Ryan Pearce Email & Phone Number
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Ryan Pearce is listed as Postdoctoral Researcher in Microbiology at University of Oxford, based in Greater Liverpool Area, United Kingdom. AeroLeads shows a matched LinkedIn profile for Ryan Pearce.
Ryan Pearce previously worked as Postdoctoral Research Associate at Liverpool School Of Tropical Medicine and Postdoctoral Research Associate at Liverpool School Of Tropical Medicine. Ryan Pearce holds Antimicrobial Resistance from Royal Veterinary College, U. Of London.
Email format at University of Oxford
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About Ryan Pearce
PhD, Department of Pathobiology and Population Sciences (PPS), Royal Veterinary College, London (UK) + Section of Veterinary Clinical Microbiology (VCM), University of Copenhagen, Copenhagen (Denmark) (April 2020- June 2024).• Experience in a broad range of molecular and biochemical techniques in general microbiology and hands on veterinary diagnostic procedures and testing.• Successful fulfilment of research objectives within project and grant timelines.• Development by validation of high-throughput (Fluidigm) qPCR assays for the detection of antimicrobial resistance genes. • Determination of the frequency which seafood products available at retail to consumers in the UK are contaminated with ESBL-producing bacteria and the specific ESBL type present using High-throughput qPCR (Fludigm). • Characterization of ESBL-producing gram-negative bacteria phenotypically via MIC determination using broth microdilution and typing via MALDI-TOF-MS.• Bioinformatic analyses of the most clinically significant isolates to elucidate; strain types, virulence, antimicrobial resistance genes. And, to understand if the resistance genes found are chromosomally or plasmid based.• Determination the frequency of bacteria carrying transmissible plasmids which can be transferred to human gut bacteria (E. coli). • Identification of plasmid types that carry CTX-M ESBL ARG’s on the transferred plasmids via PCR based replicon typing (PBRT) and characterization of transferrable plasmid sequences using long-read sequencing (nanopore). • Creation of a mobile colistin resistance gene database to aid in detection and characterization of novel determinants and potential progenitor sequences.• Establishment of the genomic basis of colistin resistance and providing a genetic and pathogenic characterization of our collection of putative colistin resistant isolates by whole-genome sequencing.• Identification and assessment of novel mobile colistin resistance genes through biochemical methods and bioinformatic analysis.• Analysis of mobile colistin resistance gene and protein expression development in mutant and wild-type bacteria.
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Ryan Pearce work experience
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Postdoctoral Research Associate
Postdoctoral Research Associate
Phd Researcher
• iCASE PhD - Microbiology (Bacteriology) - Investigation of Antimicrobial-resistant bacteria in seafood products and risk of exposure to these by consumers in the UK.o Objectives; 1) to elucidate the frequency of ESBL, carbapenamase and mcr -producing bacteria in aquaculture produced imported seafood products at a retail level in the UK. 2) Type the ESBL and carbapenamase variants and bacteria carrying these ARG’s from British seafood products. 3) Understand if these ESBL and carbapenamase… Show more • iCASE PhD - Microbiology (Bacteriology) - Investigation of Antimicrobial-resistant bacteria in seafood products and risk of exposure to these by consumers in the UK.o Objectives; 1) to elucidate the frequency of ESBL, carbapenamase and mcr -producing bacteria in aquaculture produced imported seafood products at a retail level in the UK. 2) Type the ESBL and carbapenamase variants and bacteria carrying these ARG’s from British seafood products. 3) Understand if these ESBL and carbapenamase ARG’s are carried on plasmids or the chromosome and if they are transferrable to human gut bacteria. 4) determine if GNB bacteria collected from retail British seafood products carry novel mcr genes. 5) Determine if genes detected in GNB from retail British seafood products are progenitor/ related sequences to any known mcr resistant genes or variants. 6) Use the data generated on the presence of new mcr resistant genes or presence of mcr-like sequences to propose a hypothesis of if British seafood products are a reservoir of bacteria carrying mcr resistant genes and if this could pose a potential risk to British consumers.• Key research: Understanding the frequency of resistance to ESBL and Carbapenamase in retail British seafood products, Elucidating the transferability of resistance genes from bacteria of seafood to human commensal/ potential pathogens, Understanding the origin of mobile colistin resistance and if seafood presents a novel reservoir. Show less
Phd Secondment - One Health Antimicrobial Resistance (Ohar) Group
Phd Secondment - Food Standards Agency
This secondment is based in a department focusing on quantitative risk assessment to characterise risk to the end consumer of products contaminated with bacterial agents.The work conducted here will inform on government policy on interventions to aid in better food safety.
Awarded: European Cooperation In Science And Technology Grant - Ca18217
Won a 2500€ grant to aid in completion of a project "Fluidgm multiplex qPCR detection of AMR genes of clinical and public health relevance" which directly aided in the validation of a public health/ veterinary diagnostic tool to characterise antimicrobial resistance genes of clinical relevance.
Ryan Pearce education
Antimicrobial Resistance
Master'S Degree, Molecular Microbiology, Merit
Education record
Frequently asked questions about Ryan Pearce
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What company does Ryan Pearce work for?
Ryan Pearce works for University of Oxford.
What is Ryan Pearce's role at University of Oxford?
Ryan Pearce is listed as Postdoctoral Researcher in Microbiology at University of Oxford.
Where is Ryan Pearce based?
Ryan Pearce is based in Greater Liverpool Area, United Kingdom while working with University of Oxford.
What companies has Ryan Pearce worked for?
Ryan Pearce has worked for University Of Oxford, Liverpool School Of Tropical Medicine, Royal Veterinary College, U. Of London, Københavns Universitet - University Of Copenhagen, and Food Standards Agency.
How can I contact Ryan Pearce?
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What schools did Ryan Pearce attend?
Ryan Pearce holds Antimicrobial Resistance from Royal Veterinary College, U. Of London.
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