Synthesis and biological Evaluation of Benzimidiazoles; Towards a novel Therapy selectively Targeting C. neoformans β-tubulin. Synthesis of novel benzimidazoles derivatives for biological testing. Focus upon analogues of Flubendazole, identifying key medicinal chemistry changes to enhance activity. Discovery of large compounds library to develop SAR information.

Synthesis of Selective Small Molecule Inhibitors for Cyclophilin D, as a Treatment for Pancreatitis.Work developing small molecule inhibitors for Cyclophillin D target. Modelling, synthesis and biological testing of target inhibitors.Structure based design approach to optimise lead compound. Focused upon bioisosteric replacement, and enhancing metabolic stability.