Samine Isaac Email & Phone Number

London, GB

London, England, United Kingdom

• Outsourcing & CRO management (CRO liaison, sourcing, assay set-up & delivery, contract & budget management)
• Project management of in vitro toxicity and safety pharmacology packages for various portfolio projects
• Stakeholder management
• Assay design & assay data management ensuring data quality & FAIR principles
• HitID to Candidate nomination project support (biology, selectivity & toxicity assays)

• Support Project Manager and Chief Operating Officer with technical writing providing bioscience expertise
• Grant proposal writing
• Communication, dissemination and exploitation document writing and planning

• PhD thesis title: “Investigating antigen delivery and presentation of outer membrane vesicle-based cancer vaccines”
• Project managed PhD research encompassing three parallel lines of research
• Designed and performed experiments for in vivo studies, vaccine immunology, immune-oncology, cell assays and microbiology
• Effectively supervised Master’s thesis student
• Coordination and collaboration with colleagues based in Siena
• Proactive contribution of team projects and… Show more PhD thesis title: “Investigating antigen delivery and presentation of outer membrane vesicle-based cancer vaccines”

Cambridge, United Kingdom

• Designated individual (Human Tissue Authority licence manager), quality management for licence compliance and matrix management of team members
• Responsible for delivery of high quality data for cell-based assays in multiple oncology and immuno-oncology projects to inform decision making
• Liaise with CRO for effective and timely coordination of a tumour xenograft murine model proof of concept studies
• Characterise bispecific antibody drug candidates, experience throughout… Show more
• Characterise bispecific antibody drug candidates, experience throughout discovery pipeline to IND (from Yeast display and affinity maturation, to protein production and protein characterisation, and functional assay.
• Training new colleagues – SOPs, instrumentation, in-house assays

Cambridge, United Kingdom

• Characterisation of antibodies via techniques such as westerns, ELISA, ICC and FACS
• Detailed mechanism of action studies for lead Fcabs and mAb2s which includes investigating target binding, cell proliferation, signalling, internalisation and apoptosis
• Design and optimisation of novel assay formats
• Tissue culture of various cell lines and responsible for the organisation of the TC lab
• Protein expression, purification and characterisation (cell culture, protein expression… Show more
• Protein expression, purification and characterisation (cell culture, protein expression in mammalian cell systems, HPLC, affinity and SEC purification, SDS-PAGE, endotoxin testing) Show less

Leiden, Netherlands

Project with FaLCo Biotherapeutics BV involving bacterial display and selection of affinity proteins.

Amsterdam Area, Netherlands

Investigating Nanobodies and their ability to bind chemokine receptors and modulate receptor activity.

London, United Kingdom

Database development. Analysis of pegylation technology and its applicability. Identification of potential market. Reorganisation and filing of IP.

Doctor Of Philosophy (Phd), Cibio, Laboratory Of Synthetic And Stuctural Vaccinology

Master Of Science (Msc), Drug Discovery And Safety, Cum Laude

Bachelor Of Science (Bsc), Biochemistry, 1St Class (Hons)

Activities and Societies: Spanish language exchange, the Culture event, Brighton Festival Chourus. Course included a year studying abroad.