Rohitash Jamwal Email & Phone Number

Glastonbury, Ct, Us

Cambridge, Massachusetts, Us

DMPK project representative for discovery through development programs across small molecules and protein degraders.- Early discovery strategy for ADME/DMPK studies- IVIVC, modelling and simulation (NCA, PK/PD), DDI risk assessment- Human PK and efficacious dose projection

Cambridge, Ma, Us

Discovery DMPK project lead - supported nomination of two development candidates - authored reports for IND submission.

Cambridge, Ma, Us

- Discovery DMPK project lead responsible for operational and technical oversight of DMPK activities at CROs and external partners- Executed strategies to advance hit-to-lead and lead optimization programs through development candidate (DC) selection- Designed and directed internal and external DMPK activities (in vitro, in vivo, PK, PK/PD, TK), including routine studies, troubleshooting, and issue management- Analyzed experimental data and communicated results through oral presentations/written documents to other DMPK colleagues and multidisciplinary project teams- Human PK parameter and dose predictions- Collaborated with toxicology and CMC teams to enable formulation selection and de-risking strategies in tox studies- Contributed to DMPK sections of regulatory documents (DC, IB, IND) as needed

Cambridge, Ma, Us

- Conducted need-based bioanalytical method development/optimization/qualification to support drug/metabolites (PK) and biomarker (PD) analysis for clinical programs- Qualified a micro-sampling based bioanalytical method for quantification of a leading molecule in human whole blood- Investigated issue-driven bioanalytical questions for various development projects- Hands-on experience with Watson LIMS, Waters, and SCIEX LC-MS/MS systems (Xevo TQ-MS, SCIEX 4000, 5600, 6500, 7500)- Managed requalification for reference analytical standards being used by CROs- Was responsible for managing DevBA reports and documents on Veeva, a cloud-based document management system- Supported cross-functional bioanalytical needs for discovery projects as and when needed

South San Francisco, Ca, Us

Cross-functional DMPK project representative on "organ-selective" discovery projects in respiratory programs

Kingston, Ri, Us

• Worked on a collaborative project to develop a drug for alcohol use disorder.• Developed LC-MS/MS based assay for quantification of protein expression of aldehyde oxidase in a human liver-bank (n=90).• Studied the variability in the functional activity of aldehyde oxidase in a large human liver-bank (n=90)

Kingston, Ri, Us

• Studied the effect of non-alcoholic fatty liver disease (NAFLD) on drug metabolizing enzymes, with emphasis on cytochrome P450 enzymes (CYPs). • Developed "fit-for-purpose" methods for quantification of proteins in different matrices and fractions (plasma, tissue, cells) • Developed and validated an LC-MS/MS (RPLC) based method for quantification of cannabinoids in human plasma• Trained graduate students on the various shotgun proteomics and bioanalysis workflows

Kingston, Ri, Us

• Integrated Patient Simulation (Spring 2015-18) : Assisted in running Patient Simulation Lab and ran disease simulations on different simulators for PharmD, BSPS, Kinesiology and Physical Therapy students. • Drug Metabolism (Spring 2017): General teaching assistant with the course.• Advanced Pharmacokinetics (Spring 2016): Assisted in advanced course with setting up Simcyp and basic use of the software for PBPK analysis.• Pharmacy Compounding (Fall 2014): Demonstrated different drug compounding techniques and assisted students to compound different drug formulations.

Rahway, New Jersey, Us

Examined the performance of various static basic and mechanistic models to predict drug-drug interaction (DDI) for ~50 Merck compounds that had clinical data available

Emeryville, Ca, Us

Developed and implemented a straightforward and cost-effective dimethyl labeling-based multiplex method for proteomic analysis, which reduced the sample analysis time by 3X.

Bangalore, Karnataka, In

• Served as a cross-functional ADME and Bioassay lead.• Co-ordinated and represented the early ADME department in various interdisciplinary projects.• Implemented LC-MS/MS-based assays in ADME to replace HPLC-based bioanalysis. • Established high-throughput bioassays to support screening of plants against new druggable targets. • Co-authored 6 peer-reviewed articles in reputed international journals. • Mentored 5 new employees and 10+ interns in research methodology and data analysis.

Ansari Nagar, New Delhi, In

Evaluated the in vitro herb-drug interactions between herbs and drugs used for the treatment of type 2 diabetes, rheumatoid arthritis, and epilepsy.

Kolkata, Westbengal, In

Studied plant extracts for their antibacterial activity against pathogenic species including Vibrio cholerae, Helicobacter pylori, Klebsiella pneumonia.

Doctor Of Philosophy (Phd), Pharmaceutical Sciences (Pharmacokinetics)

Master Of Technology, Biotechnology

Bachelor Of Technology, Biotechnology