Rik Frank, Ph.D. Email & Phone Number

San Diego, CA, US

• I am responsible for driving discovery and pre-clinical research toward the development of antibody drug conjugates, bi-specific antibodies and engineered cytokines for immuno-oncology.Among my accomplishments, I have.
• In vitro cell-based and plate-based assays to evaluate receptor bias, T cell activation, cytokine induction and cytotoxicity of engineered cytokines and bispecific antibodies.
• Assays for binding, cytotoxicity Antibody-Dependent Cellular Cytotoxicity (ADCC) and other effector functions to support drug discovery and IND-enabling studies.Among my areas of proven performance with Ambrx, I:
• Create and formalize flow cytometry and other cell-based experiments to investigate the characteristics of drug candidates, with attention to immune response quality and effects on normal tissue.
• Draw upon my scientific specialty and problem solving skills to discover and present creative solutions which answer experimental questions.
• Often serve as Functional Lead in a matrixed R&D environment. Bear accountability as the voice of the project, representing the research progress of a core team of scientists toward the business.

Waltham, MA, US

• I progressed into an oversight role managing this company's custom products laboratory and a team of research associates. I was effectively retained after Thermo Fisher's acquisition of Affymetrix eBioscience.Among my.
• Coordinated a team of researchers as a trusted, quality-driven and knowledgeable leader, with accountability over timelines, resources, and priorities related to our collective success.
• Met the expectations of major pharmaceutical clients in the build and delivery of custom conjugates, antibody fragments, antibody cocktails, and immunoassays.

San Diego, CA, US

• I returned to this company 4 years after completing my Ph.D. to develop novel reagents and technologies. It was a rewarding and fulfilling experience to drive exploratory research and development of proprietary.
• Designed, developed optimized reagents and procedures to ensure the effectiveness of PrimeFlow RNA for use in lysed whole blood and other primary cells.
• Communicated scientific subject matter when training sales representatives, collaborators and field application scientists on the PrimeFlow RNA assay, creating clarity around its hands-on operation, design, and other.

Throughout my experience with this CRO, I gained valuable experience in a cGMP environment while developing chromatographic and immunological assays. Over the course of this two year-long tenure, I enhanced the operating environment through the establishment of operating procedures and qualification protocols, in addition to the design and implementation.

I capitalized on the opportunity to broaden my professional perspective in a role focused on managing a portfolio of antibody products, coupled with the development and refinement of R&D and production strategy. I was successful in interpreting insights from emerging scientific research to ensure the optimal progress and direction of product development.

Duarte, CA, US

I completed a dissertation entitled "Neural Stem Cells as a Novel Platform for Tumor-Specific Delivery of Therapeutic Antibodies". In the completion of my research, I investigated the feasibility of using tumor-tropic human neural stem cells to deliver trastuzumab (Herceptin) to malignant foci in vivo, including across the blood-brain barrier. The.

San Diego, CA, US

In my initial role with eBioscience, I held a substantial role in the planning, development and release of new monoclonal antibodies. I was directly involved in innovating novel and unprecedented antibodies and a buffer set instrumental to the successful detection of FoxP3 with flow cytometry.

Ph.D., Immunology / Immuno-Oncology

Certificate, Bioscience Management

Bs, Biology

Hs Diploma

Education record