ALX-009 is a first-in class orphan drug candidate targeting lung infections in Cystic Fibrosis (CF) patients. Our innovation is to combine two endogenous molecules - OSCN- and lactoferrin - in a "ready-to-inhale" solution.My current challenge: coordinate development of an innovative home-use medical device to enable extemporaneous production of ALX-009.

ALX-009 is an innovative combination of two endogenous molecules - OSCN- and lactoferrin - exhibiting antimicrobial properties compensating the defective innate immune system in Cystic Fibrosis (CF) patients.ALX-009 is a first-in class orphan drug candidate, presented as a solution for inhalation to treat lung infections in CF patients.Find out our posters and talks :http://www.alaxia-pharma.eu/poster-and-talk/ “Therapeutic potential of inhaled ALX-009 (OSCN-/bLF) for emergent and multiresistant bacterial infections in Cystic Fibrosis” (2015)Y. Sonmez, C. Bechetoille, S. Perrotto and V. Juarez-Perez - NACFC Phoenix, Arizona, 29th annual congress. “Successful Burkholderia spp. eradication with hypothiocyanite/lactoferrin. In vitro study evidence over a worldwide collection of clinical strains” (2015)Y. Sonmez, C. Bechetoille, S. Perrotto, A. Payet-Burin and V. Juarez-Perez - ECFS Brussels, Belgium, 38th annual congress.“Burkholderia spp. resistances strategies. OSCN-/bLF (ALX-009), Is its mode of action a bulwark against bacterial resistance?” (2015)V. Juarez-Perez, C. Bechetoille, Y. Somnez and S. Perrotto - IBCWP Vancouver, Canada. 19th annual congress.“Bactericidal potential of OSCN-, bovine lactoferrin and their combination on clinical isolates of Burkholderia spp.” (2014)Y. Sonmez, C. Bechetoille, S. Perrotto, A. Payet-Burin, V. Juarez-Perez - NACFC Atlanta, Georgia, 28th annual congress.“Feasibility study of OSCN- and lactoferrin (Meveol®) nebulization for Cystic Fibrosis patients” (2011)S. Perrotto, S. Le Guellec, L. Vecellio, E. Fichant, P. Stordeur, P. Bordeau, J.P Perraudin - ECFS Hamburg, Germany, 34th annual congress.

Responsibilities: - Operate and manage all aspects of the school, including teachers and students recruitment, planning, marketing and communication - Actively develop and maintain positive staff and students relationships - Organize and conduct staff meetings, workshops - Coordinate resources to ensure successful programs implementation.http://www.coursdiderot.com/

“Soil metatranscriptomics for mining eukaryotic heavy metal resistance genes” (2013)Lehembre F, Doillon D, David E, Perrotto S, et al. - Environ Microbiol. 2013 Oct;15(10):2829-40.“A quorum-quenching approach to identify quorum-sensing-regulated functions in Azospirillum lipoferum” (2008)Boyer M, Bally R, Perrotto S, Chaintreuil C, Wisniewski-Dyé - F.Res Microbiol. 2008 Nov-Dec;159(9-10):699-708.