Stephane Chiron Email & Phone Number

Lyon, Fr

Mannheim, Bw, De

Paris, France, Fr

Global Regulatory Affairs Project Manager on COVID vaccine

Lyon, Auvergne-Rhône-Alpes, Fr

CMC: Chemistry, Manufacturing and ControlsSpecialized in Biologics.Project managementCollaboration with partners (CDMOs, CMOs and CROs)Analytical Sciences (Characterization and method Validation)CMC documentations (CTD/ICH module 3, URS, ...)Regulatory Compliance (GxPs, ICH, ...)» Project management with Clinical Department and Chief Operating Officer.» CMOs and CROs management.» Biological Drug Substances/Drug Products Characterizations.» Supply Management, Starting materials and consumables with CMOs.» Drug Substance and Drug Product production management.» Preparation of Process Validation as per GMP and ICH guidelines.» Development of New Analytical Methods.» Management of Method Validation by CRO as per ICH guidelines.» Management of Stability studies; planning, follow-up and reviews.» Regulatory documents management; Scientific Advices, URS, IMPD.

Plan-Les-Ouates, Geneva, Ch

CMC: Chemistry, Manufacturing and ControlsSpecialized in Biologics.

Paris, Île-De-France, Fr

Multiomics.High throughput microfluidics in Biology.Projects development; implication in a Proof of Concept grant from ERC and a funding from Bpifrance (PSPC) in collaboration with HiFiBiO.Projects management and co-management of researchers, postdocs and PhDs.Development of a process “femtoliter scale microfluidics” for in-vitro protein evolution, using in-vitro compartimentalized self-replication.Application of microfluidics to perform ELISA into nanoliter droplets, for secretion analysis.Development of CITE-Seq in conjunction to scRNA-Seq for immunity/cancer cell interactions.Development of new technologies and approaches for single cell analysis using NGS as readout.Analysis of Illumina sequencing (Big Data Analysis using R and Python).

Évry, Ile-De-France, Fr

Production of C3P3®; a high yield In Vitro Transcription systems for mRNA production.Project management, under supervision of the scientific director.Creation and structuration of the laboratory.Creation and Development of a new process to quantify the capping efficiency of RNAs.

Fontenay-Aux-Roses, Fr

Ionizing radiations on muscle and cell therapies approaches. Radio-pathology and Experimental Therapy Laboratory (LRTE). R. TamaratProject management and management of a research engineer.Identification of a long term muscular hypotrophy after irradiation.Characterization of muscle stem cell morbidity in vivo after irradiation.Small animal (mice) experimentsIrradiation experimentsFACS analysis and cell sortingMuscle stem cells isolation and culture

Set up and uses of 3D cell culture system for studies on myogenesis and mechanotransduction.Therapies of the disorders of striated muscle. C. CoiraultProject and team management, composed of two research engineers and a student.Creation of 3D culture of primary muscular human cells.Characterization of the differences in cellular adhesions between 3D and 2D cultures.Primary muscle cell cultureTridimensional (3D) cultureConfocal microscopy (Scanning)

La Jolla, Ca, Us

Transcriptional regulation of chromogranin A in neuroblastoma and pheochromocytoma cells.Chromaffin Cell and Hypertension Research Laboratory. D.T. O'ConnorProject development and management - co-management of two master students.Identification of the transcription factor modulating CHGA expression in hypertension.Human geneticsSNPsMammalian cell culturesBiochemistry

La Jolla, Ca, Us

Study of the interactions of mitochondria with the microtubule cytoskeleton, in S. pombe.Mitochondrial Inheritance and Morphology Laboratory. M.P. YaffeProject creation and management, with a support from the United Mitochondrial Disease Foundation (98,500$) – management of master and PhD students.Characterization of CLASP, a protein binding mitochondria to microtubules.Yeast geneticsCell biologyConfocal microscopy (Spinning disk)Live cell time lapse imagingMolecular biology

Paris, Fr

Doctorat es SciencesStudy of mitochondrial translation in the yeast Schizosaccharomyces pombe.At Centre de Génétique Moléculaire, Gif-sur-Yvette, 91Biogenesis and function of mitochondrial respiratory complexes Laboratory.Characterization of the functional conservation between human and S. pombe factors.Identification of drastic mtDNA depletion in S. pombe during translation blockade.Yeast geneticsMitochondrial genetic and biologyMolecular biology

Research Doctorate, Génétique

Dea, Génétique

Maitrise, Biologie Cellulaire Et Physiologie

Licence, Biologie Générale Et Physiologie

Deug, Sciences De La Vie