Lead technical projects that focus on LIMS, automation, and assay development* Directing cross-disciplinary project with manufacturing, LIMS, QC, and lab teams to standardize reagent validation, which will enable multi-site laboratory scale-out* Leading LIMS integration of a new assay while acting as pioneering technical consumer of the company’s new LIMS platform* Generalized workflow to run any assay from either blood or DNA, fostering international expansion while reducing redraw requests* Led cross-disciplinary project to reorganize lab around automated refrigerator, enabling the business to scale sample throughput by 4x* Led fastest assay development project on Invitae’s platform, integrating and validating the assay in under 2 months, against 10+ months for similar projects* Built automated suite for end-to-end integration testing of assays

I moved to Berlin, Germany for one year and continued working for Bio-Rad remotely for the whole year.

Manage a team of computational biologists. The team's responsibilities include:* Release of a new platform for design and commercialization of assays for digital PCR* Development of new types of digital PCR assays * Analysis of NGS data supporting new product development* Statistal and bioinformatics support for field applications scientists

As ddPCR Content Program Manager, I led the digital PCR assay development at Bio-Rad.I was involved in the assay development program from its inception, starting with the R&D work that enabled us to consistently design high-quality Rare Mutation Detection assays. We quickly scaled up our process, transferred most of the hands-on work to a liquid handling robot, and developed a database to track thousands of assays from design through to validation and then release to customers.During the course of this work, the team developed hundreds of validated mutations detection assays, as well as a robust assay design algorithm with a high success rate on the first pass. We also developed a strong understanding of the thermodynamics driving the phenotypes that we se in digital PCR assay, which continues to inform our assay development.More recently, the Content team built a soon-to-be-released customer facing platform for custom assay design. It will enable Bio-Rad to support custom assay design requests, and to rapidly add support for new types of assays.

* Led R&D efforts for design of digital PCR assays for rare mutation detection. Integrated experimental results and thermodynamic predictions to inform optimal design of assays.* Wrote prototype assay design pipeline (Perl and Python)* Developed and communicated statistical methods in analysis of digital PCR data. Wrote the chapters on Statistics and Error Bars in ddPCR in the Bio-Rad's ddPCR Applications Guide.

Helped biologists make sense of their data * Acted as liaison between biologists, chemists, and software developers during development of a new instrument, helping to design experiments to optimize the overall performance of the system. * Converted a prototype targeted resequencing pipeline (in R) to a release version (in perl), with a 5X increase in speed and the ability to run on either a cluster or a multi-core machine. * Worked with biologists to select best metrics to evaluate and optimize protocols for multiple different types of NGS samples, including MethylSeq, targeted sequencing, and RNASeq

Studied the genome-wide response of cells to glucocorticoids.* Drove the adoption of new technologies in the Yamamoto lab, including ChIP-Seq and self-printed oligonucleotide microarrays.* Served as a central computational advisor to a group of molecular biologists.* Did all the experimental and computational work on a series of ChIP-Seq experiments, including experimental optimization of ChIP-Seq sample prep for a small number of cells and development of a peak-finding algorithm in R.* Developed scripts to extract and analyze genome-wide data relevant to transcriptional regulation.

Assisted biologists with data reduction and analysis. * Identified primary points of failure in image analysis software for interpreting results of linear array assays. Oversaw complete redesign of the software and rescued a failing effort to transition from manual to automated interpretation.* Researched and summarized the statistical basis of current biological research for research scientists.

Developed B2B collaboration application using J2EE technologies. The company folded in October 2001

Started as Software Engineer/Physicist and was promoted to Project Manager (07/1999) and then to Software Department Manager (03/2000) * Revamped software testing and release process.* Revived OEM relationship by delivering major release of critical software on time and developing project plan for future software releases. * Worked in multiple areas of software development including instrument control, analysis of TEM energy loss spectra, and automated image analysis for semiconductor applications.

Developed image analysis software to automate measurement of chromosomes, organelles, and cells.

Designed and developed modular components of a Unix-based back office commercial paper system.