Robert Cavanagh Email & Phone Number

Nottingham, England, United Kingdom

Lead by Professor Cameron Alexander – Innovate UK Fellowship• Investigating therapeutic RNA delivery using polymeric/supramolecular systems for triple negative breast cancer• Screening of transfection efficacy and toxicity parameters in vitro using 2D and 3D cell culture models• Imaging delivery system internalisation and transfection using time-lapse high content confocal microscopy• Collaboration with industrial partners Aqdot (Cambridge, UK) and Centillion Technology Ltd… Show more Lead by Professor Cameron Alexander – Innovate UK Fellowship• Investigating therapeutic RNA delivery using polymeric/supramolecular systems for triple negative breast cancer• Screening of transfection efficacy and toxicity parameters in vitro using 2D and 3D cell culture models• Imaging delivery system internalisation and transfection using time-lapse high content confocal microscopy• Collaboration with industrial partners Aqdot (Cambridge, UK) and Centillion Technology Ltd (Cambridge, UK) Show less

Nottingham, England, United Kingdom

Lead by Professor Ruman Rahman - EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers• Investigated supramolecular hydrogels as implantable drug-delivery vehicles for post-surgical treatment of IDH1 wild-type glioblastoma.• Identification and optimisation of synergistic drug combinations and nanoparticle cargo for hydrogel loading.• Generation of 2D and 3D spheroid models of patient-derived glioblastoma cell lines for use in chemotherapy drug screening (mono- and multi-drug… Show more Lead by Professor Ruman Rahman - EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers• Investigated supramolecular hydrogels as implantable drug-delivery vehicles for post-surgical treatment of IDH1 wild-type glioblastoma.• Identification and optimisation of synergistic drug combinations and nanoparticle cargo for hydrogel loading.• Generation of 2D and 3D spheroid models of patient-derived glioblastoma cell lines for use in chemotherapy drug screening (mono- and multi-drug therapy), in vitro hydrogel cytotoxicity testing and studying internalisation mechanisms of polymeric nanoparticles.• Focus on distinct cellular responses of glioblastoma cells derived from tumour core and 5-ALA identified invasive margin cells.• Collaboration with Professors Cameron Alexander (University of Nottingham) and Oren Scherman (University of Cambridge) for expertise on polymeric nanoparticles and supramolecular hydrogel material, respectively. Show less

Nottingham, England, United Kingdom

Lead by Professor Cameron Alexander - EPSRC Impact fellowship• Studied the in vitro effects of ROS-responsive polymeric nanoparticles for the treatment of triple negative breast cancer.• Generation of a range of 2D and 3D culture models of luminal and triple negative breast cancer cell lines for investigation of drug and nanoparticle-drug potency, and nanoparticle endocytosis.• Developed in vitro methods for investigation and optimisation of synergistic drug combinations

Doctor Of Philosophy - Phd, Pharmaceutical Sciences

Thesis title: An investigation into mechanisms of non-ionic surfactant effect on epithelial cells PhD supervisor: Professor Snow Stolnik •.

Msc, Pharmacology

MSc research project - Investigating the expression of PPARγ in human chondrosarcoma and articular chondrocytes • Developed skills.

Bsc, Pharmacology

BSc research project - Investigating the functional importance of the kink in the helix of the GLP-1 ligand • Developed skills in cell.