Rohit R. Email & Phone Number

San Francisco Bay Area

Medicinal ChemistryIntegrin inhibitors for fibrotic diseasesHit to lead, lead optimization , macrocyclic drug design, structure based drug design, large dataset analysis, chemoinformaticsLab automation/liquid handling, chemical library generation,ADMET optimization

San Francisco Bay Area

Medicinal/Discovery Chemistry: Development of small molecule host-directed and direct-acting therapeutics for respiratory and inflammatory diseases. Pushing for creativity and chemical diversity.Breakthroughs in SAR, optimization of ADMET properties, Managing CRO's, Managing laboratory operations.Structure based, Ligand based, and Competitive intelligence based lead generation and optimization. Significant contributions to new project proposals, identification and evaluation of known chemical matter, Analysis of competitor molecules, identification of potential ADMET challenges. Analytical support; method development, troubleshooting, chiral screening, purification, HPLC, LC-MS; analytical and preparatory scale, NMR

South San Francisco, California

Small Molecule Process ChemistryDeveloped reaction methodology and optimizations on synthetic steps formultiple small molecules. Selective N-alkyl pyrazole synthesis, nitroso reduction, synthesis of substituted hydrazines, carbamate synthesis, Buchwald aminations, etc.Developed a critical last step crystallization controlling purity and crystal form, route incorporated into cGMP synthesis at 7 kilo scale and successfully transferred to pilot plant scale.Optimized synthesis of starting material for an API, improving yields, purity and transitioning to a greener solventDiscovered and eliminated key impurity previously unrecognized in startingmaterial by optimizing synthetic routeContractor through PPD

Petaluma, California

Synthesis of oligonucleotide phosphoramidite monomers and fluorescence quenchers.Contractor through Apex

Ann Arbor, Michigan

Investigated novel Palladium catalyzed alkene difunctionalization reactions with respect to the formation of substituted carbo/heterocycles in John Wolfe's Group.

San Diego, California

Synthesis and characterization of Cyclic Alkyl Amino Carbenes.At the Guy Bertrand lab.

San Diego, California

Explored the non-canonical activation pathways and functions of NF-kB. At the Gourisankar Ghosh lab.

Master Of Science - Ms, Chemistry

Bachelor Of Science - Bs, Molecular Synthesis