Riyaz Mohamed Email & Phone Number

Augusta, Georgia, United States

Augusta, Georgia Area

Role of Hypertension and sex on Acute kidney injury (AKI) to chronic kidney disease (CKD) progression in a different rodent models using cellular, molecular and pharmacological approaches.

Augusta, Georgia Area

Augusta, Georgia Area

• Showed hyperhomocysteinemia alters retinal endothelial cell barrier function and angiogenic potential via activation of oxidative stress
• Identified hyperhomocysteinemia induced choroidal neovascularization and function with features of age-related macular degeneration
• Identified Hyperhomocysteinemia activate NMDAr in retinal cells (endothelial, RPE and choroidal endothelial cells) to alter barrier function.
• Created endothelial specific NMDA receptor (Grin-1) Knockout animals to study underlying mechanism of homocysteine-induced diabetic retinopathy and age-related macular degeneration.
• Presented research findings in local and national scientific meetings.
• Showed diabetes induces imbalance of pro-neurotrophins /mature neurotrophins leads to up-regulation of the p75NTR receptor-induced cell death pathway.

Augusta, Georgia Area

• Utilized novel animal models to study the pathophysiology of acute and chronic kidney diseases.
• Identified Netrin-1 and semaphorin 3A as an early diagnostic biomarker for acute and chronic kidney diseases in animals and human.
• Standardized and established renal pedicle clamping surgery to induced clinically relevant acute kidney injury in animals.
• Explored the role and regulation of netrin-1 and semaphorin 3A in acute and chronic kidney diseases by utilizing genetically, pharmacological and cell-based approaches.
• Created specific RAG-1-Knockout mice, which have small lymphoid organs that do not contain mature B and T lymphocytes as a model to study the direct action of netrin-1 on neutrophils and monocytes in acute kidney injury.
• First one to identify a novel anti-inflammatory protein activated microglia/macrophage WAP domain protein (AMWAP) as the mediator of Histone deacetylases-elicited renal protection in cisplatin nephropathy.

Department Of Biochemistry, Mysore

I taught a semester-long course entitled Biochemical techniques, clinical biochemistry, enzymology and metabolism that was required for first and second-year undergraduate and master students. As a particle lab in charge, I was responsible for designing the content, presenting lectures, assessing student progress in classroom and laboratory components..

Bangalore

After my master graduation, I worked as a scientist in Integrated Drug Discovery group in pharmaceutical company Jubilant Biosys Ltd, India. Jubilant Biosys Ltd is part of the Jubilant Life Sciences providing innovative drug discovery services to the global pharmaceutical industry through its locations across India and the USA. Our discovery team focused.

Doctor Of Philosophy (Phd), Biochemistry

Activities and Societies: Project Title: “Synthesis and evaluation of therapeutically important Phospholipase A2 Inhibitors with.

Master'S Degree, Biochemistry, A+

Activities and Societies: Protect tittle “Partial purification of secretory phospholipase A2 (sPLA2) from Indian cobra (Naja naja) venom.

Bachelor'S Degree, Biochemistry, A