Eikonoklastes Therapeutics is an early stage biopharmaceutical company focused on rapidly advancing innovative medicines for numerous areas of significant unmet clinical need, starting with neurodegenerative diseases. We are iconoclasts who are passionate about finding new and better ways to treat disease.Our first-in-class gene therapy moves beyond single defective gene replacement. It is a transformational, disease-modifying gene supplement therapy with a unique mechanism of action that provides extra copies of a critical gene to cause overexpression of a critical neurotrophic factor that is essential for neuromuscular signaling and function. Our initial focus is on Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig’s Disease), a rare, yet debilitating nerve disease that causes progressive muscle degeneration and eventual death. An estimated 5,000 new patients in the U.S. are diagnosed each year with ALS, and there are few treatment options beyond supportive care. Our dynamic discovery and development approach allows us to focus on accelerated approvals and outsized returns for ALS and potentially other neurodegenerative diseases such as Parkinson’s, Huntington’s, Alzheimer’s, traumatic brain injury, and more.

CincyTech transforms innovation into high performing life science and high tech companies. As a member of the life sciences team, I have helped lead new investments and am active supporting operations in the following portfolio companies:+Airway Therapeutics (Developing rhSP-D for Bronchopulmonary Dysplasia)+Enable Injections (On-Body Delivery Device for Biologics)+XII Medical (Neuromodulation for Obstructive Sleep Apnea)+Genetesis (AI-powered Chest Pain Triage)+Invirsa (Novel Small Molecule to Enhance Innate Immunity)+NDT Bio (Universal Detection System)Alumni+Aerpio Pharmaceuticals (NASDAQ: ARPO)+Akebia Therapeutics (NASDAQ: AKBA)+Assurex Health (PGx Testing; Acquired by Myriad Genetics)+Blue Water Vaccines (Universal Flu Vaccine; NASDAQ: BWV)+Myonexus Therapeutics (Pioneering Gene Therapy; Acquired by Sarepta)+Standard Bariatrics (Medical Device Platform for Bariatric Surgery; Acquired by Teleflex)

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Vincere's small molecules increase mitophagy and have potential to be the first ever medicines to slow or stop Parkinson's disease and other age-related diseases.

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Building solar for the next generation.

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Mining the microbiome for biomarkers and novel therapeutic molecules.

Invirsa’s lead compound (INV-102) quickly and predictably augments the body’s response to DNA damage, greatly improving cell stability for the treatment of numerous diseases of the eye.

Better RNA expression for better focused solutions. (Acquired by Ginkgo Bioworks)

Developing transformational vaccines from University of Oxford, St. Jude Children's Hospital, and Cincinnati Children's Hospital Medical Center. (NASDAQ: BWV)

The Standard Sleeve is an anatomy-based approach to sleeve gastrectomy. It enables surgeons to perform gastric sleeves faster and easier and to achieve optimal sleeve anatomy. (Acquired by Teleflex)

High Resolution Virtual AI Software for Imaging Radar. (Acquired by Ambarella)

Your instant shortcut to a better day's work. (Acquired by Dropbox)

Developing a neuromodulation medical device for the treatment of obstructive sleep apnea.

Pioneering gene therapy for Limb Girdle Muscular Dystrophy. (Acquired by Sarepta Therapeutics)

+ Led a team of 4 researchers to analyze dexmedetomidine as a safer anesthetic for pediatric surgery+ Analyzed data with SQL queries and with Stata for deeper understanding of the relationship between biological age, neuronal age and drug toxicity to evaluate anesthetic effects on pediatric brain tissue

+ Advisory committee contributing to strategic guidance for product advice, beta testing and business development initiatives

+ Analyzed market research data to identify targets in the AD drug market and to inform future clinical trial design+ Developed database of AD clinical trials conducted globally in order to help define favorablecountries to conduct subsequent clinical trials

+ Studied the effect modification by age on stroke rates in patients with carotid stenosis treated with either carotid artery stenting versus carotid endarterectomy

+ Analyzed the true cost-effectiveness of pediatric vaccination with the Rotavirus vaccine+ Evaluated the relationship between adults and children as a significant mechanism of transmission to determine the impact of pediatric vaccination on the burden of rotavirus in adults

+ Analyzed sediment samples from alpine lakes in Beartooth Mountains of Montana to better understand global climate changes+ Developed techniques critical for precise lab work involving zooplankton and dissolved organic matter

+ Prototype testing of continuous physiologic monitoring systems to optimize human effectiveness+ Analyzed data with MATLAB to integrate results from biological and cognitive monitoring technologies+ Developed novel circuitry platforms to support cutting-edge solar and wind power technologies