- Expertise: Hereditary and acquired nerve and muscle disorders, exercise physiology, electrophysiology, muscle biopsies- Research: Translational muscle physiology combining human studies and AI; focused on treating sarcopenia

- Clinical expertise: Neurology and Neuromuscular disorders, including genetic nerve and muscle disorders, inflammatory nerve and muscle diseases, degenerative conditions, complications from oncology immunotherapy- Principal Investigator Neuromuscular Lab: Conduct physiology research on inflammatory and metabolic muscle diseases through multi-omics analysis and immune phenotyping.- Site PI for multiple clinical trials.- Research collaborations: Immune molecular phenotyping in immune checkpoint inhibitor patients, biomarkers of muscle injury, and endothelial signaling in metabolic disorders- Inpatient and outpatient practice at UT Southwestern, Parkland Hospital, and Institute of Exercise and Environmental Medicine (Texas Health) performing needle muscle biopsies, cardiopulmonary and forearm exercise tests, and EMG/NCS- Education: lectures and hands-on teaching to medical students, residents, and fellows

Clinical Development Lead:• Spearheaded mid- to late-stage clinical development for Taysha’s Giant Axonal Neuropathy (GAN) program, for first-in-human treatment with AAV9 gene therapy for an ultra-rare neurologic condition.• Led clinical development efforts through several critical program junctures, including the cross-functional development ofclinical study documents and the preparation of multiple clinical appendices for various late-stage regulatory packagesubmissions for key FDA interactions.• Responsible for driving essential study design and trial optimization decisions, data-driven endpoint evaluation, selectionand ordering efforts, collaborating closely with both internal regulatory, biostatistics and commercial leaders as well asexternal partners.• Fostered strong working relationships with clinical research sites hosting the study, including partnering to explore anddevelop solutions for the unique clinical research and trial design challenges facing ultra-rare disease drug development.Medical Affairs Consultant:• Led efforts to define genetic testing strategy for trial subject enrollment to successfully achieve study enrollment targets.• Leveraged machine learning to identify patients with rare neurologic disorders, improving study start-up and enrollmentefficiency.• Managed vendor relationships to ensure optimal, strategically aligned service delivery and maintained fit-for-purposepartnerships.• Structured and participated in advisory boards and producing competitive intelligence reports.• Authored, contributed to and reviewed relevant abstracts and manuscripts in alignment with Taysha’s overarching medicalaffairs strategy, ensuring consistency, quality and accuracy in scientific communication.

• Led the analysis of pre-clinical animal data, toxicology and dose information to assess risks and benefits across multipleclinical indications.• Recommended pre-clinical/clinical portfolio growth opportunities by leveraging data-driven solutions to identify potentialneurological indications that may apply to the mechanism of action of the specific small molecule.• Collaborated with leadership to ensure key scientific insights were effectively translated into actionable strategicrecommendations, working cross-functionally to drive innovation and growth aligned with organizational goals.

- Clinical Trial:1. Site co-Investigator: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Zilucoplan in Subjects With Immune-Mediated Necrotizing Myopathy (Ra Pharma)- Trained in neuromuscular medicine and electromyography- Worked with adult and pediatric neuromuscular experts with a focus on inflammatory and congenital myopathies, ALS, genetic neuropathies, myasthenia gravis, and oncology immunomodulatory therapy complications

- Created, piloted, and taught a neurology curriculum for Brigham and Women's Internal Medicine residents including physical exam rounds, morning report, lecture series, online forum, and other conferences- Project completed as part of the Medical Education certificate

- Worked collaboratively with scientific and business leadership to identify and prioritize the nextgeneration of therapeutic targets to pursue with the Relay platform- Integrated interdisciplinary information from literature and databases to help drive business decisions concerning new target selection- Crafted and delivered presentations to business leadership on target summaries and recommendations

- co-Investigator: Prospective Double-Blinded Randomized Field-Based Clinical Trial of Metoclopramide and Ibuprofen for the Treatment of High Altitude Headache and Acute Mountain Sickness

- Investigated cellular/molecular processes involved in and functionality of axolotl brain regeneration- Designed and implemented behavioral assay to study axolotl memory/learning after brain regeneration- Studied genetic signatures that mark neural stem cells along differentiation path in cerebral cortex