients

Doctor Of Philosophy (Ph.D.), Microbiology

Bachelor Of Science (B.S.), Biology, Cum Laude

Activities and Societies: Microbiology Teaching Assistant

Education record