• Provided organizational and scientific leadership in the DMPK and exploratory toxicology areas by outlining program strategy, experimental study designs, and workflow for reporting• Successfully managed lead program’s 28-day GLP IND-enabling toxicology studies including genetic toxicology and safety pharmacology studies• Built out laboratory to create and implement a formulation strategy to support preclinical and early clinical development of novel drug candidates• Developed and managed DMPK and exploratory toxicology groups, including management of budget, timelines, and goals• Established, supervised, and interpreted data from external contract research organizations (CROs) in support of in vivo/in vitro ADME studies, multi-day dose range finding studies, and safety pharmacology studies, including Ames, MNT, hERG, and DILI• Generated, interpreted, and applied pharmacokinetic/toxicokinetic parameters using WinNonlin to support candidate selection• Designed and conducted pre-formulation assessment studies (intravenous and orally administration) for in vivo pharmacokinetic, efficacy, and PK/PD studies

• Efficiently managed two 28-day GLP CTA-enabling toxicology studies• Authored all ADME and select toxicology reports for two CTA submissions to regulatory agencies• Built out DMPK laboratory to process bioanalytical samples, formulate test article, and perform in vitro ADME assessment studies• Led DMPK department supporting discovery and development efforts including management of staff, budget, goals, timelines, and team member’s development• Researched, managed, and interpreted data from external contract research organizations (CROs) in support of in vivo and in vitro pre-clinical studies including exploratory toxicology and safety pharmacology studies• Processed and analyzed in vitro ADME assays and in vivo samples in various matrices by LC-MS/MS• Determined pharmacokinetic/toxicokinetic parameters using WinNonlin from bioanalytical results to support candidate selection• Performed pre-formulation assessments of novel drug candidates for in vivo pharmacokinetic, efficacy, and PK/PD studies

• Successfully and effectively managed pharmacokinetic sample analysis at contract laboratory to ensure smooth progress and on time completion of interim data from phase I clinical study• Tested and implemented new software, MetaboLynx, to perform high throughput metabolite identification• Led Bioanalytical/Pharmacokinetic group supporting discovery and development efforts for small molecule kinase inhibitors• Performed bioanalytical method development, validation, sample preparation and analysis for clinical and pre-clinical pharmacokinetic studies• Executed in-vitro studies including metabolite identification, metabolic stability, plasma protein binding, protein stability, and non-specific binding studies• Researched, audited, negotiated, and managed bioanalytical contract research organization (CRO) in support of clinical and pre-clinical studies• Participated on multi-disciplinary project teams to trouble shoot, guide, and select lead candidates• Managed BA/PK group’s staff, goals, timelines, team member’s development, evaluation, and mentoring • Proven proficiency in data compilation, interpretation, and reporting results both in oral and written form• Presented data at biweekly meetings providing guidance and support to R&D efforts

• Facilitated the discovery of small molecule-protein binders using two high-throughput screening platforms (LC-MS) on a daily basis • Conducted advanced experiments to further optimize small molecule compounds including Kd determination and ligand-ligand competition experiments• Assisted group leader with managerial duties including experiment scheduling, process improvements, screening operations, training and advanced troubleshooting of ALIS (Automated Ligand Identification System) technology platform• Prepared and delivered biweekly presentations for upper-level management and fellow scientists regarding progress of campaigns, biochemistry of drug target, advanced experiment data results and comparative analysis of new competing high-throughput technologies

•Taught biology, chemistry, and general science to 120 students in Years 9–13 on a daily basis•Developed and implemented new science curriculum for all Year 9 classes•Collaborated with Samoan counterpart to plan lab experiments and lecture materials•Established teacher evaluations to improve quality of educational services