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Robert Huether Email & Phone Number
Director Variant Science
at
Tempus, Inc.
1 work email found
@tempus.com
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✓ Verified Jul 2026
4 data sources
Profile completeness 86%
Current company
Role
Director Variant Science
Location
Greater Chicago Area, United States
Who is Robert Huether? Overview
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Robert Huether is listed as Director Variant Science at Tempus, Inc., based in Greater Chicago Area, United States. AeroLeads shows a work email signal at tempus.com and a matched LinkedIn profile for Robert Huether.
Robert Huether previously worked as Lead Clinical Scientist at Tempus, Inc. and Senior Computational Biologist at Tempus, Inc.. Robert Huether holds Ph.D., Structural Biology from University At Buffalo.
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{first}.{last}@tempus.com
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Profile bio
About Robert Huether
As a leader in cancer biology with a strong computational and experimental biology background, I have dedicated my career to combining macromolecular structural analysis with population genetics to understand the functional impact of variants in somatic cancers and rare diseases. My teams have successfully integrated genomic, structural, and functional data to prioritize, interpret, and classify the impact of variants derived from both somatic and germline sequencing. My ultimate goal is to generate prognostic, diagnostic, and therapeutic markers for clinical care.Key Capabilities • Developed strategy and overseen the development of genomics-based computational and machine learning tools for clinical markets, including somatic and germline variant prioritization methods, PGx algorithms, and literature prioritization using natural language processing.• Design, develop and apply pipelines on genetics, transcriptomic and reference sets for clinical molecular diagnostic applications.• Ensured the delivery of high-quality products within committed timelines.• Built and led teams of scientists, engineers, and analysts in computational efforts, fostering productive research collaborations• Proficient in drafting experimental plans, validation reports, work instructions, technology transfer documents, study summaries, and SOPs.• Strong record of developing and publishing computational analyses focused on human disease.I am proud to be a member of several expert panel working groups for the Clingen consortium, where we work towards setting gene-specific criteria for the analysis and classification of clinically relevant variants. Furthermore, my contributions in the field have been recognized, and I have been honored as one of Chicago's 40 under 40 Scientists. For more information, please visit my website: https://sites.google.com/site/rphuether/About
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8 roles · 24 years
Robert Huether work experience
A career timeline built from the work history available for this profile.
Director Variant Science
Current• Lead a cross-functional Translational Team to drive a development strategy that includes selection of computational and machine learning tools to identify biomarkers based on a deep biological understanding of mechanisms of action and a disease/disorder progression within oncology and hereditary (oncology and neurological) diseases.• Undertake a cross-functional engagement within Clinical Science, Clinical Operations and Research and Development for implementation of biomarkers on the clinical report.• Lead development of translation related sections in regulatory documents.• Participate in reviews and provide recommendations for business development opportunities.• Mentor junior members of the department and assist their work in translation strategy development and deployment.Highlights: Lead the research group to validated the DPYD/UGT1A1 algorithm for clinical reporting on chemotherapeutic adverse events.Lead early research and reporting logic of the a cell free assay
2019 - Present
~7 yrs 6 mos
Lead Clinical Scientist
Jan 2018 - Mar 2019
Senior Computational Biologist
Jan 2017 - Jan 2018
Computational Structural Biologist
Led a group of scientists in combining macromolecular structural analysis, population genetics, and next generation sequencing to understand and classify the functional impact of variants in Mendelian diseases. Collaborated and provided support for Reporting, Exome and Research Teams.Designed, implemented and applied high throughput structural analysis and machine learning methods to classify clinically identified variants.
Jul 2014 - Dec 2016
Postdoctoral Fellow In Computational And Structural Biology
Designed and analyzed a next generation sequencing (NGS) capture study of 1000 paired samples from 21 pediatric cancers based on 633 genes that influence the epigenome. Advanced computational tools used across St. Jude’s to relate cancer associated variants to their function, pathway, and structural alteration.Developed a structure based computational pipeline for analysis of the functional impact of NGS identified mutations.Identified and modeled novel loss-of-function mutations in the deubiquitinase USP7, a novel therapeutic target in T- cell Acute Lymphoblastic Leukemia.
2011 - Jul 2014
Structural Biology, Suny At Buffalo
Developed bioinformatic methodologies to identify and partition 19,000 enzymes of the short-chain oxidoreductase family into substrate specific groups.Identified and structurally characterized three new oxidoreductase enzymes.Developed a web-based interface for analysis and grouping of short-chain oxidoreductase substrate families by substrate fingerprints. http://labs.hwi.buffalo.edu/duax/phpmysql_webapplications/scor_copy/Contributed structural insights to the understanding of drug targetable Cysteine residues in the Breast Cancer protein 3β-hydroxysteroid dehydrogenase type 1.
Sep 2005 - Jul 2011
Research Associate
Characterize microbial and eukaryotic enzymes of the short-chain oxidoreductase family by substrate binding loops.Structurally modeled deleterious mutations in enzymes of the Rossman Fold family.
2003 - 2005
~2 yrs
3 education records
Robert Huether education
Ph.D., Structural Biology
M.A., Biology
B.S., Biology
FAQ
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What company does Robert Huether work for?
Robert Huether works for Tempus, Inc..
What is Robert Huether's role at Tempus, Inc.?
Robert Huether is listed as Director Variant Science at Tempus, Inc..
What is Robert Huether's email address?
AeroLeads has found 1 work email signal at @tempus.com for Robert Huether at Tempus, Inc..
Where is Robert Huether based?
Robert Huether is based in Greater Chicago Area, United States while working with Tempus, Inc..
What companies has Robert Huether worked for?
Robert Huether has worked for Tempus, Inc., Ambry Genetics, St. Jude Children'S Research Hospital, and Hauptman-Woodward Medical Research Institute.
How can I contact Robert Huether?
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What schools did Robert Huether attend?
Robert Huether holds Ph.D., Structural Biology from University At Buffalo.
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