Robert Marc Email & Phone Number

My global objectives are the development of imaging strategies and molecular probes designed to reveal cellular physiological states and large-scale neural systems reconstruction. The current focus is computational molecular phenotyping: a system of analysis based on anti-hapten molecular detection, high-density sample array fabrication, multidimensional image processing and computational pattern recognition analyses for image segmentation. I have developed a library of >60 small-molecule probes (including probes to the free states of 20 natural amino acids as well as glutathione, taurine, etc; and a set of exogenous probe molecules) to map cellular metabolic signatures, transport and channel permeation. The latter employs organic cation probes and detection to map functional glutamate signaling in the retina and brain. Applications of this technology include high-throughput phenotyping, pharmacological response assays, and cellular metabolic profiling. We have also discovered unprecedented plasticity and rewiring in the neural retina in advanced degenerative diseases; phenomena that change strategies for retinal rescue via genetic, molecular, cellular or bionic means. I have also founded a startup company, Signature Immunologics Inc, that provides a library of small molecule probes and continues to explore strategies for commercialization of anti-hapten methods. Finally, we are undertaking the largest ultrastructural neural systems reconstruction yet attempted.Specialties: Neural remodeling in retinal degenerationsComprehensive molecular mapping of ganglion cellsEM-LM molecular mappingMetabolic mapping probesIon channel activity mappingFirst CMP of a disease processSignature Immunologics establishedComputational molecular phenotyping (CMP)Functional mapping of vertebrate cone mosaics

Listed skills include Life Sciences, Science, Neuroscience, Molecular Biology, and 23 others.