Scientist• Played a key role in the characterisation, pre-clinical research and Candidate Selection into lead drug candidate efficacy in both cell and primary line based assays, as well as within primary tumours. • Procurement of primary tissues with resource management of tissue between projects. • Report writing for patents and pre-IND documents. • Extensive flow immuno and phenotypic assay design, development and deliverance to SOP standard.• Working within a matrix project lead environment in a fast paced company to deliver Candidate Selection criteria. • Development and execution of plate and (primary) cell based screening activities to identify lead clones for candidate selection.• Competent in training of new laboratory staff and technology transfer to other sites and external companies.• Comfortable using electronic laboratory notebook systems for day to day recording of data. Laboratory manager:• Chair of the Adaptate Health & Safety incorporating GM committee, scheduling meetings and filing minutes from quarterly sessions.• Responsible for the maintenance of company health & safety documents and procedures, creating/advising on new documentation where necessary.• Implemented health & safety training, ensuring that colleagues are competent and safe in their areas of work. • Took lead in annual safety audits conducted by an external health & safety advisor.

Process Development Scientist:• Played a key role in the development and implementation of strategy in bioprocess development, with focus of adapting process to enable scale-up suitable for clinical manufacture.• Planned and executed small-scale optimization studies to improve research grade process, creating a more GMP compliant process.• Played an active role in the evaluation and selection of manufacturing equipment needed for the clinical production of cell-based products, including authoring and reviewing process protocols.• Provided manufacturing input for regulatory filings, particularly around raw materials.• Assisted in the tech transfer of a key company product to clinical manufacturing organisation. • Generated and submitted key data to allow for the filing of two company patents. • Responsible for maintaining primary cell cultures derived from human tissues. • Regularly performed analytical assays aimed at assessing cell phenotype and activity, including but not limited to; Flow-cytometry and Luminex.Company Safety officer:• Chair of the GammaDelta Therapeutics GM safety committee, scheduling and filing minutes from quarterly meetings.• Working alongside laboratory manager responsible for the maintenance of company health & safety documents and procedures. Creating/advising on new documentation where necessary.• Working alongside laboratory manager implemented health & safety training, ensuring that colleagues are competent and safe in their areas of work. • Took part in annual audits conducted by an external health & safety advisor.In addition to above roles: Maintenance of company quality systems.

Associate Scientist role:• Responsible for maintaining primary cell cultures derived from human tissues. • Creation of frozen cell stocks, cell pellets and supernatant stocks for later analysis in functional and analytical assays, together with tracking and archiving vial numbers.• Regularly performed analytical assays aimed at assessing cell phenotype and activity, including but not limited to; Flow-cytometry and Luminex.• Ensured that all data generated was well recorded and presented in a way which was suitable for uploading to electronic laboratory notebook system. • Interim laboratory manager (Feb17-Oct17):o Responsible for maintaining laboratory consumable stocks and implementing ordering when necessary to support the research efforts of the team. Generated and maintained the company inventory.o Actively took part in commissioning of laboratory areas, which included equipment and reagent acquisition as well as equipment initialisation. Initiated and managed service contracts for laboratory equipment. o Played a key role in developing and maintaining company quality systems, in order to comply with HTA standards. This includes playing an active role in implementing quality systems which allowed GammaDelta Therapeutics to obtain HTA storage license. Safety officer role• Chair of the GammaDelta Therapeutics GM safety committee, scheduling and filing minutes from quarterly meetings.• Wholly responsible for the creation and implementation of company health & safety documents and procedures, building the framework de novo. Documentation includes but is not limited to; company policies, risk assessments and COSHH assessments.• Designed and implemented staff training and development in terms of health and safety, ensuring that colleagues are competent and safe in their areas of work. • Working alongside company health & safety advisor to obtain a company GM license. • Took part in annual audits conducted by an external health & safety advisor.

In addition to research scientist role; Laboratory management and safety officer. Research scientist role• Regularly performing assays to support the Kesios pre-clinical drug discovery cascade. Assays performed include ELISA, western blotting and qRT-PCR. • Cell line analysis to confirm the expression of target proteins and interactions by immunoprecipitation and protein arrays using cell and tumour lysates. • Responsible for maintaining cultures of adherent and non-adherent cell lines, including cancer cell lines. • Creation of cell banks and cell pellets for later analysis in functional and biochemical assays, together with tracking and archiving vial numbers.• Solely responsible for ensuring laboratory consumables are adequate and implementing ordering when necessary to support the research efforts of the team. Generated and maintained the company inventory.• Played an active role in the commissioning of laboratory areas, which included equipment and reagent acquisition as well as equipment initialisation. Single-handedly initiated and managed service contracts for laboratory equipment. Safety officer role• Chair of the Kesios health & safety committee, scheduling and filing minutes from monthly meetings.• Wholly responsible for the creation and implementation of all company health & safety documents and procedures, building the framework de novo. Documentation includes but is not limited to; company policies, risk assessments and COSHH assessments.• Designed and implemented staff training and development in terms of health and safety, ensuring that colleagues are competent and safe in their areas of work. • Working alongside responsible persons at other institutions to obtain a company GMO license. • Prepared for and co-ordinated annual audits conducted by an external health & safety advisor.

• Production of biological products such as antigens through mammalian cell culturing techniques, using both batch and fed-batch systems. Batch scale ups start at 1.8ml, and can reach in excess of 100 litres.• Carrying out regular aseptic work through the use of microbiological safety cabinets (ISO class 5 environment), as well as through the use of sterile connections. Ensuring strict adherence to production paperwork, including the timely completion of records in order to enable a smooth manufacturing flow.• Sampling of cultures for metabolites (glucose & lactate) in addition to determining culture pH.• The use and maintenance of liquid nitrogen storage systems and cell banks.• Management of stock levels through the use of electronic stock maintenance systems.• Working hard with the rest of the team to adhere to a set manufacturing schedule and elevating any problems to line management.• Involved in internal audits and contributing to the site achieving the best compliance record within the division in 2015 by working towards an audit-ever ready state. • Taking responsibility for the tidiness and cleanliness of an area of the laboratory and providing suggestions for improvement.• Compliance to Abbott quality systems, as well as keeping up to date with training records.

• Updating of company COSHH reports, with the use of current MSDS reports provided both by the company and through self sourcing. • Creation of COSHH processes in which hazards for various steps of manufacturing processes are noted in order of use.• Applying hazard categories and assessing the risks of all chemicals held on site using the Globally Harmonised System of classification (GHS).• Creation of an assessment index spreadsheet containing details of which chemicals and buffers are used, frequency of use, risk posed by each chemical/buffer, which technicians are using them and finally the locations they are used in. • Interacting with a variety of different departments in order to meet tight deadlines for the completion of the risk assessment project.• Ensured organisation of accumulated files and folders, allowing ease of access for other EHS staff.

• Updating and creation of COSHH reports using the global harmonised system (GHS) for all buffers and processes used on site. • Updating and sourcing copies of material safety data sheets (MSDS) for all chemicals used on site.• Creation of an assessment index spreadsheet containing details of which chemicals and buffers are used, frequency of use, risk posed by each chemical/buffer, which technicians are using them and finally the locations they are used in. • Ensured organisation of accumulated files and folders, allowing ease of access for other Abbott staff.