Project representative with extensive knowledge in drug metabolism, PBPK modeling, and PK/PD modeling. Supervisor and mentor to a project representative and a QSP modeler.

Performed experiments to determine potential drug metabolism related liabilities including CYP induction (activity, mRNA, and protein levels), CYP inhibition (reversible and time dependent), metabolic stability, metabolite identification (in vitro and ex vivo samples including plasma and urine), reaction phenotyping (Phase 1 and Phase 2)Performed LC/MS method development for drug metabolism assaysCollaborate with Toxicology group in developing in vitro toxicology assays for identifying different types of hepatoxicity including phospholipidosis and steatosisPresent data at project team meetingsDraft protocols and study reports including those for IND submission