Process Chemist for antibiotic drug development

Process chemist

Process chemist

Research Advisor: Professor James P. MorkenDevelopment of novel nickel-catalyzed 1,4-hydroboration and diboration of 1,3-dienes, to generate synthetically useful (Z)-allylic boronate esters, and application to the total synthesis of (+)-discodermolide.Publications:• Ely, R. J.; Yu, Z.; Morken, J. P. “Diastereoselective Ni-Catalyzed 1,4-Hydroboration of 1,3-Dieneols: Access to Synthetically Useful (Z)-Allyboronic Esters and Derived Polypropionate Motifs.” Tetrahedron Lett. 2015, 23, 3402. • Yu, Z; Ely, R. J.; Morken, J. P. “Synthesis of (+)-Discodermolide by Catalytic Stereoselective Borylation Reactions.” Angew. Chem. Int. Ed. 2014, 53, 9632.• Ely, R. J.; Morken, J. P. “Regio- and Stereoselective Ni-Catalyzed 1,4-Hydroboration of 1,3-Dienes: Access to Stereodefined (Z)-Allylboron Reagents and Derived Allylic Alcohols.” Org. Synth. 2011, 88, 342.• Ely, R. J.; Morken, J. P. “Ni(0)-Catalyzed 1,4-Selective Diboration of Conjugated Dienes.” Org. Lett. 2010, 12, 4348.• Ely, R. J.; Morken, J. P. “Regio- and Stereoselective Ni-Catalyzed 1,4-Hydroboration of 1,3-Dienes: Access to Stereodefined (Z)-Allylboron Reagents and Derived Allylic Alcohols.” J. Am. Chem. Soc. 2010, 132, 2534.

Medicinal Chemist Intern: Synthesis of a variety of small molecule kinase inhibitors for drug discovery, scale-up of advanced intermediates.Publications:• Ren, L.; Wenglowsky, S.; Miknis, G.; Rast, B.; Buckmelter, A. J.; Ely, R. J.; Schlachter, S.; Laird, E. R.; Randolph, N.; Callejo, M.; Martinson, M.; Galbraith, S.; Brandhuber, B. J.; Vigers, G.; Morales, T.; Voegtli, W. C.; Lyssikatos, J. “Non-oxime inhibitors of B-RafV600E kinase.” Bioorg. Med. Chem. Lett. 2011, 21, 1243.

Research Advisor: Professor Christopher N. BowmanSynthesis of novel thiol-ene monomers for dental restorative material application.Publications:• Carioscia, J. A.; Schneidewind, L.; O’Brien, C.; Ely, R. J.; Feeser, C.; Cramer, N.; Bowman, C. N. “Thiol–Norbornene Materials: Approaches to Develop High Tg Thiol–Ene Polymers.” J. Poly. M. Sci. Part A: Polym. Chem. 2007, 45, 5686.