Roberto Magliozzi, Ph.D. work email
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Roberto Magliozzi, Ph.D. personal email
I am a science-driven and results-oriented scientist with 10 years of research experience in the field of protein engineering, molecular and cancer biology. I am currently Research Scientist in the Technology Discovery team at Kymab, supporting the development of novel therapeutic antibodies to treat diseases with severe unmet medical need. I am focusing on the development of next generation of bispecific antibodies by integrating bioinformatics, pre-clinical datasets and Kymab IntelliSelect discovery platform.As Translational Scientist in BioMarin I supported the translation of scientific concepts into novel therapeutics approaches. I focussed on the identification of novel disease and pharmacodynamic biomarkers for neuromuscular diseases to obtain a better understanding the mechanisms underlying the disease and to assess the efficacy of novel therapeutic approaches. To achieve this goal I integrated genomic, transcriptomic and proteomic large datasets with pre-clinical data and data mining.At the Hubrecht Institute, one of the top biomedical research institutes in the field of Cancer Stem Cells, I developed high throughput proteomic screens to identify novel substrates of the E3 ubiquitin ligases, crucial enzymes for the maintenance of cell homeostasis and frequently mutated in multiple types of cancer. I also set up diverse in vivo and in vitro cell-based assays to characterize the molecular effects of the newly identified targets in cancer development. A number of identified substrates can represent potential drug targets for anti-cancer therapy.With my expertise in biomedical research, I am well-qualified to support the discovery and translation into clinic of innovative therapies for cancer and other life-threatening diseases.
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Director DiscoveryT-Therapeutics Ltd Jun 2023 - PresentCambridge, Gb -
Cheeky Scientist AssociateCheeky Scientist Aug 2014 - PresentUs -
Associate DirectorSanofi Sep 2022 - Jun 2023Paris, France, Fr -
Group Leader Antibody DiscoveryKymab Ltd Sep 2021 - Sep 2022
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Senior Research Scientist IKymab Ltd Jan 2021 - Sep 2021
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Research Scientist IiKymab Ltd Jul 2018 - Jan 2021
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Research Scientist IKymab Ltd Jul 2017 - Jul 2018
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ScientistBiomarin Pharmaceutical Inc. Mar 2016 - Mar 2017San Rafael, Ca, UsIdentification of biomarkers for Neuromuscular Diseases: - As a key member of the Translational Sciences team, responsible for analysis and biological interpretation of large data sets resulting from unbiased exploratory profiling of proteins and non-coding RNA from patient samples collected in clinical studies in Duchenne Muscular Dystrophy. Proficient in data analysis approaches and tools including Tibco Spotfire, Pathway Studio, Key Pathway Advisor, Metacore Pathway. Trained in GLP and GCLP regulations and familiar with routine discovery and bioanalytical methods in an innovative and fast-paced biotechnology company setting. -
Postdoctoral FellowHubrecht Institute, Developmental Biology And Stem Cell Research Jan 2014 - Feb 2016Utrecht, NlInvestigating the role of ubiquitin ligases as potential targets for anticancer therapy and drug discovery. Better understanding of the molecular processes and identification of the components involved in the degradation of key proteins with crucial roles in oncogenesis will lead to the development of mechanism-based therapeutic agents for cancer treatment. -
Phd StudentHubrecht Institute, Developmental Biology And Stem Cell Research Mar 2009 - Jan 2014Utrecht, NlThe main objective of my research is to investigate how aberrant degradation of fundamental cellular regulatory proteins by the ubiquitin-proteasome system (UPS) contributes to tumorigenesis. To achieve this goal, I have been performing high-throughput proteomic screenings aimed at the identification of substrates of E3 ubiquitin ligases, key components of the UPS, using affinity chromatography tools and advanced mass spectrometry technologies. Moreover, I have been employing biochemical and cellular biological methods to elucidate the molecular mechanisms by which deregulated protein degradation contributes to malignant transformation. -
Research FellowUniversity Of Rome Tor Vergata Apr 2008 - Feb 2009Rome, Latium, ItI studied in vivo and in vitro the role of the endonuclease SPO11 during the formation of the doulbe strand breaks (DSBs) in mouse spermatogenesis.Applying molecular and biochemical approaches I characterized diverse isoforms of SPO11 which are required for the catalytic process of the DSBs during the meiosis.
Roberto Magliozzi, Ph.D. Skills
Roberto Magliozzi, Ph.D. Education Details
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Utrecht UniversityOncology And Cancer Biology -
University Of Tor Vergata, Faculty Of Medicine, Department Of Cellular Biology And Public HealthMedical Biotechnology -
University Of Tor Vergata, Faculty Of BiologyBiotechnology
Frequently Asked Questions about Roberto Magliozzi, Ph.D.
What company does Roberto Magliozzi, Ph.D. work for?
Roberto Magliozzi, Ph.D. works for T-Therapeutics Ltd
What is Roberto Magliozzi, Ph.D.'s role at the current company?
Roberto Magliozzi, Ph.D.'s current role is Director TCR Discovery.
What is Roberto Magliozzi, Ph.D.'s email address?
Roberto Magliozzi, Ph.D.'s email address is r.****@****echt.eu
What schools did Roberto Magliozzi, Ph.D. attend?
Roberto Magliozzi, Ph.D. attended Utrecht University, University Of Tor Vergata, Faculty Of Medicine, Department Of Cellular Biology And Public Health, University Of Tor Vergata, Faculty Of Biology.
What are some of Roberto Magliozzi, Ph.D.'s interests?
Roberto Magliozzi, Ph.D. has interest in Social Services, Education, Environment, Animal Welfare, Health.
What skills is Roberto Magliozzi, Ph.D. known for?
Roberto Magliozzi, Ph.D. has skills like Western Blotting, Affinity Chromatography, Immunoprecipitation, Pcr, Sds Page, Molecular Cloning, Molecular Biology, Biochemistry, Proteomics, In Vitro, Mammalian Cell Culture, Immunofluorescence.
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