Custom synthesis of Organoborons, Organosilicons, PEG Linkers, Bioactives, Nucleo-sides and Diaryls.Route design and synthesis of complex target moleculesSynthesis of scaffolds, building blocks & lead optimization

Total synthesis of Icumazole A using modified Cadiot-Chodkiewicz couplingTotal synthesis of antibiotic 18-deoxynargenicin A1Advisor: Prof. Mark Rizzacasa

• Design and synthesis of highly efficient deep-blue and blue-emitting complexes (heterocyclic molecules) and their applications in OLEDs.Advisor: Associate Prof. Koushik Venkatesan

• Design and synthesis of boron-based molecules that inhibits Indoleamine-2,3-dioxygenase 1 enzyme. • The main challenge has been to design and synthesize new small molecule inhibitors of IDO1 and perform biophysical and biochemical studies along with enzyme inhibition. • Excellent binding affinity of the boron molecules with IDO1 enzyme as determined by SPR compared to Epacadostat.• Experience in teaching undergraduate students.Advisor: Prof. Louis Rendina

• Synthesis of varieties of aliphatic and aromatic esters(mainly acetates, isobutyrates and acetamide protected esters) from alcohols• Purification, analysis, and characterization of compounds using NMR, GC-MS, and HPLC methods.Supervisor: Associate Prof. Stephen Bell

• Responsible for developing and demonstrating commercially viable multi-step organic synthesis for the manufacture of new molecules • ‘’Hands on‘’ experience of synthetic organic chemistry techniques and design of synthetic pathways• Carrying out synthesis of a wide variety of organic molecules (medicinal chemistry, organic intermediates) from milligram to gram and kilogram scale• Synthesis done using Wittig reaction, demethylation using BBr3, O-alkylation, Grignard reaction, Mitsunobu, Buchwald, Heck,Suzuki, Sonogashira reaction, Mannich, Clarke reaction, N-oxide formation using m-CPBA/ H2O2-Acetic acid method, oxidation reactions using Swern oxidation, MCPBA, Dess-Martin periodinane, PCC, PDC, CAN, reductive aminations, sodium ethoxide & methoxide preparation, different peptide couplings using HATU, HBTU or EDC.HCl/HOBt and Mukaiyama reagent• Preparation of LDA(from n-BuLi/DIPA), reagents using like LiHMDS, n-butyl Lithium, trimethyl aluminium, DIBAL-H, Lthium Aluminium Hydride, DABCO, PPA, Pd/C, Raney Nickel, etc. and drying of solvents like toluene, dichloromethane, hexane, methanol, acetonitrile, ethanol, THF and triethylamine• Purify compounds by different column chromatography purification techniques using manual column, Combiflash, Biotage column, preparative thin layer and High performance liquid chromatography • Hydrogenation reactions using Parr Shaker, Parr autoclave and microwave reactions using CEM microwave• Role of initiating project work, preparing action plan and accurately recording all experimental details in laboratory note book as well as electronically.• Knowledge of GMP laboratory requirements• Contribution to the effective functioning of the research team and develop innovative concepts and ideas for further research• Proper maintenance of safety guidelines, usages and disposal of chemicals

• Synthesize target compounds utilizing both classical and modern technology• Optimize reaction conditions in accord with visual observations to allow rapid, successful scale-up of target compounds• Carrying out synthesis of a wide variety of organic molecules (medicinal chemistry, organic intermediates) from milligram to gram scale• Done reactions under anhydrous and oxygen free conditions, advanced methods used for isolation and purification of organic intermediates• Collaborative and independent handling of the assigned library Medicinal chemistry projects, chemistry exploration, route optimisation and trouble shooting• Knowledge of basic organic chemical reactions, an understanding of chemical nomenclature and ability to perform fundamental chemical calculations• Responsibilities include set-up of reaction apparatus, addition of reagents and solvents, monitoring reactions, work-up, separation, purification and analysis of final compounds• Work on online literature search through SciFinder, Beilstein, Discovery Gate, Patent Search/ Patent Related Database, e-molecule etc. • Being aware of, and keeping up to date with, health and safety issues in all aspects of the work undertaken• Encouraging team spirit and leading to three to four chemists under supervision and support