Ryan Wong Email & Phone Number

Somerville, Massachusetts, United States

Cambridge, Massachusetts, United States

Led pilot lab activities and operations by scheduling pilot productions and coordinating cross-functional efforts to plan for future production runs. Sat on multiple CMC program task forces acting as the pilot SME providing technical and operational support to research and external manufacturers. Communicated extensively with vendors and external manufacturing to troubleshoot and resolve technical issues and consumable restrictions.• Organized and executed several successful pilot suspension LVV productions that were 100x routine bench-scale volume, the largest scale ever completed at 2seventy bio.• Delivered production runs 100% on schedule to ensure process delivery milestones were achieved.• Authored 20+ pilot-related documents including development batch records, work instructions, assembly drawings, protocols, and technical reports.

Cambridge, Massachusetts, United States

Spearheaded the setup and operational readiness of the pilot-scale manufacturing lab at 2seventy bio to begin productions for CMC and manufacturing support while simultaneously serving as manager for the small-scale manufacturing team. Represented 2seventy bio at external manufacturing sites for person-in-place (PIP) visits to observe and consult during suspension LVV manufacturing productions.• Led the assembly and creation of the pilot laboratory at 2seventy bio that would reduce engineering and pilot run costs by approximately $1.5M operating in-house instead of externally.• Maintained thriving relationships and open communication with 10+ vendors to secure vital processconsumables and equipment to meet fast-paced timelines.• Coordinated 50+ successful bench-scale production runs communicating cross-functionally with stakeholders to organize supporting development studies and analytical testing required.

Cambridge, Massachusetts, United States

Launched the kickoff initiative for the creation of the pilot-scale manufacturing lab at bluebird. Led a team of 8-10 individuals to meet a fast-paced timeline for pilot-lab readiness involving vendor communication for consumable ordering, scale-up studies, and updates to various pilot documents including SOPs, work instructions, and execution batch records. Organized documentation updates and formalization for pilot readiness while continuing the execution of weekly small-scale suspension LVV productions for various stakeholders.• Key contributor to the setup of the pilot lab machinery and equipment managing over $1M worth of purchases.• Coordinated 5S methodology initiatives in two separate lab spaces to further improve and optimize laboperations and functions.• Executed 50+ successful suspension LVV bench-scale productions upstream through downstream processing for R&D and CMC activities.

Cambridge, Massachusetts

Small-scale manufacturing scientist entrusted with the crucial responsibility of bringing the adherent manufacturing scale process in-house while consistently overseeing both adherent and suspension LVV production runs weekly to meet the demands of diverse stakeholders. Designed and executed small-scale development experiments related to validating various lots of raw materials, process optimization, and tech transfer of the suspension LVV process over to the small-scale manufacturing team. Managed lab consumable inventory and led all procurement activities and vendor communication. Trained and consulted external manufacturer personnel to execute the adherent LVV process at their facilities.• Successfully led and completed 10+ manufacturing-scale adherent LVV productions in-house resulting in 10x the stock of LVV for R&D studies and CMC activities.• Executed 200+ adherent and suspension LVV bench-scale productions from vial thaw through final LVV filtration for research and analytic development.

Cambridge, Massachusetts

Small-scale manufacturing scientist responsible for executing adherent LVV production runs on a weekly basis for various stakeholders within bluebird.• Executed 50+ adherent LVV bench-scale productions from cell passaging through final LVV filtration for research and analytic development.

Cambridge, Massachusetts

- Developed an AAV suspension process platform from bench top and shake-flask experiments to scale-up production in bioreactors- Analyzed cell culture samples and data to present at weekly meetings.- Wrote up standard operating procedures (SOP) and protocols for process platform- Kept detailed records of cell culture growth and activity using MS Excel

Cambridge, Massachusetts

- Ran fate-purge studies on segments of drug development processes to optimize purity- Characterized and helped to develop decolorization process to be used in drug development- Collaborated with other scientists to develop an automated pumping system incorporating LabVIEW- Experimented with DynoChem software to run process simulations

Lexington, Massachusetts

- Performed laboratory experiments to support process development activites- Participated in Design of Experiments (DOE) in order to optimize process parameters in drug development- Analyzed process samples using HPLC and trained new laboratory analyst on HPLC processes and maintenance including Empower analysis program

Upton, Ny

- Performed experiments to observe the impact of oscillating pH on nanocrystals and clusters- Functionalized gold nanoparticles for research conducted by coworkers and advisor- Developed system used to control and sustain an oscillating reaction

Bachelor Of Science (B.S.), Chemical Engineering W/ Minor In Biochemical Engineering

Activities and Societies: Northeastern University Symphony Orchestra, American Institute of Chemical Engineers, Omega Chi Epsilon Chemical.

Diploma W/ Advanced Designation And Honors

Activities and Societies: Science Olympiad team (Vice President 2010-2011), Chamber Orchestra (Principal violist), Varsity Tennis.