Operational manager of all Dutch Bioinformatics activities related to the international ELIXIR research infrastructure for life science data, including project management for the Dutch commitments in international grants.

* Coordination of FAIR data implementation projects in The Life Sciences in The Netherlands

Coordinating the data programme for the Dutch Techcentre for Life Sciences (DTL): (1) Bring people from companies and academic research together into collaborations, working on common solutions together. (2) Make sure expertise in life science data (including data stewardship) is available for all life scientists in The Netherlands.

Coordinating collaboration between academic groups performing software development inside the NBIC BioAssist program. Leading a team that continues software development that was started in academic groups into broader applicable applications.

Providing guidance to a diverse group of professionals in the development of single-crystal X-ray diffraction systems.Responsibilities: Continued responsibilities as Applications software developer. Lead a development department numbering between 5 and 12 engineers. Represent R&D in the management team of the Delft location. Lead selected R&D projects. Be a partner in government subsidized collaborative scientific developments with universities and other companies. Maintain the departmental ISO 9001 documentation. Advise the local management on IT issues. Since April 2004: additional responsibilities as "Director of Life Science R&D": Inform the CEO and board of directors monthly of world wide progress in R&D inside the product line. Represent R&D in the global product line management team meetings for single crystal diffraction. Inspire an international team of software engineers in different locations. Make a yearly presentation to the scientific advisory board of the product line.Accomplishments:● Coordinated a transition towards a LEAN development style. ● Improved collaboration between development sites by installing a search engine and shared access to documents. ● Introduced a metric measuring effective hours of the team; achieving scores >45%, 2x the average in the literature. ● Recruited seven new team members (internationally) that brought new experience into the group. ● Created yearly budget of 1M€ including materials, depreciations, salaries and subsidies. ● Led the team that developed the most intense affordable and award winning X-ray source on the market. ● Instated a pro-active management style that was copied partly by others, inspiring team members and colleagues. ● Provided motivation to the development group through several company reorganizations. ● Minimized the budget required for IT through deployment of open-source services, e.g. for issue tracking.

Responsibilities: Set up application software for Nonius new line of CCD diffraction systems. Collaborated with Utrecht University to set up a contingency software project to prevent depending on package with a single (difficult) supplier. Provided customer support for difficult problems. Accomplishments: ● Wrote application software that is respected as the most easy to use software for single crystal diffraction to date. ● Was more productive than competition with 5x more programmers using efficient programming techniques. ● Protected a method by authoring a patent documenting an invention done in collaboration with Utrecht University. ● Demonstrated to customers that the company was a valuable scientific partner in demonstrations on shows. ● Developed groundbreaking new algorithms starting from knowledge from scientific papers only. ● Wrote a break-through scientific paper that resulted in invitations to speak at five international conferences. ● Designed the architecture of major software packages sold with Bruker AXS Single Crystal instruments.

Responsibilities: Write verification tools for protein structures, these tools are included into the WHAT IF program. Collaborate on other aspects of the molecular modeling software WHAT IF, including the 3D graphics engines, the user interface and the documentation. Accomplishments:● Made protein modeling easier by creating databases of protein structural features and protein structure quality. ● Warned other scientists for the importance of quality checks by presenting results in Nature, cited 950 times. ● Kept other scientists informed by presenting results at several international scientific conferences. ● Achieved recognition by writing 4 scientific articles (as first author) describing newly developed methods. ● Helped crystallographers test the quality of their results by building a web service with the software.

Research the structure/activity relationships of sweet tasting compounds.Accomplishments:● Developed new (parallelized) software for modelling flexible molecules using molecular mechanics.● Developed new software for modelling flexible molecules using molecular dynamics.● Wrote a chapter in a book on sweet taste chemoreception.● Solved a number of small molecule organic crystal structures.