Samuel Mattern-Schain

Samuel Mattern-Schain Email and Phone Number

Senior Scientist @ Phare Bio
Knoxville, TN, US
Samuel Mattern-Schain's Location
Knoxville, Tennessee, United States, United States
Samuel Mattern-Schain's Contact Details

Samuel Mattern-Schain work email

Samuel Mattern-Schain personal email

About Samuel Mattern-Schain

I am a research scientist with a broad skillset ranging from synthetic chemistry and nanofabrication to tissue culture and cellular biology. During my doctoral studies, I created novel strategies for protein profiling and active targeting/controlled release of medicinal nanotherapies. I was trained in electron microscopy, dynamic light scattering, electrophoresis, mass spectrometry, nuclear magnetic resonance spectroscopy and more. My DARPA-funded postdoctoral work involved the creation of biomimetic smart materials capable of modulating their properties autonomously based on environmental cues. During this time, I gained expertise in material science and electrophysiology, adding cell-free protein synthesis, confocal microscopy, and DNA origami to my set of skills. My research interests in biomimetic strategies for programming smart nanophase materials led me to my current position as a senior research associate within the department of surgery at the UTK Medical Center. Here, I have found success applying what I have learned to create more clinically viable strategies to imbue genetic nanotherapies with cell-specificity and increased efficacies overall. I have also gained expertise in high pressure liquid chromatography, in vitro, ex vivo, and in vivo nanoparticle delivery assays, and quantitative polymerase chain reaction experiments. Importantly, I have garnered a deeper understanding of how lab-based advances in nanotechnology can reach and benefit the public.

Samuel Mattern-Schain's Current Company Details
Phare Bio

Phare Bio

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Senior Scientist
Knoxville, TN, US
Samuel Mattern-Schain Work Experience Details
  • Phare Bio
    Senior Scientist
    Phare Bio
    Knoxville, Tn, Us
  • Orion Therapeutics, Inc.
    Associate Head Of Platform Development
    Orion Therapeutics, Inc. May 2024 - Present
    Boston, Massachusetts, United States
  • Ut Medical Center
    Research Associate
    Ut Medical Center Mar 2020 - May 2024
    Knoxville, Tennessee, United States
  • University Of Tennessee
    Postdoctoral Researcher
    University Of Tennessee Nov 2019 - Mar 2020
    Knoxville Tennessee
    Moved to Friend of the University status so I could continue to collaborate with Prof. Sarles and others before the start my next research position.
  • University Of Tennessee
    Postdoctoral Research Associate
    University Of Tennessee Aug 2018 - Oct 2019
    I worked in the Bioinspired Materials and Transduction lab of Professor Andy Sarles of the Mechanical, Aerospace and Biomedical Engineering department. I applied my chemical expertise to bolster the research efforts of Dr. Sarles and his team while learning invaluable biomolecular engineering skills including electrophysiological and optical characterization of droplet interface bilayers, pendant-drop goniometry, use of optical tweezers and more. Specifically, I applied synthetic biology to smart materials using riboswitch-governed cell free protein synthesis and designed and fabricated DNA origami nanostructures for the study and actuation of lipid membranes.
  • University Of Tennessee
    Graduate Research & Teaching Assistant
    University Of Tennessee Aug 2012 - Dec 2017
    Knoxville, Tennessee Area
    I worked in the lab of Professor Michael Best and also collaborated with Professor Deidra Mountain. I synthesized functional lipids for liposomal investigations of protein-membrane binding interactions, developed novel in-gel liposomal affinity-based protein profiling techniques, formulated liposomal nanocarriers as functional nanodrugs for treating vascular disease and applied natural lipids to actively target and increase nanodrug uptake. Other projects that I participated in included:sSynthesis of a UV-sensitive lipid trigger for promoting release of encapsulated liposomal cargo, design and application of a cation-sensitive lipid trigger for promoting liposomal release, confirmation of content-mixing upon click-induced liposomal fusion of complementary membranes, and co-writing a review of liposomal theranostics.
  • University Of Tennessee
    Research Assistant
    University Of Tennessee Aug 2011 - Aug 2012
    Knoxville, Tn
  • Concord Recreation
    Basketball Coach
    Concord Recreation Dec 2009 - Mar 2010
    Volunteer basketball coach for 7th and 8th grade boys basketball team through the Concord, NH recreation department. We won the championship and the season was a huge success.
  • Westgate English Teaching Corporation
    Cover Instructor And English Instructor At Japenese Universities
    Westgate English Teaching Corporation Apr 2009 - Jul 2009
    Created and edited curriculum and substituted for sick or absent instructors--commuting from western to downtown Tokyo on a daily basis for two months, designed my own lessons and taught them to late teens/early twenties Japanese university students at their universities-- for the last month I replaced a dismissed instructor in Koriyama University in Japan
  • New Hampshire Home Magazine
    Intern/Writer
    New Hampshire Home Magazine Jul 2007 - Jul 2008
    Researched and wrote stories, receiving five bylines {Articles available by request}Reconstructed the magazine's resource sectionWas responsible for the magazine's event CalendarUniversity Park Campus School Mentorship Program Fall 2004; UPCS is a visionary inner-city high school affiliated with Clark UniversityWorked directly with two students from immigrant families for one hour sessions twice weekly, engaging them in after school activities and providing guidance and support as a young adult
  • Zia Grill
    General Manager
    Zia Grill Oct 2006 - Apr 2008
    Worcester, Ma
    Hired and trained employees, assisted with scheduling and other aspects of daily management
  • Northwood Design And Construction
    Builder'S Apprentice
    Northwood Design And Construction Jan 2002 - Jan 2006
    Worked directly with builder, primarily doing finishing work in high-end homes

Samuel Mattern-Schain Skills

Chemical Research Teaching/tutoring Food Service Management Coaching Costumer Service Banking Training/staffing Construction/painting Cooking Writing/editing

Samuel Mattern-Schain Education Details

Frequently Asked Questions about Samuel Mattern-Schain

What company does Samuel Mattern-Schain work for?

Samuel Mattern-Schain works for Phare Bio

What is Samuel Mattern-Schain's role at the current company?

Samuel Mattern-Schain's current role is Senior Scientist.

What is Samuel Mattern-Schain's email address?

Samuel Mattern-Schain's email address is sm****@****utk.edu

What schools did Samuel Mattern-Schain attend?

Samuel Mattern-Schain attended University Of Tennessee-Knoxville, Clark University, Tefl International.

What skills is Samuel Mattern-Schain known for?

Samuel Mattern-Schain has skills like Chemical Research, Teaching/tutoring, Food Service Management, Coaching, Costumer Service, Banking, Training/staffing, Construction/painting, Cooking, Writing/editing.

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