Robert (Bob) Hunter Email & Phone Number

Durham, North Carolina, United States

· Designing PROTACs (Proteolysis targeting chimeras) for use in agriculture as novel herbicides, fungicides and insecticides.· Direction of CRO-based chemistry teams for multiple research programs.

Birmingham, Alabama

Medicinal Chemistry• Design and Synthesis of intermediate and target compounds for pharmaceutical purposes.• Coordinate efforts of CRO chemists for multiple research programs

Birmingham, Alabama Area

Medicinal Chemistry• Design and Synthesis of intermediate and target compounds for pharmaceutical purposes.• Coordinate efforts of CRO chemists for multiple research programs

Raleigh-Durham, North Carolina Area

Occupational Testing Service• Supervisor for 16 technologists. Scheduled and directed GC/MS and LC/MS technologists. • Accountable for quantity and quality of specimens handled and test results.• Managed the performance and behavior of staff in a positive and effective manner.• Demonstrated a strong ability to identify, analyze, and solve problems; keeping management informed of emerging issues and concerns.• Initiated quality-control measures and monitors quality of work… Show more Occupational Testing Service• Supervisor for 16 technologists. Scheduled and directed GC/MS and LC/MS technologists. • Accountable for quantity and quality of specimens handled and test results.• Managed the performance and behavior of staff in a positive and effective manner.• Demonstrated a strong ability to identify, analyze, and solve problems; keeping management informed of emerging issues and concerns.• Initiated quality-control measures and monitors quality of work for adherence to laboratory standards. Show less

Raleigh-Durham, North Carolina Area

Enteroendocrine unit, • Lead chemist for the discovery of novel GLP-1 peptide agonists. Coordinated and directed chemists during optimization and target validation. Developed chemistry strategy resulting in the discovery of novel GLP-1 peptide agonists demonstrating robust activity in vivo and enhanced metabolic stability. • Developed chemistry strategy and discovered novel CCK-A receptor peptide agonists which demonstrated robust activity in vivo and enhanced metabolic stability. •… Show more Enteroendocrine unit, • Lead chemist for the discovery of novel GLP-1 peptide agonists. Coordinated and directed chemists during optimization and target validation. Developed chemistry strategy resulting in the discovery of novel GLP-1 peptide agonists demonstrating robust activity in vivo and enhanced metabolic stability. • Developed chemistry strategy and discovered novel CCK-A receptor peptide agonists which demonstrated robust activity in vivo and enhanced metabolic stability. • Assisted in establishment of the peptide synthesis group within the Enteroendocrine Discovery Performance Unit. The remit of this group was to establish peptide synthesis infrastructure and expertise in peptide design, screening and optimization.• Lead peptide chemist for the discovery of novel Ghrelin agonists.• Retrofitted and Repurposed infrequently used automated chromatography instruments to run ion exchange chromatography columns resulting in a faster throughput for the program team and saving the unit in excess of $150,000.00Metabolic Lead Discovery Team• Hit to Lead stage parallel synthesis for the design and synthesis of novel kinase inhibitors.• Developed chemistry strategy resulting in the discovery of isoquinolinyl pyridones as SGK1 inhibitors. Show less

Raleigh-Durham, North Carolina Area

Division of Medicinal Chemistry• Synthesized intermediate and target compounds as kinase inhibitors for pharmaceutical purposes.• Developed chemistry strategy resulting in the discovery of aza-stilbenes as potent and selective c-RAF inhibitors.• Developed key structure activity relationships in the discovery of the anti-cancer medication VOTRIENT (Pazopanib).• Established and directed Post Synthetic Purification Specialists (PSPs) as a highly effective protocol for the HPLC… Show more Division of Medicinal Chemistry• Synthesized intermediate and target compounds as kinase inhibitors for pharmaceutical purposes.• Developed chemistry strategy resulting in the discovery of aza-stilbenes as potent and selective c-RAF inhibitors.• Developed key structure activity relationships in the discovery of the anti-cancer medication VOTRIENT (Pazopanib).• Established and directed Post Synthetic Purification Specialists (PSPs) as a highly effective protocol for the HPLC purification of small molecules in a High Throughput Hit to Lead Parallel synthesis lab. Show less