Robert Ziegler Email & Phone Number

Cambridge, Cambridgeshire, Gb

Lead chemist

Cambridge, Cambridgeshire, Gb

• Medicinal Chemist with experience working on a variety of oncology programs and targets, including: HPK1 inhibitor for immuno-oncology, epigenetic protein degrader (PROTAC), TEAD central pocket inhibitors, methyltransferase, and a phosphatase• Synthesis and design of selective and highly active molecules using structure-based drug design to deliver in vivo probe compounds to achieve lead optimization milestone• Involved in new target selection process by performing chemistry tractability assessments• Management of target compounds and intermediates synthesized at external CRO partners• Project chemistry leader for a hit to lead project

Cambridge, Ma, Us

• Postdoctoral associate in the laboratory of Professor Tim Jamison• Research focused on reducing the cost of anti-HIV active pharmaceutical ingredients (APIs) through the use of continuous flow chemistry to streamline and increase throughput• Completed the flow synthesis of dolutegravir in collaboration with the Roper group at VCU

Boston, Ma, Us

• Ph.D. student in the laboratory of Professor John Porco • Research focused on total synthesis of vinylallene antitumor natural products from Pestalotiopsis fici and enantioselective methodology development to synthesize new pyrone-substituted nitrogen heterocycles that resulted in a synthesis of pleiomaltinine• Developed a highly enantioselective addition of indoles to pyrones in collaboration with the Jacobsen group at Harvard

New York, New York, Us

• Continued work from the previous summer (June-August 2009)

Williamsburg, Va, Us

• Senior Thesis in Chemistry• Continued research started in summer 2008 (June-August)

Doctor Of Philosophy (Ph.D.), Synthetic Organic Chemistry

Bs, Chemistry

Math & Chemistry