ProQR is developing therapeutic oligonucleotides for treatment of sever genetic disorders. I'm responsible for the (bio)analytics of the compound for Cystic Fibrosis.Responsibilities: • (Bio)analytics for QR-010, lead compound for cystic fibrosis• Method transfer and validation at CROs• Management of clinical study samples measurements QR-010 • Long term analytical method strategy planning• Part of CMC team for new leads

Research Scientist at Proteros Biostructures GmbH, Martinsried, GermanyProteros produces crystal grade proteins, solves protein-ligand X-ray structures, performs HTS screenings and preclinical drug discovery projects.Responsibilities: - Development of cellular assays for compound screening with special focus on epigenetic proteins. Assay technologies include ELISA, western blotting, Nanostring, FRET and luciferase binding and activity measurements and gene reporter assays. - Assays for quantification of binding, activity and kinetics of interactions with the use of primary material and nucleosomes as substrates. - Quality control and tech transfer of developed assays- Evaluation of targets for lead discovery projects on Alzheimer’s disease, PTSD, Oncology and autoimmune diseases. - Workgroup leadership and organization role; daily supervision, training and motivation of technicians. This position is part of the Marie Curie Initial training network: Eutrain (eutrain-network.eu). A European network for the training of early career researchers.

PhD candidate, Pediatric Immunology, University Medical Centre Utrecht, The NetherlandsElucidating the molecular mechanisms in the auto inflammatory disease Mevalonate Kinase Deficiency, an inborn error of the cholesterol biosynthesis route. Responsibilities: - Use of patient primary cells for flow cytometry, confocal microscopy, ELISA and cytokine multiplex experiments.- Investigation of small GTPase localization and activity in affected cells- Determination of mitochondrial metabolism and phenotype in disease model. - Supervision and training of three master students and one bachelor student.